HSP90AB1 and MAPK6

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		HSP90AB1	MAPK6
Gene Name		heat shock protein 90kDa alpha (cytosolic), class B member 1	mitogen-activated protein kinase 6
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol COP9 Signalosome Cell Surface Membrane Inclusion Body Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane Melanosome Extracellular Vesicular Exosome	Nucleus Cytoplasm
	Molecular Function	UTP Binding CTP Binding Double-stranded RNA Binding Protein Binding ATP Binding GTP Binding Sulfonylurea Receptor Binding Kinase Binding Protein Kinase Binding MHC Class II Protein Complex Binding Nitric-oxide Synthase Regulator Activity TPR Domain Binding DATP Binding Ion Channel Binding Poly(A) RNA Binding Unfolded Protein Binding	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Heterodimerization Activity
	Biological Process	Placenta Development Protein Folding Response To Unfolded Protein Axon Guidance Response To Salt Stress Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Heat Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Size Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Interleukin-4 Cellular Response To Organic Cyclic Compound Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cellular Response To Heat	MAPK Cascade Protein Phosphorylation Cell Cycle Signal Transduction
Pathways		HSF1 activation Axon guidance Semaphorin interactions Inflammasomes Attenuation phase Cellular response to heat stress HSF1-dependent transactivation Uptake and actions of bacterial toxins The NLRP3 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Sema3A PAK dependent Axon repulsion Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Uptake and function of diphtheria toxin Innate Immune System
Drugs		Geldanamycin 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine Adenosine-5\'-Diphosphate Radicicol 4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE 4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOL (5E)-14-CHLORO-15,17-DIHYDROXY-4,7,8,9,10,11-HEXAHYDRO-2-BENZOXACYCLOPENTADECINE-1,12(3H,13H)-DIONE (5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE (5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE (5Z)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE
Diseases
GWAS
Protein-Protein Interactions		41 interactors: ACD AKT1 ARHGAP1 CCT2 CDC37L1 CDKN2A CHORDC1 CHUK CLIC4 CSNK2A1 CYP17A1 DDX24 ESR1 FCHSD2 HIF1A IKBKB IKBKE IKBKG MAP3K14 MAP3K3 MAPK6 MKNK1 NR2C2 NR4A1 POT1 PPID SGTA SLC34A1 STARD13 STAT1 STAT3 TAF1D TBK1 TERF1 TINF2 TNNT1 TP53 TSSK6 USP50 WASL YWHAB	167 interactors: ACTG1 ACTR1B AMPH ANAPC5 ANK3 APBA2 APOA1 APOA1BP ARHGDIA ARPC3 ATG9A ATP5J BAG6 BARX1 BBS10 C21orf59 CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFL1 CNTN1 CNTRL COPS6 CSE1L CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DSCR3 DST EDF1 EEF1A2 EGLN3 EIF1 EIF3C EIF4A1 ELOF1 EMD FAM49B FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GNB2L1 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NDUFS6 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLK1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 PVRL2 RAB2A RAB31 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPT3 SEPT5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 WDR26 WDR34 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775
Entrez ID		3326	5597
HPRD ID		06763	04213
Ensembl ID		ENSG00000096384	ENSG00000069956
Uniprot IDs		B4DGL0 P08238 Q6PK50	Q16659
PDB IDs		1QZ2 1UYM 3NMQ 3PRY	2I6L
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of I-kappaB Kinase/NF-kappaB Signaling Intracellular Signal Transduction Positive Regulation Of Metabolic Process I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Telomere Maintenance Positive Regulation Of Cellular Biosynthetic Process Regulation Of Telomere Maintenance Via Telomerase Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Catalytic Activity Negative Regulation Of DNA Replication Regulation Of Metabolic Process Regulation Of Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Telomere Maintenance Cellular Response To Stimulus Apoptotic Process Telomere Assembly Programmed Cell Death Immune Response-regulating Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cell Death Death Regulation Of Cell Death Regulation Of Immune System Process MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Signaling Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Transcription, DNA-templated Phosphorylation Homeostatic Process Regulation Of Organelle Organization Toll-like Receptor 4 Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Hormone Stimulus Regulation Of Apoptotic Process Negative Regulation Of Chromosome Organization Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of DNA Metabolic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Metabolic Process Innate Immune Response Positive Regulation Of Gene Expression Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter	Cell Cycle Cellular Process Organelle Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Mitotic Cell Cycle Cellular Metabolic Process Cell Cycle Process Gene Expression Regulation Of Metabolic Process Regulation Of Catalytic Activity Response To Organic Substance Cellular Component Assembly Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Process Cellular Response To Organic Substance Regulation Of Gene Expression Regulation Of Cellular Component Organization Regulation Of Apoptotic Process Positive Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Immune Response Regulation Of Immune System Process Cellular Macromolecule Biosynthetic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Biosynthetic Process Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Response To Wounding Negative Regulation Of Signal Transduction RNA Metabolic Process Regulation Of Cell Death Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Membrane Organization Positive Regulation Of Phosphorylation Heterocycle Metabolic Process Cell Division RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated
Tagcloud ?		1as atg aurothioglucose bpd bronchopulmonary bso buthionine comparatively cysteines cytoprotection h1299 hyperoxia hyperoxic nitrosylation oxidoreductase peroxiredoxin pharmacologically redox relies simplification smallest sulfoximine thiol thioredoxin trx trx1 vasculature	astragalus barbata bcm berry bioflavonoid coptis coriolus dandelion diinodolymethane eleuthero ganoderma knotweed linteus lucidum mycelium nettle nr2f1 palmetto phellinus plau pomegranate prostacaid pumpkin pygeum sarsaparilla scutellaria sitosterolzinc skullcap stinging
Tagcloud (Difference) ?		1as atg aurothioglucose bpd bronchopulmonary bso buthionine comparatively cysteines cytoprotection h1299 hyperoxia hyperoxic nitrosylation oxidoreductase peroxiredoxin pharmacologically redox relies simplification smallest sulfoximine thiol thioredoxin trx trx1 vasculature	astragalus barbata bcm berry bioflavonoid coptis coriolus dandelion diinodolymethane eleuthero ganoderma knotweed linteus lucidum mycelium nettle nr2f1 palmetto phellinus plau pomegranate prostacaid pumpkin pygeum sarsaparilla scutellaria sitosterolzinc skullcap stinging
Tagcloud (Intersection) ?