SMAD5 and CXXC5

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		SMAD5	CXXC5
Gene Name		SMAD family member 5	CXXC finger protein 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Integral Component Of Membrane Protein Complex	Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Receptor Signaling Protein Activity Protein Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Ubiquitin Protein Ligase Binding Metal Ion Binding	DNA Binding Signal Transducer Activity Zinc Ion Binding
	Biological Process	Ureteric Bud Development Mullerian Duct Regression Osteoblast Fate Commitment Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Embryonic Pattern Specification Erythrocyte Differentiation BMP Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Cartilage Development Cardiac Muscle Contraction Bone Development Cellular Response To Organic Cyclic Compound Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus	Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pathways		Signaling by BMP
Drugs
Diseases
GWAS
Protein-Protein Interactions		44 interactors: ACVR1 ANKRD13A BCAT1 BMP6 CHMP3 COPS5 CXXC5 EP300 FLNA GDF6 HBG2 HGS HOXA13 HOXD13 MBD1 MEN1 MTMR10 NEDD4 PLEKHO1 PNKP PPIL4 PSMD11 PTPN12 RBM4 RYR2 SF3B1 SF3B3 SFPQ SMAD1 SMAD4 SMURF1 SMURF2 SNRNP70 SNRPA SOX5 SOX7 SUV39H1 SUV39H2 TOB1 U2AF2 UBA1 WWP1 ZEB2 ZNF8	7 interactors: ATM SKIL SMAD3 SMAD5 SMAD7 SMAD9 VDR
Entrez ID		4090	51523
HPRD ID		04381	13105
Ensembl ID		ENSG00000113658	ENSG00000171604
Uniprot IDs		Q68DB7 Q99717	Q7LFL8
PDB IDs
Enriched GO Terms of Interacting Partners?		BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Gene Expression Positive Regulation Of Gene Expression RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Transforming Growth Factor Beta RNA Biosynthetic Process Regulation Of Signal Transduction Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Signal Transduction Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Tissue Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Ossification Embryonic Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation	Transforming Growth Factor Beta Receptor Signaling Pathway Epithelium Development Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Tissue Development Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Kidney Epithelium Development Transcription Initiation From RNA Polymerase II Promoter Anatomical Structure Morphogenesis Cellular Response To Growth Factor Stimulus Response To Growth Factor DNA-templated Transcription, Initiation Tube Development Organ Development Regulation Of Cell Differentiation Mullerian Duct Regression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Kidney Development RNA Metabolic Process BMP Signaling Pathway Renal System Development Positive Regulation Of Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Urogenital System Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Organic Cyclic Compound Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus System Development Transcription, DNA-templated Single Organism Reproductive Process RNA Biosynthetic Process Cell Cycle Arrest Anatomical Structure Regression Response To Organic Substance Skeletal System Development Reproductive Process Positive Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Multicellular Organismal Development Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Death
Tagcloud ?		1beta affecting alkaloid anticancer bcl caspases cdk1 compound cytokines cytotoxicity g0 g1 inducing k562 lamd lamellarin leukemia marine p27 panel poorly pronounced smad3 stgc3 survivin tgf thinking understood way	450k bnc1 clinicopathologic clustering comprehensively cpg cyb5r2 cytosine densities dysregulation false fzd1 harbors hierarchical il1 illumina inactivation interrogating intraepithelial lmx1b methylated methylation myriad pca prostatic rpl39l syn2 top znf783
Tagcloud (Difference) ?		1beta affecting alkaloid anticancer bcl caspases cdk1 compound cytokines cytotoxicity g0 g1 inducing k562 lamd lamellarin leukemia marine p27 panel poorly pronounced smad3 stgc3 survivin tgf thinking understood way	450k bnc1 clinicopathologic clustering comprehensively cpg cyb5r2 cytosine densities dysregulation false fzd1 harbors hierarchical il1 illumina inactivation interrogating intraepithelial lmx1b methylated methylation myriad pca prostatic rpl39l syn2 top znf783
Tagcloud (Intersection) ?