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HSP90AB1 and IKBKB
Number of citations of the paper that reports this interaction (PubMedID
14743216
)
0
Data Source:
HPRD
(in vitro)
HSP90AB1
IKBKB
Description
heat shock protein 90 alpha family class B member 1
inhibitor of nuclear factor kappa B kinase subunit beta
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
COP9 Signalosome
Cell Surface
Membrane
Protein-containing Complex
Aryl Hydrocarbon Receptor Complex
Secretory Granule Lumen
Melanosome
Neuronal Cell Body
Dendritic Growth Cone
Axonal Growth Cone
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Protein Folding Chaperone Complex
Dynein Axonemal Particle
Ficolin-1-rich Granule Lumen
HSP90-CDC37 Chaperone Complex
Nucleus
Cytoplasm
Cytosol
IkappaB Kinase Complex
Cytoplasmic Side Of Plasma Membrane
Membrane
CD40 Receptor Complex
Membrane Raft
Molecular Function
Nucleotide Binding
RNA Binding
Double-stranded RNA Binding
Protein Binding
ATP Binding
ATP Hydrolysis Activity
Protein Kinase Regulator Activity
Kinase Binding
Protein Kinase Binding
MHC Class II Protein Complex Binding
Nitric-oxide Synthase Regulator Activity
TPR Domain Binding
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Peptide Binding
Identical Protein Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
ATP-dependent Protein Binding
Protein Folding Chaperone
Cadherin Binding
Protein Dimerization Activity
Tau Protein Binding
Unfolded Protein Binding
DNA Polymerase Binding
Protein Phosphatase Activator Activity
Disordered Domain Specific Binding
ATP-dependent Protein Folding Chaperone
Receptor Ligand Inhibitor Activity
Histone Methyltransferase Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
IkappaB Kinase Activity
Kinase Activity
Transferase Activity
Protein Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Scaffold Protein Binding
Protein Serine Kinase Activity
Transferrin Receptor Binding
Biological Process
Placenta Development
Protein Folding
Response To Unfolded Protein
Telomere Maintenance Via Telomerase
Virion Attachment To Host Cell
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Protein Ubiquitination
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Localization
Cellular Response To Heat
Negative Regulation Of Apoptotic Process
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Cell Differentiation
Protein Stabilization
Chaperone-mediated Protein Complex Assembly
Regulation Of Cell Cycle
Cellular Response To Interleukin-4
Supramolecular Fiber Organization
Negative Regulation Of Proteasomal Protein Catabolic Process
Telomerase Holoenzyme Complex Assembly
Positive Regulation Of Protein Localization To Cell Surface
Protein Polyubiquitination
Pattern Recognition Receptor Signaling Pathway
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Inflammatory Response
Canonical NF-kappaB Signal Transduction
Response To Virus
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Peptidyl-serine Phosphorylation
Signal Transduction Involved In Regulation Of Gene Expression
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Protein Maturation
Interleukin-1-mediated Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Protein Localization To Plasma Membrane
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Regulation Of Establishment Of Endothelial Barrier
Negative Regulation Of Bicellular Tight Junction Assembly
Pathways
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Regulation of actin dynamics for phagocytic cup formation
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
HSF1 activation
Attenuation phase
HSF1-dependent transactivation
Sema3A PAK dependent Axon repulsion
Uptake and function of diphtheria toxin
Neutrophil degranulation
The NLRP3 inflammasome
The role of GTSE1 in G2/M progression after G2 checkpoint
Aryl hydrocarbon receptor signalling
ESR-mediated signaling
RHOBTB2 GTPase cycle
Estrogen-dependent gene expression
Chaperone Mediated Autophagy
Purinergic signaling in leishmaniasis infection
Potential therapeutics for SARS
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Assembly and release of respiratory syncytial virus (RSV) virions
Respiratory syncytial virus genome replication
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Regulation of NF-kappa B signaling
PKR-mediated signaling
SLC15A4:TASL-dependent IRF5 activation
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Modulation of host responses by IFN-stimulated genes
Drugs
Geldanamycin
9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine
Radicicol
Tanespimycin
SNX-5422
CCT-018159
