RYR2 and CACNA1D

Number of citations of the paper that reports this interaction (PubMedID 31461656)
0

Data Source:
BioGRID (fluorescent resonance energy transfer)

		RYR2	CACNA1D
Description		ryanodine receptor 2	calcium voltage-gated channel subunit alpha1 D
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GO Annotations	Cellular Component	Smooth Endoplasmic Reticulum Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Sarcomere Z Disc Protein-containing Complex Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma	Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Z Disc T-tubule Monoatomic Ion Channel Complex L-type Voltage-gated Calcium Channel Complex
	Molecular Function	Monoatomic Ion Channel Activity Ryanodine-sensitive Calcium-release Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Intracellularly Gated Calcium Channel Activity Enzyme Binding Protein Kinase Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Identical Protein Binding Suramin Binding Transmembrane Transporter Binding Calcium-induced Calcium Release Activity	Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding Cytoskeletal Protein Binding High Voltage-gated Calcium Channel Activity Ankyrin Binding Metal Ion Binding Alpha-actinin Binding Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Calcium Channel Activity Involved SA Node Cell Action Potential
	Biological Process	Response To Hypoxia Regulation Of Heart Rate Embryonic Heart Tube Morphogenesis Left Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Hypertrophy Detection Of Calcium Ion Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Striated Muscle Contraction Positive Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Muscle Activity Calcium-mediated Signaling Response To Caffeine Monoatomic Ion Transmembrane Transport Response To Muscle Stretch Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Cytosolic Calcium Ion Concentration Establishment Of Localization In Cell Response To Redox State Transmembrane Transport Regulation Of Cardiac Muscle Contraction Cardiac Muscle Contraction Calcium Ion Transport Into Cytosol Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Transmembrane Transport Cellular Response To Caffeine Cellular Response To Epinephrine Stimulus Establishment Of Protein Localization To Endoplasmic Reticulum Ventricular Cardiac Muscle Cell Action Potential Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Type B Pancreatic Cell Apoptotic Process Calcium Ion Transmembrane Import Into Cytosol Positive Regulation Of The Force Of Heart Contraction Regulation Of AV Node Cell Action Potential Regulation Of SA Node Cell Action Potential Regulation Of Atrial Cardiac Muscle Cell Action Potential Regulation Of Ventricular Cardiac Muscle Cell Action Potential	Monoatomic Ion Transport Calcium Ion Transport Muscle Contraction Cell Communication Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Sound Regulation Of Metal Ion Transport Signaling Monoatomic Ion Transmembrane Transport Positive Regulation Of Adenylate Cyclase Activity Nervous System Process Positive Regulation Of Transport Positive Regulation Of Calcium Ion Transport Transmembrane Transport Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Calcium Ion Import Calcium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Calcium Ion Import Across Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport
Pathways		Stimuli-sensing channels Ion homeostasis	Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion Sensory processing of sound by inner hair cells of the cochlea
Drugs		Flecainide Tetracaine	Ergocalciferol Enflurane Ranolazine Phenytoin Isradipine Topiramate Nimodipine Nisoldipine Spironolactone Cinnarizine Nicardipine Nicardipine Magnesium sulfate Verapamil Levomenthol Ethanol Felodipine Nitrendipine Nitrendipine Miconazole Nifedipine Amiodarone Mibefradil Dronedarone Clevidipine Nilvadipine Nilvadipine Drotaverine Trimebutine Aranidipine Benidipine Cilnidipine Efonidipine Efonidipine Lacidipine Levamlodipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases		Catecholaminergic polymorphic ventricular tachycardia Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603) Bipolar disorder and eating disorder ( 26433762) Cerivastatin-induced rhabdomyolysis ( 21386754) cognitive impairment (MMSE score) in Parkinson’s disease ( 33613413) Exercise treadmill test traits ( 17903301) General risk tolerance (MTAG) ( 30643258) Hippocampal volume ( 31530798) Hypertension ( 17554300) Lipid traits ( 24386095 30576415) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Postoperative stroke after