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HSP90AB1 and DDX24
Number of citations of the paper that reports this interaction (PubMedID
40437099
)
172
Data Source:
BioGRID
(cross-linking study)
HPRD
(two hybrid)
HSP90AB1
DDX24
Description
heat shock protein 90 alpha family class B member 1
DEAD-box helicase 24
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
COP9 Signalosome
Cell Surface
Membrane
Protein-containing Complex
Aryl Hydrocarbon Receptor Complex
Secretory Granule Lumen
Melanosome
Neuronal Cell Body
Dendritic Growth Cone
Axonal Growth Cone
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Protein Folding Chaperone Complex
Dynein Axonemal Particle
Ficolin-1-rich Granule Lumen
HSP90-CDC37 Chaperone Complex
Nucleus
Nucleolus
Cytoplasm
Membrane
Molecular Function
Nucleotide Binding
RNA Binding
Double-stranded RNA Binding
Protein Binding
ATP Binding
ATP Hydrolysis Activity
Protein Kinase Regulator Activity
Kinase Binding
Protein Kinase Binding
MHC Class II Protein Complex Binding
Nitric-oxide Synthase Regulator Activity
TPR Domain Binding
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Peptide Binding
Identical Protein Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
ATP-dependent Protein Binding
Protein Folding Chaperone
Cadherin Binding
Protein Dimerization Activity
Tau Protein Binding
Unfolded Protein Binding
DNA Polymerase Binding
Protein Phosphatase Activator Activity
Disordered Domain Specific Binding
ATP-dependent Protein Folding Chaperone
Receptor Ligand Inhibitor Activity
Histone Methyltransferase Binding
Nucleotide Binding
Nucleic Acid Binding
RNA Binding
RNA Helicase Activity
Helicase Activity
Protein Binding
ATP Binding
Hydrolase Activity
ATP Hydrolysis Activity
Biological Process
Placenta Development
Protein Folding
Response To Unfolded Protein
Telomere Maintenance Via Telomerase
Virion Attachment To Host Cell
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Protein Ubiquitination
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Localization
Cellular Response To Heat
Negative Regulation Of Apoptotic Process
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Cell Differentiation
Protein Stabilization
Chaperone-mediated Protein Complex Assembly
Regulation Of Cell Cycle
Cellular Response To Interleukin-4
Supramolecular Fiber Organization
Negative Regulation Of Proteasomal Protein Catabolic Process
Telomerase Holoenzyme Complex Assembly
Positive Regulation Of Protein Localization To Cell Surface
RNA Metabolic Process
Pathways
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Regulation of actin dynamics for phagocytic cup formation
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
HSF1 activation
Attenuation phase
HSF1-dependent transactivation
Sema3A PAK dependent Axon repulsion
Uptake and function of diphtheria toxin
Neutrophil degranulation
The NLRP3 inflammasome
The role of GTSE1 in G2/M progression after G2 checkpoint
Aryl hydrocarbon receptor signalling
ESR-mediated signaling
RHOBTB2 GTPase cycle
Estrogen-dependent gene expression
Chaperone Mediated Autophagy
Purinergic signaling in leishmaniasis infection
Potential therapeutics for SARS
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Assembly and release of respiratory syncytial virus (RSV) virions
Respiratory syncytial virus genome replication
Drugs
Geldanamycin
9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine
Radicicol
Tanespimycin
SNX-5422
CCT-018159
8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE
4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOL
(5E)-14-CHLORO-15,17-DIHYDROXY-4,7,8,9,10,11-HEXAHYDRO-2-BENZOXACYCLOPENTADECINE-1,12(3H,13H)-DIONE
(5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE
(5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE
(5Z)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE
METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE
2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE
Polaprezinc
Diseases
GWAS
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Red blood cell count (
32888494
)
Reticulocyte count (
32888494
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder (
26184070
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Interacting Genes
