SMAD5 and GDF6

Number of citations of the paper that reports this interaction (PubMedID 15246821)
0

Data Source:
HPRD (in vitro)

		SMAD5	GDF6
Description		SMAD family member 5	growth differentiation factor 6
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Protein-containing Complex SMAD Protein Complex Heteromeric SMAD Protein Complex	Extracellular Region Extracellular Space
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding DEAD/H-box RNA Helicase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding I-SMAD Binding Sequence-specific Double-stranded DNA Binding	Cytokine Activity Protein Binding Growth Factor Activity Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoblast Differentiation Ureteric Bud Development Mullerian Duct Regression Osteoblast Fate Commitment Cardiac Conduction System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intracellular Iron Ion Homeostasis Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Anatomical Structure Morphogenesis Embryonic Pattern Specification Negative Regulation Of Gene Expression Cell Differentiation Erythrocyte Differentiation BMP Signaling Pathway Developmental Process Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation Cartilage Development Cardiac Muscle Contraction Bone Development SMAD Protein Signal Transduction Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Fas Signaling Pathway Anti-Mullerian Hormone Receptor Signaling Pathway	Metanephros Development Apoptotic Process Epithelial Cell Migration BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Activin Receptor Signaling Pathway Cell Migration Involved In Metanephros Development Fat Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of P38MAPK Cascade Retinal Cell Apoptotic Process
Pathways		Signaling by BMP
Drugs
Diseases			Anophthalmia and microphthalmia (A/M) Klippel-Feil syndrome(KFS)
GWAS		Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Mean platelet volume ( 32888494) Sleep duration (short sleep) ( 30846698)
Interacting Genes		47 interacting genes: ACVR1 ANKRD13A BCAT1 BMP6 CHMP3 COPS5 CXXC5 EP300 FLNA GDF6 HBG2 HGS HOXA13 HOXD13 MBD1 MEN1 MTMR10 NEDD4 PLEKHO1 PNKP POU6F2 PPIL4 PSMD11 PTPN12 RBM4 ROCK1 RYR2 SF3B1 SF3B3 SFPQ SMAD1 SMAD4 SMURF1 SMURF2 SNRNP70 SNRPA SOX5 SOX7 SUV39H1 SUV39H2 TOB1 U2AF2 UBA1 WBP2 WWP1 ZEB2 ZNF8	5 interacting genes: BMPR1A BMPR1B BMPR2 SMAD1 SMAD5
Entrez ID		4090	392255
HPRD ID		04381	11002
Ensembl ID		ENSG00000113658	ENSG00000156466
Uniprot IDs		Q68DB7 Q99717	A0A0S2A5D6 Q6KF10
PDB IDs		6FZS 6TCE
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process BMP Signaling Pathway SMAD Binding Negative Regulation Of RNA Metabolic Process Chromatin Nucleoplasm Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding Nucleic Acid Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process R-SMAD Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway DNA-templated Transcription Response To Growth Factor Epithelial Cell Migration Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription	Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Osteoblast Differentiation Regulation Of Osteoblast Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Anti-Mullerian Hormone Receptor Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Receptor Activity Cardiac Muscle Tissue Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Transmembrane Receptor Protein Serine/threonine Kinase Activity Pattern Specification Process Cartilage Development Cardiac Conduction System Development Stem Cell Differentiation BMP Binding Striated Muscle Tissue Development Muscle Tissue Development Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Bone Mineralization Osteoblast Fate Commitment Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Positive Regulation Of Cell Differentiation Mullerian Duct Regression Tricuspid Valve Morphogenesis Intracellular Iron Ion Homeostasis Negative Regulation Of Muscle Cell Differentiation Transforming Growth Factor Beta Receptor Activity, Type I Negative Regulation Of Chondrocyte Proliferation Bone Development Regulation Of Cartilage Development Regulation Of Bone Mineralization Endochondral Bone Morphogenesis SMAD Protein Complex HFE-transferrin Receptor Complex Mitral Valve Morphogenesis Heteromeric SMAD Protein Complex DEAD/H-box RNA Helicase Binding Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Developmental Process Reproductive Process Regulation Of Ossification Animal Organ Development Pharyngeal Arch Artery Morphogenesis Anatomical Structure Morphogenesis
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