HSP90AB1 and UNC45A

Number of citations of the paper that reports this interaction (PubMedID 18285346)
24

Data Source:
BioGRID (pull down)

		HSP90AB1	UNC45A
Description		heat shock protein 90 alpha family class B member 1	unc-45 myosin chaperone A
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane COP9 Signalosome Cell Surface Membrane Protein-containing Complex Aryl Hydrocarbon Receptor Complex Secretory Granule Lumen Melanosome Neuronal Cell Body Dendritic Growth Cone Axonal Growth Cone Perinuclear Region Of Cytoplasm Extracellular Exosome Protein Folding Chaperone Complex Dynein Axonemal Particle Ficolin-1-rich Granule Lumen HSP90-CDC37 Chaperone Complex	Nucleus Cytoplasm Golgi Apparatus Cytosol Nuclear Speck Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding RNA Binding Double-stranded RNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Protein Kinase Regulator Activity Kinase Binding Protein Kinase Binding MHC Class II Protein Complex Binding Nitric-oxide Synthase Regulator Activity TPR Domain Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Peptide Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding ATP-dependent Protein Binding Protein Folding Chaperone Cadherin Binding Protein Dimerization Activity Tau Protein Binding Unfolded Protein Binding DNA Polymerase Binding Protein Phosphatase Activator Activity Disordered Domain Specific Binding ATP-dependent Protein Folding Chaperone Receptor Ligand Inhibitor Activity Histone Methyltransferase Binding	Protein Binding Cadherin Binding Hsp90 Protein Binding
	Biological Process	Placenta Development Protein Folding Response To Unfolded Protein Telomere Maintenance Via Telomerase Virion Attachment To Host Cell Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Cellular Response To Heat Negative Regulation Of Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Differentiation Protein Stabilization Chaperone-mediated Protein Complex Assembly Regulation Of Cell Cycle Cellular Response To Interleukin-4 Supramolecular Fiber Organization Negative Regulation Of Proteasomal Protein Catabolic Process Telomerase Holoenzyme Complex Assembly Positive Regulation Of Protein Localization To Cell Surface	Protein Folding Muscle Organ Development Cell Differentiation
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Regulation of actin dynamics for phagocytic cup formation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand HSF1 activation Attenuation phase HSF1-dependent transactivation Sema3A PAK dependent Axon repulsion Uptake and function of diphtheria toxin Neutrophil degranulation The NLRP3 inflammasome The role of GTSE1 in G2/M progression after G2 checkpoint Aryl hydrocarbon receptor signalling ESR-mediated signaling RHOBTB2 GTPase cycle Estrogen-dependent gene expression Chaperone Mediated Autophagy Purinergic signaling in leishmaniasis infection Potential therapeutics for SARS SARS-CoV-2 activates/modulates innate and adaptive immune responses Assembly and release of respiratory syncytial virus (RSV) virions Respiratory syncytial virus genome replication
Drugs		Geldanamycin 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine Radicicol Tanespimycin SNX-5422 CCT-018159 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE 4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOL (5E)-14-CHLORO-15,17-DIHYDROXY-4,7,8,9,10,11-HEXAHYDRO-2-BENZOXACYCLOPENTADECINE-1,12(3H,13H)-DIONE (5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE (5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE (5Z)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE Polaprezinc
Diseases
GWAS		Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		68 interacting genes: ACD AKT1 ANXA1 ARHGAP1 BTG3 CCT2 CDC37L1 CDK4 CDKN2A CHORDC1 CHUK CLIC4 CSNK2A1 CYP17A1 DDX24 EGFR ENO1 ERBB2 ESR1 ESRRB FCHSD2 GSK3A GSK3B HSPB1 IKBKB IKBKE IKBKG ITGB1BP2 KEAP1 MAP3K14 MAP3K3 MAPK6 MKNK1 MYCBP2 NR2C2 NR3C1 NR4A1 OGT PGR POT1 PPID PTP4A2 RAF1 RHOBTB2 SERPINB5 SGTA SHKBP1 SIRPA SLC34A1 STARD13 STAT1 STAT3 SUMO2 TAF1D TBK1 TERF1 TINF2 TNNT1 TP53 TSSK6 UBE2D3 UBE3A UNC45A USP50 WASL WEE2-AS1 XIAP YWHAB	13 interacting genes: DIRAS2 HSP90AA1 HSP90AB1 KRTAP10-3 LMNA MARCHF10 MAX MEOX1 MEOX2 MID2 PIBF1 SMAD9 TEKT1
Entrez ID		3326	55898
HPRD ID		06763	18070
Ensembl ID		ENSG00000096384	ENSG00000140553
Uniprot IDs		B4DGL0 P08238 Q6PK50	Q9H3U1
PDB IDs		1QZ2 1UYM 2L6J 3FWV 3NMQ 3PRY 3UQ3 5FWK 5FWL 5FWM 5FWP 5UC4 5UCH 5UCI 5UCJ 6N8W 6N8Y 7ULJ 7Z37 7Z38 7ZR0 7ZR5 7ZR6 7ZUB 8EOA 8EOB 8GAE 8GFT 8QMO	2DBA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Kinase Activity Intracellular Signaling Cassette Cytosol Positive Regulation Of Macromolecule Biosynthetic Process Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Intracellular Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of Intracellular Signal Transduction Identical Protein Binding Kinase Activity Nuclear Receptor Activity Negative Regulation Of Macromolecule Metabolic Process Shelterin Complex Protein Serine Kinase Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Proteolysis Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Signal Transduction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Telomere Maintenance Via Telomerase Nuclear Telomere Cap Complex Positive Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process IkappaB Kinase Activity Nucleus Estrogen Response Element Binding Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Catabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Protein Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling	Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Somite Specification Telomerase Holoenzyme Complex Assembly Positive Regulation Of Macromolecule Metabolic Process Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Positive Regulation Of Macromolecule Biosynthetic Process Segment Specification Somite Development Chaperone-mediated Protein Complex Assembly Regulation Of Primary Metabolic Process Telomere Maintenance Via Telomerase DNA Polymerase Binding Axonal Growth Cone RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding Disordered Domain Specific Binding Telomere Maintenance Via Telomere Lengthening Protein Folding Chaperone Complex ATP-dependent Protein Folding Chaperone Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Tau Protein Binding Protein Localization To Cytoskeleton CTP Binding DATP Binding Cellular Response To Heat Protein Folding Chaperone Regulation Of Metabolic Process Embryonic Pattern Specification Regulation Of Nitric Oxide Biosynthetic Process Protein Localization To Organelle Regulation Of Protein Modification Process Regulation Of Nitric Oxide Metabolic Process Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding HSP90-CDC37 Chaperone Complex DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Myc-Max Complex Mad-Max Complex Negative Regulation Of Prostaglandin Biosynthetic Process DNA-binding Transcription Factor Activity
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