68 interacting genes:
ACD
AKT1
ANXA1
ARHGAP1
BTG3
CCT2
CDC37L1
CDK4
CDKN2A
CHORDC1
CHUK
CLIC4
CSNK2A1
CYP17A1
DDX24
EGFR
ENO1
ERBB2
ESR1
ESRRB
FCHSD2
GSK3A
GSK3B
HSPB1
IKBKB
IKBKE
IKBKG
ITGB1BP2
KEAP1
MAP3K14
MAP3K3
MAPK6
MKNK1
MYCBP2
NR2C2
NR3C1
NR4A1
OGT
PGR
POT1
PPID
PTP4A2
RAF1
RHOBTB2
SERPINB5
SGTA
SHKBP1
SIRPA
SLC34A1
STARD13
STAT1
STAT3
SUMO2
TAF1D
TBK1
TERF1
TINF2
TNNT1
TP53
TSSK6
UBE2D3
UBE3A
UNC45A
USP50
WASL
WEE2-AS1
XIAP
YWHAB
37 interacting genes:
BCS1L
BRCA1
CSNK2A1
EIF3E
EP300
FADD
FILNC1
GIT1
GLRA2
HSP90AB1
HSPA5
IDO1
ITGB3BP
LMNA
MDM2
MKS1
MRPL4
NRXN2
PAFAH1B3
PIN1
POLA2
PRF1
PTEN
PTPN23
RAE1
RNF10
SPACA9
SPTAN1
TERF1
TERF2
TERF2IP
TMEM9B
TPI1
TRDMT1
UBE2I
USP7
VDAC3
Entrez ID
3326
57062
HPRD ID
06763
05860
Ensembl ID
ENSG00000096384
ENSG00000089737
Uniprot IDs
B4DGL0
P08238
Q6PK50
Q9GZR7
PDB IDs
1QZ2
1UYM
2L6J
3FWV
3NMQ
3PRY
3UQ3
5FWK
5FWL
5FWM
5FWP
5UC4
5UCH
5UCI
5UCJ
6N8W
6N8Y
7ULJ
7Z37
7Z38
7ZR0
7ZR5
7ZR6
7ZUB
8EOA
8EOB
8GAE
8GFT
8QMO
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Macromolecule Metabolic Process
Intracellular Signal Transduction
Positive Regulation Of Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Kinase Activity
Intracellular Signaling Cassette
Cytosol
Positive Regulation Of Macromolecule Biosynthetic Process
Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Metabolic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Intracellular Receptor Signaling Pathway
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Biosynthetic Process
Regulation Of Intracellular Signal Transduction
Identical Protein Binding
Kinase Activity
Nuclear Receptor Activity
Negative Regulation Of Macromolecule Metabolic Process
Shelterin Complex
Protein Serine Kinase Activity
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Proteolysis
Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Signal Transduction
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Telomere Maintenance Via Telomerase
Nuclear Telomere Cap Complex
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
IkappaB Kinase Activity
Nucleus
Estrogen Response Element Binding
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Catabolic Process
Regulation Of Telomere Maintenance Via Telomere Lengthening
Regulation Of Protein Metabolic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
RNA-templated DNA Biosynthetic Process
Shelterin Complex
Cellular Component Assembly
Nuclear Body
Regulation Of Protein Stability
Nuclear Telomere Cap Complex
G-rich Strand Telomeric DNA Binding
Negative Regulation Of Cellular Component Organization
Telomere Capping
Regulation Of Cellular Component Organization
PML Body
Regulation Of Telomere Maintenance
Negative Regulation Of Telomeric D-loop Disassembly
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Negative Regulation Of DNA Recombination At Telomere
Organelle Organization
Protein Localization To Organelle
Negative Regulation Of Macromolecule Metabolic Process
Protein Stabilization
Symbiont-mediated Disruption Of Host Cell PML Body
Negative Regulation Of Catabolic Process
Telomere Maintenance Via Telomerase
P53 Binding
Regulation Of Cell Cycle Process
Negative Regulation Of Metabolic Process
Regulation Of Cell Communication
Protein-containing Complex
Regulation Of Signaling
Regulation Of Organelle Organization
Telomeric DNA Binding
Negative Regulation Of Protein Metabolic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Telomere Maintenance Via Telomere Lengthening
DNA Biosynthetic Process
Nucleoplasm
Regulation Of Cell Cycle
Telomere Maintenance
Receptor Serine/threonine Kinase Binding
Regulation Of Establishment Of Protein Localization To Telomere
Negative Regulation Of Apoptotic Process
Negative Regulation Of Telomere Maintenance
Regulation Of DNA Metabolic Process
Establishment Of Protein Localization To Organelle
Positive Regulation Of Metabolic Process
Negative Regulation Of Programmed Cell Death
Protein Localization To Chromosome
Regulation Of Establishment Of Protein Localization To Chromosome
Telomerase Activity
Protection From Non-homologous End Joining At Telomere
Negative Regulation Of Small Molecule Metabolic Process
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