SMAD5 and HOXD13

Number of citations of the paper that reports this interaction (PubMedID 16087734)
77

Data Source:
HPRD (two hybrid)

		SMAD5	HOXD13
Description		SMAD family member 5	homeobox D13
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Protein-containing Complex SMAD Protein Complex Heteromeric SMAD Protein Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding DEAD/H-box RNA Helicase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding I-SMAD Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoblast Differentiation Ureteric Bud Development Mullerian Duct Regression Osteoblast Fate Commitment Cardiac Conduction System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intracellular Iron Ion Homeostasis Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Anatomical Structure Morphogenesis Embryonic Pattern Specification Negative Regulation Of Gene Expression Cell Differentiation Erythrocyte Differentiation BMP Signaling Pathway Developmental Process Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation Cartilage Development Cardiac Muscle Contraction Bone Development SMAD Protein Signal Transduction Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Fas Signaling Pathway Anti-Mullerian Hormone Receptor Signaling Pathway	Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Pattern Specification Process Anterior/posterior Pattern Specification Gland Morphogenesis Embryonic Limb Morphogenesis Male Genitalia Development Prostate Gland Development Response To Testosterone Limb Morphogenesis Regulation Of Cell Population Proliferation Embryonic Digit Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Embryonic Hindgut Morphogenesis Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Morphogenesis Of An Epithelial Fold Branch Elongation Of An Epithelium Regulation Of Branching Involved In Prostate Gland Morphogenesis
Pathways		Signaling by BMP
Drugs
Diseases			Synpolydactyly Syndactyly Brachydactyly, including: type A; type B; type D; type E Brachydactyly-syndactyly syndrome
GWAS		Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Mean platelet volume ( 32888494) Sleep duration (short sleep) ( 30846698)	Male-pattern baldness ( 28196072)
Interacting Genes		47 interacting genes: ACVR1 ANKRD13A BCAT1 BMP6 CHMP3 COPS5 CXXC5 EP300 FLNA GDF6 HBG2 HGS HOXA13 HOXD13 MBD1 MEN1 MTMR10 NEDD4 PLEKHO1 PNKP POU6F2 PPIL4 PSMD11 PTPN12 RBM4 ROCK1 RYR2 SF3B1 SF3B3 SFPQ SMAD1 SMAD4 SMURF1 SMURF2 SNRNP70 SNRPA SOX5 SOX7 SUV39H1 SUV39H2 TOB1 U2AF2 UBA1 WBP2 WWP1 ZEB2 ZNF8	5 interacting genes: CREBBP MEIS1 SMAD1 SMAD2 SMAD5
Entrez ID		4090	3239
HPRD ID		04381	00872
Ensembl ID		ENSG00000113658	ENSG00000128714
Uniprot IDs		Q68DB7 Q99717	P35453
PDB IDs		6FZS 6TCE
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process BMP Signaling Pathway SMAD Binding Negative Regulation Of RNA Metabolic Process Chromatin Nucleoplasm Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding Nucleic Acid Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process R-SMAD Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway DNA-templated Transcription Response To Growth Factor Epithelial Cell Migration Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription	Transcription Regulator Complex Heteromeric SMAD Protein Complex Embryonic Pattern Specification SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Homomeric SMAD Protein Complex Ureteric Bud Development Mesonephric Epithelium Development Osteoblast Fate Commitment Mesonephric Tubule Development Anti-Mullerian Hormone Receptor Signaling Pathway Kidney Epithelium Development Chromatin Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway DEAD/H-box RNA Helicase Binding Anatomical Structure Morphogenesis Co-SMAD Binding Primary MiRNA Processing Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cardiac Conduction System Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Fate Commitment Positive Regulation Of RNA Metabolic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Tube Development Epithelium Development Intracellular Signaling Cassette MiRNA Processing RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Ubiquitin Protein Ligase Binding Regulation Of Transcription By RNA Polymerase II Response To Growth Factor Tau Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Male Germ Cell Nucleus Positive Regulation Of Biosynthetic Process Cardiac Muscle Tissue Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Intracellular Iron Ion Homeostasis Bone Development Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Chromatin Binding
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