RYR2 and ITPR1

Number of citations of the paper that reports this interaction (PMID 12754204)
5

Data Source:
HPRD (in vivo)

		RYR2	ITPR1
Gene Name		ryanodine receptor 2 (cardiac)	inositol 1,4,5-trisphosphate receptor, type 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Smooth Endoplasmic Reticulum Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Z Disc Sarcoplasmic Reticulum Membrane Calcium Channel Complex Protein Complex Extracellular Vesicular Exosome	Nuclear Inner Membrane Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Calcineurin Complex Postsynaptic Density Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Platelet Dense Granule Membrane Platelet Dense Tubular Network Platelet Dense Tubular Network Membrane
	Molecular Function	Intracellular Ligand-gated Calcium Channel Activity Ryanodine-sensitive Calcium-release Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-release Channel Activity Enzyme Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Identical Protein Binding Protein Self-association Suramin Binding Ion Channel Binding Calcium-induced Calcium Release Activity	Intracellular Ligand-gated Calcium Channel Activity Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Binding Calcium Ion Transmembrane Transporter Activity Calcium Channel Inhibitor Activity Phosphatidylinositol Binding
	Biological Process	Response To Hypoxia Regulation Of Heart Rate Embryonic Heart Tube Morphogenesis Left Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Hypertrophy Detection Of Calcium Ion Calcium Ion Transport Cellular Calcium Ion Homeostasis Positive Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling BMP Signaling Pathway Response To Caffeine Ion Transmembrane Transport Calcium-mediated Signaling Using Intracellular Calcium Source Response To Muscle Stretch Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Sequestering Of Calcium Ion Cytosolic Calcium Ion Homeostasis Response To Redox State Transmembrane Transport Regulation Of Cardiac Muscle Contraction Cardiac Muscle Contraction Canonical Wnt Signaling Pathway Calcium Ion Transport Into Cytosol Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Transmembrane Transport Cellular Response To Caffeine Cellular Response To Epinephrine Stimulus Establishment Of Protein Localization To Endoplasmic Reticulum Ventricular Cardiac Muscle Cell Action Potential Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity By Adrenergic Receptor Signaling Pathway Involved In Positive Regulation Of Cardiac Muscle Contraction Type B Pancreatic Cell Apoptotic Process Positive Regulation Of The Force Of Heart Contraction Positive Regulation Of Calcium-transporting ATPase Activity	Response To Hypoxia Energy Reserve Metabolic Process Calcium Ion Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Post-embryonic Development Platelet Activation Endoplasmic Reticulum Calcium Ion Homeostasis Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Negative Regulation Of Calcium-mediated Signaling Voluntary Musculoskeletal Movement Release Of Sequestered Calcium Ion Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport
Pathways		Ion channel transport Stimuli-sensing channels	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Phospholipase C-mediated cascade Signaling by FGFR in disease Integration of energy metabolism cGMP effects Signaling by Wnt Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Effects of PIP2 hydrolysis Platelet calcium homeostasis DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Platelet homeostasis Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Platelet activation, signaling and aggregation Adaptive Immune System G alpha (q) signalling events DAG and IP3 signaling VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Nitric oxide stimulates guanylate cyclase Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF PLC beta mediated events Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by FGFR Ca2+ pathway Elevation of cytosolic Ca2+ levels PLC-gamma1 signalling FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603) Exercise treadmill test traits ( 17903301) Hypertension ( 17554300) Obesity-related traits ( 23251661) Response to cerivastatin ( 21386754) Response to taxane treatment (docetaxel) ( 23006423)	Airflow obstruction ( 22837378) Breast cancer ( 23535729) Obesity-related traits ( 23251661)
Protein-Protein Interactions		14 interactors: AKAP6 ALB CACNA1C CALM1 FKBP1B HOMER1 ITPR1 MDM2 PRKACA PRKAR2A RYR1 RYR3 SMAD5 SRI	29 interactors: AHCYL1 AKT1 ARHGAP1 BANK1 BCL2 CA8 CABP1 CCNB1 CDK1 EPB41L1 ERP44 FKBP1A FYN GRM1 HOMER1 HOMER2 HOMER3 ITPR3 ITPRIP LYN MRVI1 PRKACA PRKCD PRKG1 RHOA RYR2 STARD13 TRPC3 TRPC4
Entrez ID		6262	3708
HPRD ID		01619	00925
Ensembl ID		ENSG00000198626	ENSG00000150995
Uniprot IDs		Q92736	B4DER3 B4DGH1 Q14643 Q59H91
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Ion Homeostasis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Calcium Ion Transport Homeostatic Process Muscle Contraction Regulation Of Ion Transmembrane Transport Muscle System Process Second-messenger-mediated Signaling Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Organic Substance Chemical Homeostasis Response To Organic Cyclic Compound Regulation Of Ion Transport Cytosolic Calcium Ion Homeostasis Regulation Of Cardiac Muscle Contraction Regulation Of Protein Transport Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Cellular Localization Regulation Of Insulin Secretion Regulation Of Establishment Of Protein Localization Regulation Of Striated Muscle Contraction Cellular Metal Ion Homeostasis Regulation Of Peptide Hormone Secretion Regulation Of Intracellular Transport Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Protein Localization Regulation Of Hormone Secretion Response To Organonitrogen Compound Cellular Chemical Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Transport Calcium Ion Transport Into Cytosol Calcium Ion Homeostasis Energy Reserve Metabolic Process Ion Homeostasis Cytosolic Calcium Ion Transport Activation Of Phospholipase C Activity Cellular Response To Stimulus Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Muscle Contraction	Regulation Of Calcium Ion Transport Regulation Of Ion Transport Response To Wounding Vascular Endothelial Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Protein Localization Blood Coagulation Hemostasis Regulation Of Cellular Localization Wound Healing Platelet Activation Cell Activation Regulation Of Transmembrane Transporter Activity Positive Regulation Of Signal Transduction Regulation Of Body Fluid Levels Response To Organonitrogen Compound Regulation Of Intracellular Transport Signaling Regulation Of Platelet Aggregation Cell Communication Response To Organic Substance Response To Organic Cyclic Compound Response To Metal Ion Cellular Response To Stimulus Signal Transduction Neurotrophin TRK Receptor Signaling Pathway G-protein Coupled Glutamate Receptor Signaling Pathway Positive Regulation Of Transport Neurotrophin Signaling Pathway Regulation Of Catalytic Activity Second-messenger-mediated Signaling Regulation Of Ion Transmembrane Transporter Activity Regulation Of Intracellular Signal Transduction Response To Stimulus Regulation Of Ion Homeostasis Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Platelet Activation Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Cell Activation Regulation Of Establishment Of Protein Localization Response To Inorganic Substance Positive Regulation Of Catalytic Activity Regulation Of Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor
Tagcloud ?		12kda atlantic bedford biphenyls congener congeners creek dioxin exceed f2 fk506 fkbp12 fundulus generations heritable heteroclitus hydrocarbon killifish nbh ndl pcb pcbs ryanodine ryr1 scorton serca2 thrive vastly	autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Difference) ?		12kda atlantic bedford biphenyls congener congeners creek dioxin exceed f2 fk506 fkbp12 fundulus generations heritable heteroclitus hydrocarbon killifish nbh ndl pcb pcbs ryanodine ryr1 scorton serca2 thrive vastly	autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Intersection) ?