RYR2 and JPH4

Number of citations of the paper that reports this interaction (PubMedID 31461656)
0

Data Source:
BioGRID (fluorescent resonance energy transfer)

		RYR2	JPH4
Description		ryanodine receptor 2	junctophilin 4
Image			No pdb structure
GO Annotations	Cellular Component	Smooth Endoplasmic Reticulum Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Sarcomere Z Disc Protein-containing Complex Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Junctional Membrane Complex Dendritic Shaft
	Molecular Function	Monoatomic Ion Channel Activity Ryanodine-sensitive Calcium-release Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Intracellularly Gated Calcium Channel Activity Enzyme Binding Protein Kinase Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Identical Protein Binding Suramin Binding Transmembrane Transporter Binding Calcium-induced Calcium Release Activity	Protein Binding
	Biological Process	Response To Hypoxia Regulation Of Heart Rate Embryonic Heart Tube Morphogenesis Left Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Hypertrophy Detection Of Calcium Ion Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Striated Muscle Contraction Positive Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Muscle Activity Calcium-mediated Signaling Response To Caffeine Monoatomic Ion Transmembrane Transport Response To Muscle Stretch Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Cytosolic Calcium Ion Concentration Establishment Of Localization In Cell Response To Redox State Transmembrane Transport Regulation Of Cardiac Muscle Contraction Cardiac Muscle Contraction Calcium Ion Transport Into Cytosol Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Transmembrane Transport Cellular Response To Caffeine Cellular Response To Epinephrine Stimulus Establishment Of Protein Localization To Endoplasmic Reticulum Ventricular Cardiac Muscle Cell Action Potential Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Type B Pancreatic Cell Apoptotic Process Calcium Ion Transmembrane Import Into Cytosol Positive Regulation Of The Force Of Heart Contraction Regulation Of AV Node Cell Action Potential Regulation Of SA Node Cell Action Potential Regulation Of Atrial Cardiac Muscle Cell Action Potential Regulation Of Ventricular Cardiac Muscle Cell Action Potential	Regulation Of Cytokine Production Learning Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Synaptic Plasticity Neuromuscular Process Controlling Balance Calcium Ion Transport Into Cytosol Regulation Of Store-operated Calcium Entry
Pathways		Stimuli-sensing channels Ion homeostasis
Drugs		Flecainide Tetracaine
Diseases		Catecholaminergic polymorphic ventricular tachycardia Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603) Bipolar disorder and eating disorder ( 26433762) Cerivastatin-induced rhabdomyolysis ( 21386754) cognitive impairment (MMSE score) in Parkinson’s disease ( 33613413) Exercise treadmill test traits ( 17903301) General risk tolerance (MTAG) ( 30643258) Hippocampal volume ( 31530798) Hypertension ( 17554300) Lipid traits ( 24386095 30576415) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Postoperative stroke after cardiac surgery ( 30678657) PR interval ( 32439900) Response to taxane treatment (docetaxel) ( 23006423) Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes		21 interacting genes: AKAP6 ALB CACNA1C CACNA1D FKBP1B HOMER1 HSPB2 ITPR1 JPH3 JPH4 KCNN4 LINC00839 MDM2 PRKACA PRKAR2A PSEN1 RYR1 RYR3 SMAD5 SRI UBE2C	6 interacting genes: BCL2L13 CACNA1D KCNN4 RYR2 UBQLN1 UBQLN2
Entrez ID		6262	84502
HPRD ID		01619	17170
Ensembl ID		ENSG00000198626	ENSG00000092051
Uniprot IDs		Q92736	Q96JJ6
PDB IDs		4JKQ 6Y4O 6Y4P 7KL5 7U9Q 7U9R 7U9T 7U9X 7U9Z 7UA1 7UA3 7UA4 7UA5 7UA9 8UQ2 8UQ3 8UQ4 8UQ5 8UXC 8UXE 8UXF 8UXG 8UXH 8UXI 8UXL 8UXM
Enriched GO Terms of Interacting Partners?		Regulation Of Sequestering Of Calcium Ion Calcium Ion Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Transmembrane Transport Regulation Of Metal Ion Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Calcium Ion Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Calcium-mediated Signaling Regulation Of Monoatomic Ion Transport Metal Ion Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Heart Contraction Calcium Channel Complex Z Disc Sarcoplasmic Reticulum Monoatomic Cation Transport Junctional Sarcoplasmic Reticulum Membrane Regulation Of Blood Circulation Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Cardiac Muscle Contraction Calcium Channel Activity Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport System Process Regulation Of Striated Muscle Contraction Monoatomic Ion Transport Regulation Of Heart Rate Inorganic Ion Transmembrane Transport Muscle Contraction Regulation Of Transport Monoatomic Ion Transmembrane Transport Regulation Of System Process Smooth Endoplasmic Reticulum Regulation Of Muscle System Process Muscle System Process Regulation Of Muscle Contraction Protein Tetramerization Sarcoplasmic Reticulum Membrane Intracellularly Gated Calcium Channel Activity Intracellular Signal Transduction T-tubule Positive Regulation Of Transport Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Intracellular Signaling Cassette Calcium Ion Transport Into Cytosol Regulation Of Protein Transport	Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Calcium Ion Transport Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Regulation Of Transport Calcium Ion Transport Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Action Potential Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Autophagy Regulation Of Potassium Ion Transmembrane Transport Calcium Channel Activity Regulation Of Membrane Potential Regulation Of Potassium Ion Transport Intermediate Conductance Calcium-activated Potassium Channel Activity Autophagosome Negative Regulation Of Store-operated Calcium Channel Activity Calcium Ion Transmembrane Import Into Cytosol Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Regulation Of Heart Rate Autophagosome Organization Action Potential Voltage-gated Calcium Channel Activity Involved SA Node Cell Action Potential Suramin Binding Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteasomal Protein Catabolic Process Metal Ion Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Z Disc Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Stabilization Of Membrane Potential Ryanodine-sensitive Calcium-release Channel Activity Type B Pancreatic Cell Apoptotic Process Regulation Of AV Node Cell Action Potential Left Ventricular Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Inorganic Ion Transmembrane Transport Macroautophagy Monoatomic Ion Channel Activity Small Conductance Calcium-activated Potassium Channel Activity
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