SMAD5 and HOXA13

Number of citations of the paper that reports this interaction (PubMedID 16087734)
77

Data Source:
HPRD (two hybrid)

		SMAD5	HOXA13
Description		SMAD family member 5	homeobox A13
Image
GO Annotations	Cellular Component	Chromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Protein-containing Complex SMAD Protein Complex Heteromeric SMAD Protein Complex	Chromatin Nucleus Nucleoplasm Chromosome Intermediate Filament Cytoskeleton
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding DEAD/H-box RNA Helicase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding I-SMAD Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoblast Differentiation Ureteric Bud Development Mullerian Duct Regression Osteoblast Fate Commitment Cardiac Conduction System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intracellular Iron Ion Homeostasis Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Anatomical Structure Morphogenesis Embryonic Pattern Specification Negative Regulation Of Gene Expression Cell Differentiation Erythrocyte Differentiation BMP Signaling Pathway Developmental Process Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation Cartilage Development Cardiac Muscle Contraction Bone Development SMAD Protein Signal Transduction Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Fas Signaling Pathway Anti-Mullerian Hormone Receptor Signaling Pathway	Skeletal System Development Vasculogenesis Endothelial Cell Morphogenesis Tissue Homeostasis Ventricular Septum Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Animal Organ Morphogenesis Regulation Of BMP Signaling Pathway Male Genitalia Development Prostate Gland Development Response To Testosterone Embryonic Forelimb Morphogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Embryonic Hindgut Morphogenesis Inner Ear Development Artery Morphogenesis Branching Involved In Prostate Gland Morphogenesis Endothelial Cell Fate Specification Mesenchymal Cell Apoptotic Process Mitotic Nuclear Division Positive Regulation Of Mesenchymal Cell Apoptotic Process
Pathways		Signaling by BMP
Drugs
Diseases			Hand-foot-genital syndrome Guttmacher syndrome
GWAS		Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Mean platelet volume ( 32888494) Sleep duration (short sleep) ( 30846698)	Hepatitis B surface antigen seroclearance in chronic hepatitis B infection ( 29975729) Metabolite levels ( 23823483)
Interacting Genes		47 interacting genes: ACVR1 ANKRD13A BCAT1 BMP6 CHMP3 COPS5 CXXC5 EP300 FLNA GDF6 HBG2 HGS HOXA13 HOXD13 MBD1 MEN1 MTMR10 NEDD4 PLEKHO1 PNKP POU6F2 PPIL4 PSMD11 PTPN12 RBM4 ROCK1 RYR2 SF3B1 SF3B3 SFPQ SMAD1 SMAD4 SMURF1 SMURF2 SNRNP70 SNRPA SOX5 SOX7 SUV39H1 SUV39H2 TOB1 U2AF2 UBA1 WBP2 WWP1 ZEB2 ZNF8	6 interacting genes: MEIS1 MEIS2 MEIS3 SMAD1 SMAD2 SMAD5
Entrez ID		4090	3209
HPRD ID		04381	00847
Ensembl ID		ENSG00000113658	ENSG00000106031
Uniprot IDs		Q68DB7 Q99717	P31271 Q6DI00
PDB IDs		6FZS 6TCE	2L7Z
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process BMP Signaling Pathway SMAD Binding Negative Regulation Of RNA Metabolic Process Chromatin Nucleoplasm Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding Nucleic Acid Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process R-SMAD Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway DNA-templated Transcription Response To Growth Factor Epithelial Cell Migration Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription	Embryonic Pattern Specification Pattern Specification Process SMAD Protein Complex Heteromeric SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Homomeric SMAD Protein Complex Positive Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Osteoblast Fate Commitment Animal Organ Development Anatomical Structure Morphogenesis Mesonephric Tubule Development Mesonephric Epithelium Development Transcription Regulator Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Anti-Mullerian Hormone Receptor Signaling Pathway Kidney Epithelium Development Positive Regulation Of RNA Metabolic Process Response To Growth Factor Positive Regulation Of Nucleobase-containing Compound Metabolic Process DEAD/H-box RNA Helicase Binding DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transforming Growth Factor Beta Receptor Signaling Pathway Co-SMAD Binding Sequence-specific DNA Binding Eye Development Primary MiRNA Processing Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Cardiac Conduction System Development Animal Organ Morphogenesis Positive Regulation Of Biosynthetic Process Sensory Organ Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Fate Commitment Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Differentiation Pancreas Development Negative Regulation Of Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Tube Development Epithelium Development
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