8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE
4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOL
(5E)-14-CHLORO-15,17-DIHYDROXY-4,7,8,9,10,11-HEXAHYDRO-2-BENZOXACYCLOPENTADECINE-1,12(3H,13H)-DIONE
(5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE
(5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE
(5Z)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE
METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE
2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE
Polaprezinc
Mesalazine
Acetylsalicylic acid
Auranofin
Arsenic trioxide
MLN0415
Acetylcysteine
Ertiprotafib
Fostamatinib
Diseases
GWAS
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Red blood cell count (
32888494
)
Reticulocyte count (
32888494
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
68 interacting genes:
ACD
AKT1
ANXA1
ARHGAP1
BTG3
CCT2
CDC37L1
CDK4
CDKN2A
CHORDC1
CHUK
CLIC4
CSNK2A1
CYP17A1
DDX24
EGFR
ENO1
ERBB2
ESR1
ESRRB
FCHSD2
GSK3A
GSK3B
HSPB1
IKBKB
IKBKE
IKBKG
ITGB1BP2
KEAP1
MAP3K14
MAP3K3
MAPK6
MKNK1
MYCBP2
NR2C2
NR3C1
NR4A1
OGT
PGR
POT1
PPID
PTP4A2
RAF1
RHOBTB2
SERPINB5
SGTA
SHKBP1
SIRPA
SLC34A1
STARD13
STAT1
STAT3
SUMO2
TAF1D
TBK1
TERF1
TINF2
TNNT1
TP53
TSSK6
UBE2D3
UBE3A
UNC45A
USP50
WASL
WEE2-AS1
XIAP
YWHAB
91 interacting genes:
ACVR1
AKT1
AURKA
BTRC
CASP8
CCAR2
CDC37
CFLAR
CHUK
COPS3
COPS4
COPS5
CSF2RA
CSF2RB
CTNNB1
CUEDC2
E2F4
EIF2AK2
EIF2AK3
ELP1
FAF1
FANCA
FOXO3
GLI1
HMGCL
HSP90AA1
HSP90AB1
HTT
IKBKG
IRS1
JUN
KLHL21
MAP3K1
MAP3K11
MAP3K13
MAP3K14
MAP3K3
MAP3K7
MAVS
MTDH
MYC
NAA20
NCOA3
NEDD4L
NFKB1
NFKB2
NFKBIA
NFKBIB
NR2C2
PEBP1
PELI1
PLK1
PPARG
PPM1B
PPP2R3C
PRKCA
PRKCB
PRKCD
PRKCE
PRKCQ
PRKCZ
PRKDC
RELA
RICTOR
ROCK1
SAMHD1
SASH1
SQSTM1
SRC
STAP2
TAB2
TANK
TBK1
TFAP2C
TGFBR1
TNFAIP3
TNFRSF1A
TP53
TP73
TRAF1
TRAF2
TRAF3IP2
TRIM21
TRIM27
TRPC4AP
TSC1
TWIST1
UBB
UBC
VHL
YWHAB
Entrez ID
3326
3551
HPRD ID
06763
04462
Ensembl ID
ENSG00000096384
ENSG00000104365
Uniprot IDs
B4DGL0
P08238
Q6PK50
A0A499FJS7
G3V105
O14920
PDB IDs
1QZ2
1UYM
2L6J
3FWV
3NMQ
3PRY
3UQ3
5FWK
5FWL
5FWM
5FWP
5UC4
5UCH
5UCI
5UCJ
6N8W
6N8Y
7ULJ
7Z37
7Z38
7ZR0
7ZR5
7ZR6
7ZUB
8EOA
8EOB
8GAE
8GFT
8QMO
3BRT
3BRV
4E3C
4KIK
8OMV
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Macromolecule Metabolic Process
Intracellular Signal Transduction
Positive Regulation Of Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Kinase Activity
Intracellular Signaling Cassette
Cytosol
Positive Regulation Of Macromolecule Biosynthetic Process
Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Metabolic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Intracellular Receptor Signaling Pathway
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Biosynthetic Process
Regulation Of Intracellular Signal Transduction
Identical Protein Binding
Kinase Activity
Nuclear Receptor Activity
Negative Regulation Of Macromolecule Metabolic Process
Shelterin Complex
Protein Serine Kinase Activity
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Proteolysis
Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Signal Transduction
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Telomere Maintenance Via Telomerase
Nuclear Telomere Cap Complex
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
IkappaB Kinase Activity
Nucleus
Estrogen Response Element Binding
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Catabolic Process
Regulation Of Telomere Maintenance Via Telomere Lengthening
Regulation Of Protein Metabolic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Intracellular Signal Transduction
Cytosol
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Regulation Of Metabolic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Apoptotic Process
Regulation Of Protein Metabolic Process
Signal Transduction
Protein Modification Process
Cytoplasm
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Non-canonical NF-kappaB Signal Transduction
Protein Serine/threonine Kinase Activity
Response To Stress
Intracellular Signaling Cassette
Macromolecule Metabolic Process
Protein Kinase Activity
Ubiquitin Protein Ligase Binding
Enzyme Binding
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Protein Modification Process
Protein Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Post-translational Protein Modification
Regulation Of Immune Response
Regulation Of Gene Expression
Positive Regulation Of Catabolic Process
Regulation Of Apoptotic Signaling Pathway
Regulation Of Immune System Process
Cell Surface Receptor Signaling Pathway
Protein Serine Kinase Activity
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