SMAD5 and SOX7

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		SMAD5	SOX7
Gene Name		SMAD family member 5	SRY (sex determining region Y)-box 7
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Integral Component Of Membrane Protein Complex	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Receptor Signaling Protein Activity Protein Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Ubiquitin Protein Ligase Binding Metal Ion Binding	Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Ureteric Bud Development Mullerian Duct Regression Osteoblast Fate Commitment Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Embryonic Pattern Specification Erythrocyte Differentiation BMP Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Cartilage Development Cardiac Muscle Contraction Bone Development Cellular Response To Organic Cyclic Compound Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus	Endoderm Formation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Canonical Wnt Signaling Pathway
Pathways		Signaling by BMP
Drugs
Diseases
GWAS			Retinal vascular caliber ( 21060863)
Protein-Protein Interactions		44 interactors: ACVR1 ANKRD13A BCAT1 BMP6 CHMP3 COPS5 CXXC5 EP300 FLNA GDF6 HBG2 HGS HOXA13 HOXD13 MBD1 MEN1 MTMR10 NEDD4 PLEKHO1 PNKP PPIL4 PSMD11 PTPN12 RBM4 RYR2 SF3B1 SF3B3 SFPQ SMAD1 SMAD4 SMURF1 SMURF2 SNRNP70 SNRPA SOX5 SOX7 SUV39H1 SUV39H2 TOB1 U2AF2 UBA1 WWP1 ZEB2 ZNF8	4 interactors: APP GLRX3 SMAD5 SMAD7
Entrez ID		4090	83595
HPRD ID		04381	18087
Ensembl ID		ENSG00000113658	ENSG00000171056
Uniprot IDs		Q68DB7 Q99717	Q9BT81
PDB IDs
Enriched GO Terms of Interacting Partners?		BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Gene Expression Positive Regulation Of Gene Expression RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Transforming Growth Factor Beta RNA Biosynthetic Process Regulation Of Signal Transduction Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Signal Transduction Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Tissue Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Ossification Embryonic Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation	BMP Signaling Pathway Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Transforming Growth Factor Beta Receptor Signaling Pathway Kidney Epithelium Development Regulation Of Heart Contraction Positive Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Growth At Neuromuscular Junction Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Collateral Sprouting In Absence Of Injury Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Phosphorylation Positive Regulation Of Transcription, DNA-templated Homeostatic Process Collateral Sprouting Axon Midline Choice Point Recognition Mullerian Duct Regression Positive Regulation Of Proteolysis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Kidney Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Axon Choice Point Recognition Regulation Of Cell Differentiation Renal System Development Negative Regulation Of Cell Development Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription By Competitive Promoter Binding Neuron Remodeling Osteoblast Fate Commitment Urogenital System Development Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Muscle Hypertrophy Phosphorylation Pathway-restricted SMAD Protein Phosphorylation Posttranscriptional Regulation Of Gene Expression Cellular Protein Complex Localization Regulation Of Cellular Ketone Metabolic Process Anatomical Structure Regression Response To Laminar Fluid Shear Stress Negative Regulation Of Peptidyl-threonine Phosphorylation Cellular Copper Ion Homeostasis Protein Complex Localization
Tagcloud ?		1beta affecting alkaloid anticancer bcl caspases cdk1 compound cytokines cytotoxicity g0 g1 inducing k562 lamd lamellarin leukemia marine p27 panel poorly pronounced smad3 stgc3 survivin tgf thinking understood way	anchorage bioinformatics box carcinogenesis determining downregulation ectopic emerged kinds luciferase messenger microrna micrornas mir mirnas onco participates promoted regulators repressed silenced sum suppressing translational tumorigenesis untranslated utr y zr
Tagcloud (Difference) ?		1beta affecting alkaloid anticancer bcl caspases cdk1 compound cytokines cytotoxicity g0 g1 inducing k562 lamd lamellarin leukemia marine p27 panel poorly pronounced smad3 stgc3 survivin tgf thinking understood way	anchorage bioinformatics box carcinogenesis determining downregulation ectopic emerged kinds luciferase messenger microrna micrornas mir mirnas onco participates promoted regulators repressed silenced sum suppressing translational tumorigenesis untranslated utr y zr
Tagcloud (Intersection) ?