SMAD5 and PLEKHO1

Number of citations of the paper that reports this interaction (PMID 18641638)
21

Data Source:
BioGRID (pull down)

		SMAD5	PLEKHO1
Gene Name		SMAD family member 5	pleckstrin homology domain containing, family O member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Integral Component Of Membrane Protein Complex	Nucleus Cytoplasm Plasma Membrane
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Receptor Signaling Protein Activity Protein Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Ubiquitin Protein Ligase Binding Metal Ion Binding	Protein Binding
	Biological Process	Ureteric Bud Development Mullerian Duct Regression Osteoblast Fate Commitment Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Embryonic Pattern Specification Erythrocyte Differentiation BMP Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Cartilage Development Cardiac Muscle Contraction Bone Development Cellular Response To Organic Cyclic Compound Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways		Signaling by BMP
Drugs
Diseases
GWAS
Protein-Protein Interactions		44 interactors: ACVR1 ANKRD13A BCAT1 BMP6 CHMP3 COPS5 CXXC5 EP300 FLNA GDF6 HBG2 HGS HOXA13 HOXD13 MBD1 MEN1 MTMR10 NEDD4 PLEKHO1 PNKP PPIL4 PSMD11 PTPN12 RBM4 RYR2 SF3B1 SF3B3 SFPQ SMAD1 SMAD4 SMURF1 SMURF2 SNRNP70 SNRPA SOX5 SOX7 SUV39H1 SUV39H2 TOB1 U2AF2 UBA1 WWP1 ZEB2 ZNF8	13 interactors: AKT1 AKT2 C10orf88 CSNK2A1 DNAJB1 FLNB IFI35 PSMC5 RPS20 SMAD5 SMURF1 TRAF6 USP7
Entrez ID		4090	51177
HPRD ID		04381	12217
Ensembl ID		ENSG00000113658	ENSG00000023902
Uniprot IDs		Q68DB7 Q99717	Q53GL0
PDB IDs			3AA1
Enriched GO Terms of Interacting Partners?		BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Gene Expression Positive Regulation Of Gene Expression RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Transforming Growth Factor Beta RNA Biosynthetic Process Regulation Of Signal Transduction Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Signal Transduction Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Tissue Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Ossification Embryonic Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation	Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Cellular Protein Metabolic Process Response To Organic Substance Cellular Response To Stimulus Cellular Response To Organic Substance Peripheral Nervous System Myelin Maintenance Protein Metabolic Process Positive Regulation Of Glycogen Biosynthetic Process Cell Surface Receptor Signaling Pathway Regulation Of Inclusion Body Assembly Regulation Of Protein Catabolic Process Cellular Protein Modification Process Regulation Of Fatty Acid Beta-oxidation Enzyme Linked Receptor Protein Signaling Pathway Myelin Maintenance Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Lipid Transport Response To Stimulus Apoptotic Process Glycogen Biosynthetic Process Regulation Of Cell Cycle Process Protein Polyubiquitination Programmed Cell Death Tissue Development Cell Death Death Regulation Of Proteasomal Protein Catabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation Regulation Of Fatty Acid Transport Positive Regulation Of Glucose Metabolic Process Signal Transduction Cellular Response To Growth Factor Stimulus Protein Ubiquitination Cellular Response To Cytokine Stimulus Myelination In Peripheral Nervous System Positive Regulation Of Glucose Import Positive Regulation Of Protein Catabolic Process Cellular Polysaccharide Biosynthetic Process Response To Growth Factor Regulation Of Glycogen Metabolic Process Schwann Cell Development Protein Modification By Small Protein Conjugation Regulation Of Cellular Protein Metabolic Process Protein Catabolic Process Positive Regulation Of Glucose Transport Polysaccharide Biosynthetic Process Positive Regulation Of Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Signaling
Tagcloud ?		1beta affecting alkaloid anticancer bcl caspases cdk1 compound cytokines cytotoxicity g0 g1 inducing k562 lamd lamellarin leukemia marine p27 panel poorly pronounced smad3 stgc3 survivin tgf thinking understood way
Tagcloud (Difference) ?		1beta affecting alkaloid anticancer bcl caspases cdk1 compound cytokines cytotoxicity g0 g1 inducing k562 lamd lamellarin leukemia marine p27 panel poorly pronounced smad3 stgc3 survivin tgf thinking understood way
Tagcloud (Intersection) ?