cardiac surgery ( 30678657) PR interval ( 32439900) Response to taxane treatment (docetaxel) ( 23006423) Smoking initiation (ever regular vs never regular) ( 30679032)	Age at first sexual intercourse ( 34211149 27089180) Appendicular lean mass ( 33097823) Axial length ( 24144296) Body mass index ( 25673413) Body size at age 10 ( 32376654) Diastolic blood pressure ( 25249183 30578418 29403010 30487518) Electrocardiographic traits ( 25055868) General risk tolerance (MTAG) ( 30643258) Height ( 28552196) Hypertension ( 25249183 30487518) Insomnia ( 29520036) Insulin resistance/response ( 21901158) Mean arterial pressure ( 29403010 30487518) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) PR interval ( 32439900) Pulse pressure ( 30487518) Pursuit maintenance gain ( 29064472) Refractive error ( 23396134 32231278) Resting heart rate ( 27798624) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 30578418 30487518 25249183 29403010) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 26480920)
Interacting Genes		21 interacting genes: AKAP6 ALB CACNA1C CACNA1D FKBP1B HOMER1 HSPB2 ITPR1 JPH3 JPH4 KCNN4 LINC00839 MDM2 PRKACA PRKAR2A PSEN1 RYR1 RYR3 SMAD5 SRI UBE2C	7 interacting genes: CALB1 FGFR2 JPH3 JPH4 KCNN4 RYR2 STX1A
Entrez ID		6262	776
HPRD ID		01619	00247
Ensembl ID		ENSG00000198626	ENSG00000157388
Uniprot IDs		Q92736	A0A1B0GUN6 Q01668 Q59GD8
PDB IDs		4JKQ 6Y4O 6Y4P 7KL5 7U9Q 7U9R 7U9T 7U9X 7U9Z 7UA1 7UA3 7UA4 7UA5 7UA9 8UQ2 8UQ3 8UQ4 8UQ5 8UXC 8UXE 8UXF 8UXG 8UXH 8UXI 8UXL 8UXM	3LV3 7UHF 7UHG 8E59 8E5A 8E5B
Enriched GO Terms of Interacting Partners?		Regulation Of Sequestering Of Calcium Ion Calcium Ion Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Transmembrane Transport Regulation Of Metal Ion Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Calcium Ion Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Calcium-mediated Signaling Regulation Of Monoatomic Ion Transport Metal Ion Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Heart Contraction Calcium Channel Complex Z Disc Sarcoplasmic Reticulum Monoatomic Cation Transport Junctional Sarcoplasmic Reticulum Membrane Regulation Of Blood Circulation Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Cardiac Muscle Contraction Calcium Channel Activity Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport System Process Regulation Of Striated Muscle Contraction Monoatomic Ion Transport Regulation Of Heart Rate Inorganic Ion Transmembrane Transport Muscle Contraction Regulation Of Transport Monoatomic Ion Transmembrane Transport Regulation Of System Process Smooth Endoplasmic Reticulum Regulation Of Muscle System Process Muscle System Process Regulation Of Muscle Contraction Protein Tetramerization Sarcoplasmic Reticulum Membrane Intracellularly Gated Calcium Channel Activity Intracellular Signal Transduction T-tubule Positive Regulation Of Transport Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Intracellular Signaling Cassette Calcium Ion Transport Into Cytosol Regulation Of Protein Transport	Junctional Sarcoplasmic Reticulum Membrane Calcium Ion Transport Into Cytosol Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Calcium Ion Transport Calcium Ion Transport Regulation Of Monoatomic Cation Transmembrane Transport Junctional Membrane Complex Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Calcium Ion Transmembrane Import Into Cytosol Regulation Of Metal Ion Transport Regulation Of Striated Muscle Contraction Regulation Of Monoatomic Ion Transport Regulation Of Cell Communication Regulation Of Sequestering Of Calcium Ion Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cytosolic Calcium Ion Concentration Smooth Endoplasmic Reticulum Calcium-mediated Signaling Regulation Of Muscle Contraction Regulation Of System Process Metal Ion Transport Calcium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Regulation Of Heart Contraction Regulation Of Synaptic Plasticity Regulation Of Biological Quality System Process Inorganic Ion Transmembrane Transport Regulation Of Muscle System Process Regulation Of Blood Circulation Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Transport Learning Or Memory Ventricular Cardiac Muscle Tissue Morphogenesis Neuromuscular Process Controlling Balance Cognition Regulation Of Cytosolic Calcium Ion Concentration Cardiac Muscle Tissue Morphogenesis Monoatomic Ion Transport Neuron Projection Metanephric Connecting Tubule Development Kidney Epithelium Development Calcium Ion Binding Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Signaling
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