RYR2 and ALB

Number of citations of the paper that reports this interaction (PMID 15174051)
39

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		RYR2	ALB
Gene Name		ryanodine receptor 2 (cardiac)	albumin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Smooth Endoplasmic Reticulum Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Z Disc Sarcoplasmic Reticulum Membrane Calcium Channel Complex Protein Complex Extracellular Vesicular Exosome	Extracellular Region Basement Membrane Extracellular Space Nucleus Platelet Alpha Granule Lumen Protein Complex Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Intracellular Ligand-gated Calcium Channel Activity Ryanodine-sensitive Calcium-release Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-release Channel Activity Enzyme Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Identical Protein Binding Protein Self-association Suramin Binding Ion Channel Binding Calcium-induced Calcium Release Activity	DNA Binding Fatty Acid Binding Copper Ion Binding Protein Binding Drug Binding Zinc Ion Binding Toxic Substance Binding Antioxidant Activity Oxygen Binding Enzyme Binding Pyridoxal Phosphate Binding Chaperone Binding
	Biological Process	Response To Hypoxia Regulation Of Heart Rate Embryonic Heart Tube Morphogenesis Left Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Hypertrophy Detection Of Calcium Ion Calcium Ion Transport Cellular Calcium Ion Homeostasis Positive Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling BMP Signaling Pathway Response To Caffeine Ion Transmembrane Transport Calcium-mediated Signaling Using Intracellular Calcium Source Response To Muscle Stretch Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Sequestering Of Calcium Ion Cytosolic Calcium Ion Homeostasis Response To Redox State Transmembrane Transport Regulation Of Cardiac Muscle Contraction Cardiac Muscle Contraction Canonical Wnt Signaling Pathway Calcium Ion Transport Into Cytosol Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Transmembrane Transport Cellular Response To Caffeine Cellular Response To Epinephrine Stimulus Establishment Of Protein Localization To Endoplasmic Reticulum Ventricular Cardiac Muscle Cell Action Potential Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity By Adrenergic Receptor Signaling Pathway Involved In Positive Regulation Of Cardiac Muscle Contraction Type B Pancreatic Cell Apoptotic Process Positive Regulation Of The Force Of Heart Contraction Positive Regulation Of Calcium-transporting ATPase Activity	Retina Homeostasis Platelet Degranulation Transport Receptor-mediated Endocytosis Response To Nutrient Blood Coagulation Bile Acid Metabolic Process Cellular Response To Starvation Response To Organic Substance Bile Acid And Bile Salt Transport Hemolysis By Symbiont Of Host Erythrocytes Platelet Activation Lipoprotein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Sodium-independent Organic Anion Transport Small Molecule Metabolic Process Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Response To Mercury Ion Maintenance Of Mitochondrion Location Transmembrane Transport Response To Platinum Ion
Pathways		Ion channel transport Stimuli-sensing channels	Lipoprotein metabolism Bile acid and bile salt metabolism Metabolism of lipids and lipoproteins Recycling of bile acids and salts Platelet degranulation Lipid digestion, mobilization, and transport Transport of organic anions SLC-mediated transmembrane transport HDL-mediated lipid transport Scavenging of heme from plasma Response to elevated platelet cytosolic Ca2+ Platelet activation, signaling and aggregation Transport of vitamins, nucleosides, and related molecules
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603) Exercise treadmill test traits ( 17903301) Hypertension ( 17554300) Obesity-related traits ( 23251661) Response to cerivastatin ( 21386754) Response to taxane treatment (docetaxel) ( 23006423)	Lipid metabolism phenotypes ( 22286219) Prostate cancer ( 23535732)
Protein-Protein Interactions		14 interactors: AKAP6 ALB CACNA1C CALM1 FKBP1B HOMER1 ITPR1 MDM2 PRKACA PRKAR2A RYR1 RYR3 SMAD5 SRI	24 interactors: AGA AMBP APOE APP CRYAA CUBN F7 FCGRT HNF1A IMMT KLK3 LRP2 LUC7L2 NR5A2 ORM1 PFDN1 PON1 PRB3 RBP4 RYR2 SRGN ST13 TK1 YWHAG
