SMAD5 and ZEB2

Number of citations of the paper that reports this interaction (PubMedID 10400677)
0

Data Source:
HPRD (two hybrid)

		SMAD5	ZEB2
Description		SMAD family member 5	zinc finger E-box binding homeobox 2
Image
GO Annotations	Cellular Component	Chromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Protein-containing Complex SMAD Protein Complex Heteromeric SMAD Protein Complex	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Plasma Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding DEAD/H-box RNA Helicase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding I-SMAD Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Phosphatase Regulator Activity Metal Ion Binding R-SMAD Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoblast Differentiation Ureteric Bud Development Mullerian Duct Regression Osteoblast Fate Commitment Cardiac Conduction System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intracellular Iron Ion Homeostasis Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Anatomical Structure Morphogenesis Embryonic Pattern Specification Negative Regulation Of Gene Expression Cell Differentiation Erythrocyte Differentiation BMP Signaling Pathway Developmental Process Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation Cartilage Development Cardiac Muscle Contraction Bone Development SMAD Protein Signal Transduction Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Fas Signaling Pathway Anti-Mullerian Hormone Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Somitogenesis Neural Tube Closure Endothelial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Nervous System Development Central Nervous System Development Negative Regulation Of Fibroblast Migration Corpus Callosum Morphogenesis Hippocampus Development Cell Proliferation In Forebrain Corticospinal Tract Morphogenesis Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Myofibroblast Differentiation Stress Fiber Assembly Endothelial Cell Migration Positive Regulation Of Melanocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Melanin Biosynthetic Process Developmental Pigmentation Astrocyte Activation Embryonic Morphogenesis Collateral Sprouting Positive Regulation Of Axonogenesis Mammillary Axonal Complex Development Pyroptotic Inflammatory Response Fibroblast Activation Positive Regulation Of Canonical Wnt Signaling Pathway Response To Oxygen-glucose Deprivation Melanocyte Migration Positive Regulation Of Lens Fiber Cell Differentiation Regulation Of Melanosome Organization Positive Regulation Of Myofibroblast Contraction Regulation Of Myofibroblast Cell Apoptotic Process Regulation Of Blood-brain Barrier Permeability
Pathways		Signaling by BMP	Regulation of CDH11 gene transcription Regulation of CDH11 gene transcription Negative Regulation of CDH1 Gene Transcription Positive Regulation of CDH1 Gene Transcription Formation of the anterior neural plate Formation of the posterior neural plate
Drugs
Diseases			Mowat-Wilson syndrome
GWAS		Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Mean platelet volume ( 32888494) Sleep duration (short sleep) ( 30846698)	Adult body size ( 32376654) Adventurousness ( 30643258) Age-related nuclear cataracts ( 33311586) Childhood absence epilepsy ( 30531953) Chin dimples ( 27182965) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Corneal astigmatism ( 30306274) Coronary artery disease ( 29212778 32469254 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) General risk tolerance (MTAG) ( 30643258) Generalized epilepsy ( 22949513) Hand grip strength ( 29691431) High myopia ( 31816047) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010) Medication use (diuretics) ( 31015401) Myocardial infarction ( 33532862 26343387) Obesity-related traits ( 23251661) Photic sneeze reflex ( 30899065 27182965) Red blood cell count ( 29403010) Refractive error ( 32231278) Renal cell carcinoma ( 25826619 23184150) Retinal detachment or retinal break ( 31816047) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 29483656 23974872) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 32203549)
Interacting Genes		47 interacting genes: ACVR1 ANKRD13A BCAT1 BMP6 CHMP3 COPS5 CXXC5 EP300 FLNA GDF6 HBG2 HGS HOXA13 HOXD13 MBD1 MEN1 MTMR10 NEDD4 PLEKHO1 PNKP POU6F2 PPIL4 PSMD11 PTPN12 RBM4 ROCK1 RYR2 SF3B1 SF3B3 SFPQ SMAD1 SMAD4 SMURF1 SMURF2 SNRNP70 SNRPA SOX5 SOX7 SUV39H1 SUV39H2 TOB1 U2AF2 UBA1 WBP2 WWP1 ZEB2 ZNF8	16 interacting genes: APP CBX4 COPS6 CTBP1 CTBP2 DDB1 DGKG FBXO45 MTA1 SMAD1 SMAD2 SMAD3 SMAD5 SMAD9 UBE2I USP16
Entrez ID		4090	9839
HPRD ID		04381	05780
Ensembl ID		ENSG00000113658	ENSG00000169554
Uniprot IDs		Q68DB7 Q99717	O60315
PDB IDs		6FZS 6TCE	2DA7
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process BMP Signaling Pathway SMAD Binding Negative Regulation Of RNA Metabolic Process Chromatin Nucleoplasm Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding Nucleic Acid Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process R-SMAD Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway DNA-templated Transcription Response To Growth Factor Epithelial Cell Migration Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription	SMAD Protein Complex Heteromeric SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway DEAD/H-box RNA Helicase Binding Ureteric Bud Development Mesonephric Epithelium Development Mesonephric Tubule Development Co-SMAD Binding Primary MiRNA Processing Embryonic Pattern Specification Response To Growth Factor Regulation Of Transcription By RNA Polymerase II Kidney Epithelium Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Homomeric SMAD Protein Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Fate Commitment Paraxial Mesoderm Morphogenesis Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Transcription Regulator Complex MiRNA Processing Chromatin Binding Regulation Of DNA-templated Transcription Cellular Response To Growth Factor Stimulus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Biosynthetic Process Osteoblast Differentiation Regulation Of Macromolecule Metabolic Process Anti-Mullerian Hormone Receptor Signaling Pathway Mesoderm Morphogenesis Transcription Coregulator Binding Regulation Of Gene Expression Nucleoplasm Positive Regulation Of Biosynthetic Process Pericardium Development Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Binding Regulation Of RNA Metabolic Process
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