RYR2 and SMAD5

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RYR2	SMAD5
Description		ryanodine receptor 2	SMAD family member 5
Image
GO Annotations	Cellular Component	Smooth Endoplasmic Reticulum Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Sarcomere Z Disc Protein-containing Complex Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma	Chromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Protein-containing Complex SMAD Protein Complex Heteromeric SMAD Protein Complex
	Molecular Function	Monoatomic Ion Channel Activity Ryanodine-sensitive Calcium-release Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Intracellularly Gated Calcium Channel Activity Enzyme Binding Protein Kinase Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Identical Protein Binding Suramin Binding Transmembrane Transporter Binding Calcium-induced Calcium Release Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding DEAD/H-box RNA Helicase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding I-SMAD Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Response To Hypoxia Regulation Of Heart Rate Embryonic Heart Tube Morphogenesis Left Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Hypertrophy Detection Of Calcium Ion Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Striated Muscle Contraction Positive Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Muscle Activity Calcium-mediated Signaling Response To Caffeine Monoatomic Ion Transmembrane Transport Response To Muscle Stretch Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Cytosolic Calcium Ion Concentration Establishment Of Localization In Cell Response To Redox State Transmembrane Transport Regulation Of Cardiac Muscle Contraction Cardiac Muscle Contraction Calcium Ion Transport Into Cytosol Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Transmembrane Transport Cellular Response To Caffeine Cellular Response To Epinephrine Stimulus Establishment Of Protein Localization To Endoplasmic Reticulum Ventricular Cardiac Muscle Cell Action Potential Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Type B Pancreatic Cell Apoptotic Process Calcium Ion Transmembrane Import Into Cytosol Positive Regulation Of The Force Of Heart Contraction Regulation Of AV Node Cell Action Potential Regulation Of SA Node Cell Action Potential Regulation Of Atrial Cardiac Muscle Cell Action Potential Regulation Of Ventricular Cardiac Muscle Cell Action Potential	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoblast Differentiation Ureteric Bud Development Mullerian Duct Regression Osteoblast Fate Commitment Cardiac Conduction System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intracellular Iron Ion Homeostasis Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Anatomical Structure Morphogenesis Embryonic Pattern Specification Negative Regulation Of Gene Expression Cell Differentiation Erythrocyte Differentiation BMP Signaling Pathway Developmental Process Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation Cartilage Development Cardiac Muscle Contraction Bone Development SMAD Protein Signal Transduction Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Fas Signaling Pathway Anti-Mullerian Hormone Receptor Signaling Pathway
Pathways		Stimuli-sensing channels Ion homeostasis	Signaling by BMP
Drugs		Flecainide Tetracaine
Diseases		Catecholaminergic polymorphic ventricular tachycardia Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603) Bipolar disorder and eating disorder ( 26433762) Cerivastatin-induced rhabdomyolysis ( 21386754) cognitive impairment (MMSE score) in Parkinson’s disease ( 33613413) Exercise treadmill test traits ( 17903301) General risk tolerance (MTAG) ( 30643258) Hippocampal volume ( 31530798) Hypertension ( 17554300) Lipid traits ( 24386095 30576415) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Postoperative stroke after cardiac surgery ( 30678657) PR interval ( 32439900) Response to taxane treatment (docetaxel) ( 23006423) Smoking initiation (ever regular vs never regular) ( 30679032)	Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Mean platelet volume ( 32888494) Sleep duration (short sleep) ( 30846698)
Interacting Genes		21 interacting genes: AKAP6 ALB CACNA1C CACNA1D FKBP1B HOMER1 HSPB2 ITPR1 JPH3 JPH4 KCNN4 LINC00839 MDM2 PRKACA PRKAR2A PSEN1 RYR1 RYR3 SMAD5 SRI UBE2C	47 interacting genes: ACVR1 ANKRD13A BCAT1 BMP6 CHMP3 COPS5 CXXC5 EP300 FLNA GDF6 HBG2 HGS HOXA13 HOXD13 MBD1 MEN1 MTMR10 NEDD4 PLEKHO1 PNKP POU6F2 PPIL4 PSMD11 PTPN12 RBM4 ROCK1 RYR2 SF3B1 SF3B3 SFPQ SMAD1 SMAD4 SMURF1 SMURF2 SNRNP70 SNRPA SOX5 SOX7 SUV39H1 SUV39H2 TOB1 U2AF2 UBA1 WBP2 WWP1 ZEB2 ZNF8
Entrez ID		6262	4090
HPRD ID		01619	04381
Ensembl ID		ENSG00000198626	ENSG00000113658
Uniprot IDs		Q92736	Q68DB7 Q99717
PDB IDs		4JKQ 6Y4O 6Y4P 7KL5 7U9Q 7U9R 7U9T 7U9X 7U9Z 7UA1 7UA3 7UA4 7UA5 7UA9 8UQ2 8UQ3 8UQ4 8UQ5 8UXC 8UXE 8UXF 8UXG 8UXH 8UXI 8UXL 8UXM	6FZS 6TCE
Enriched GO Terms of Interacting Partners?		Regulation Of Sequestering Of Calcium Ion Calcium Ion Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Transmembrane Transport Regulation Of Metal Ion Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Calcium Ion Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Calcium-mediated Signaling Regulation Of Monoatomic Ion Transport Metal Ion Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Heart Contraction Calcium Channel Complex Z Disc Sarcoplasmic Reticulum Monoatomic Cation Transport Junctional Sarcoplasmic Reticulum Membrane Regulation Of Blood Circulation Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Cardiac Muscle Contraction Calcium Channel Activity Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport System Process Regulation Of Striated Muscle Contraction Monoatomic Ion Transport Regulation Of Heart Rate Inorganic Ion Transmembrane Transport Muscle Contraction Regulation Of Transport Monoatomic Ion Transmembrane Transport Regulation Of System Process Smooth Endoplasmic Reticulum Regulation Of Muscle System Process Muscle System Process Regulation Of Muscle Contraction Protein Tetramerization Sarcoplasmic Reticulum Membrane Intracellularly Gated Calcium Channel Activity Intracellular Signal Transduction T-tubule Positive Regulation Of Transport Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Intracellular Signaling Cassette Calcium Ion Transport Into Cytosol Regulation Of Protein Transport	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process BMP Signaling Pathway SMAD Binding Negative Regulation Of RNA Metabolic Process Chromatin Nucleoplasm Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding Nucleic Acid Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process R-SMAD Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway DNA-templated Transcription Response To Growth Factor Epithelial Cell Migration Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription
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