Entrez ID		6262	213
HPRD ID		01619	00062
Ensembl ID		ENSG00000198626	ENSG00000163631
Uniprot IDs		Q92736	C9JKR2 P02768
PDB IDs			1AO6 1BJ5 1BKE 1BM0 1E78 1E7A 1E7B 1E7C 1E7E 1E7F 1E7G 1E7H 1E7I 1GNI 1GNJ 1H9Z 1HA2 1HK1 1HK2 1HK3 1HK4 1HK5 1N5U 1O9X 1TF0 1UOR 1YSX 2BX8 2BXA 2BXB 2BXC 2BXD 2BXE 2BXF 2BXG 2BXH 2BXI 2BXK 2BXL 2BXM 2BXN 2BXO 2BXP 2BXQ 2ESG 2I2Z 2I30 2VDB 2VUE 2VUF 2XSI 2XVQ 2XVU 2XVV 2XVW 2XW0 2XW1 2YDF 3A73 3B9L 3B9M 3CX9 3JQZ 3JRY 3LU6 3LU7 3LU8 3SQJ 3TDL 3UIV 4E99 4EMX 4G03 4G04 4HGK 4HGM 4IW1 4IW2 4K2C 4L8U 4L9K 4L9Q 4LA0 4LB2 4LB9
Enriched GO Terms of Interacting Partners?		Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Ion Homeostasis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Calcium Ion Transport Homeostatic Process Muscle Contraction Regulation Of Ion Transmembrane Transport Muscle System Process Second-messenger-mediated Signaling Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Organic Substance Chemical Homeostasis Response To Organic Cyclic Compound Regulation Of Ion Transport Cytosolic Calcium Ion Homeostasis Regulation Of Cardiac Muscle Contraction Regulation Of Protein Transport Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Cellular Localization Regulation Of Insulin Secretion Regulation Of Establishment Of Protein Localization Regulation Of Striated Muscle Contraction Cellular Metal Ion Homeostasis Regulation Of Peptide Hormone Secretion Regulation Of Intracellular Transport Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Protein Localization Regulation Of Hormone Secretion Response To Organonitrogen Compound Cellular Chemical Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Transport Calcium Ion Transport Into Cytosol Calcium Ion Homeostasis Energy Reserve Metabolic Process Ion Homeostasis Cytosolic Calcium Ion Transport Activation Of Phospholipase C Activity Cellular Response To Stimulus Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Muscle Contraction	Alcohol Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Chemical Homeostasis Lipid Metabolic Process Homeostatic Process Response To External Stimulus Response To Stimulus Phototransduction, Visible Light Retinoid Metabolic Process Tetrapyrrole Metabolic Process Vitamin D Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Regulation Of Blood Coagulation Response To Lipid Positive Regulation Of Cholesterol Efflux Reverse Cholesterol Transport Detection Of Light Stimulus Positive Regulation Of Cholesterol Transport Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis System Development Isoprenoid Metabolic Process Small Molecule Metabolic Process Regulation Of Cholesterol Efflux Response To Hormone Regulation Of Wound Healing Organ Development Response To Light Stimulus Vesicle-mediated Transport Receptor-mediated Endocytosis Endocytosis Regulation Of Cellular Localization Response To Organic Substance Response To Wounding Response To Abiotic Stimulus Cellular Metal Ion Homeostasis Positive Regulation Of Transport Bile Acid Metabolic Process Detection Of Abiotic Stimulus Regulation Of Cholesterol Transport Blood Coagulation Tissue Homeostasis Hemostasis Response To Nutrient Levels Heme Metabolic Process Multicellular Organismal Development
Tagcloud ?		12kda atlantic bedford biphenyls congener congeners creek dioxin exceed f2 fk506 fkbp12 fundulus generations heritable heteroclitus hydrocarbon killifish nbh ndl pcb pcbs ryanodine ryr1 scorton serca2 thrive vastly	ambulatory anabolic anthropometric calls capd catabolism causal complicating declined deterioration dialysis haemodialysis instead malnutrition mmol nutrineal nutrition osmotic peritoneal phosphates phosphorus rule solution substituted termination transferrin uraemic urea wilcoxon
Tagcloud (Difference) ?		12kda atlantic bedford biphenyls congener congeners creek dioxin exceed f2 fk506 fkbp12 fundulus generations heritable heteroclitus hydrocarbon killifish nbh ndl pcb pcbs ryanodine ryr1 scorton serca2 thrive vastly	ambulatory anabolic anthropometric calls capd catabolism causal complicating declined deterioration dialysis haemodialysis instead malnutrition mmol nutrineal nutrition osmotic peritoneal phosphates phosphorus rule solution substituted termination transferrin uraemic urea wilcoxon
Tagcloud (Intersection) ?