SMAD5 and SNRPA

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SMAD5	SNRPA
Gene Name		SMAD family member 5	small nuclear ribonucleoprotein polypeptide A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Integral Component Of Membrane Protein Complex	Nucleoplasm Spliceosomal Complex U1 SnRNP Nucleolus Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Receptor Signaling Protein Activity Protein Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Ubiquitin Protein Ligase Binding Metal Ion Binding	Nucleotide Binding RNA Binding Protein Binding SnRNA Binding Poly(A) RNA Binding
	Biological Process	Ureteric Bud Development Mullerian Duct Regression Osteoblast Fate Commitment Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Embryonic Pattern Specification Erythrocyte Differentiation BMP Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Cartilage Development Cardiac Muscle Contraction Bone Development Cellular Response To Organic Cyclic Compound Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus	MRNA Splicing, Via Spliceosome RNA Splicing Gene Expression
Pathways		Signaling by BMP	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		44 interactors: ACVR1 ANKRD13A BCAT1 BMP6 CHMP3 COPS5 CXXC5 EP300 FLNA GDF6 HBG2 HGS HOXA13 HOXD13 MBD1 MEN1 MTMR10 NEDD4 PLEKHO1 PNKP PPIL4 PSMD11 PTPN12 RBM4 RYR2 SF3B1 SF3B3 SFPQ SMAD1 SMAD4 SMURF1 SMURF2 SNRNP70 SNRPA SOX5 SOX7 SUV39H1 SUV39H2 TOB1 U2AF2 UBA1 WWP1 ZEB2 ZNF8	27 interactors: C19orf43 CDKN2A CIRBP ENOX2 GABPB1 HNRNPK IL7R LENG8 METTL13 MTUS2 NDUFAF3 PAPOLA PCBP1 PCBP2 PTBP1 PTBP2 QKI RBM3 RBM42 RBMX SFPQ SMAD5 SNRPA1 TRIM27 U2AF2 UBC WBP4
Entrez ID		4090	6626
HPRD ID		04381	01658
Ensembl ID		ENSG00000113658	ENSG00000077312
Uniprot IDs		Q68DB7 Q99717	B4DDC7 P09012
PDB IDs			1AUD 1CX0 1DRZ 1DZ5 1FHT 1M5K 1M5O 1M5P 1M5V 1NU4 1OIA 1SJ3 1SJ4 1SJF 1U6B 1URN 1VBX 1VBY 1VBZ 1VC0 1VC5 1VC6 1VC7 1ZZN 2A3J 2NZ4 2OIH 2OJ3 2U1A 3BO2 3BO3 3BO4 3CUL 3CUN 3EGZ 3G8S 3G8T 3G96 3G9C 3HHN 3IIN 3IRW 3IWN 3K0J 3L3C 3MUM 3MUR 3MUT 3MUV 3MXH 3P49 3PGW 3R1H 3R1L 3UCU 3UCZ 3UD3 3UD4 3UTR
Enriched GO Terms of Interacting Partners?		BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Gene Expression Positive Regulation Of Gene Expression RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Transforming Growth Factor Beta RNA Biosynthetic Process Regulation Of Signal Transduction Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Signal Transduction Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Tissue Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Ossification Embryonic Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing RNA Processing MRNA Processing MRNA Metabolic Process Negative Regulation Of RNA Splicing RNA Metabolic Process Gene Expression Negative Regulation Of MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Regulation Of MRNA Processing Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immune System Process Positive Regulation Of Cellular Metabolic Process Protein K63-linked Ubiquitination Positive Regulation Of RNA Splicing Negative Regulation Of Adaptive Immune Response Protein Polyubiquitination Termination Of RNA Polymerase II Transcription Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Type I Interferon Production Biosynthetic Process Ultradian Rhythm Negative Regulation Of Cytokine Production Cellular Metabolic Process Regulation Of MRNA Stability
Tagcloud ?		1beta affecting alkaloid anticancer bcl caspases cdk1 compound cytokines cytotoxicity g0 g1 inducing k562 lamd lamellarin leukemia marine p27 panel poorly pronounced smad3 stgc3 survivin tgf thinking understood way	adh1c aldh6a1 aldob apom ces1 fads1 ftl glo1 hemopexin hnrpdl loc644587 lrrc28 methylglyoxal orosomucoid pabpc1 pla2g10 polr2k rpl14 rpl41 rpl8 rps17 rps24 rps5 srp9 ssh subtractive underexpressed zbtb11 zip14
Tagcloud (Difference) ?		1beta affecting alkaloid anticancer bcl caspases cdk1 compound cytokines cytotoxicity g0 g1 inducing k562 lamd lamellarin leukemia marine p27 panel poorly pronounced smad3 stgc3 survivin tgf thinking understood way	adh1c aldh6a1 aldob apom ces1 fads1 ftl glo1 hemopexin hnrpdl loc644587 lrrc28 methylglyoxal orosomucoid pabpc1 pla2g10 polr2k rpl14 rpl41 rpl8 rps17 rps24 rps5 srp9 ssh subtractive underexpressed zbtb11 zip14
Tagcloud (Intersection) ?