RYR2 and RYR3

Number of citations of the paper that reports this interaction (PMID 12213830)
7

Data Source:
HPRD (in vivo)

		RYR2	RYR3
Gene Name		ryanodine receptor 2 (cardiac)	ryanodine receptor 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Smooth Endoplasmic Reticulum Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Z Disc Sarcoplasmic Reticulum Membrane Calcium Channel Complex Protein Complex Extracellular Vesicular Exosome	Integral Component Of Membrane Junctional Membrane Complex Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Intracellular Ligand-gated Calcium Channel Activity Ryanodine-sensitive Calcium-release Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-release Channel Activity Enzyme Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Identical Protein Binding Protein Self-association Suramin Binding Ion Channel Binding Calcium-induced Calcium Release Activity	Ryanodine-sensitive Calcium-release Channel Activity Calcium Ion Binding Calmodulin Binding Calcium-release Channel Activity Calcium-induced Calcium Release Activity
	Biological Process	Response To Hypoxia Regulation Of Heart Rate Embryonic Heart Tube Morphogenesis Left Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Hypertrophy Detection Of Calcium Ion Calcium Ion Transport Cellular Calcium Ion Homeostasis Positive Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling BMP Signaling Pathway Response To Caffeine Ion Transmembrane Transport Calcium-mediated Signaling Using Intracellular Calcium Source Response To Muscle Stretch Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Sequestering Of Calcium Ion Cytosolic Calcium Ion Homeostasis Response To Redox State Transmembrane Transport Regulation Of Cardiac Muscle Contraction Cardiac Muscle Contraction Canonical Wnt Signaling Pathway Calcium Ion Transport Into Cytosol Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Transmembrane Transport Cellular Response To Caffeine Cellular Response To Epinephrine Stimulus Establishment Of Protein Localization To Endoplasmic Reticulum Ventricular Cardiac Muscle Cell Action Potential Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity By Adrenergic Receptor Signaling Pathway Involved In Positive Regulation Of Cardiac Muscle Contraction Type B Pancreatic Cell Apoptotic Process Positive Regulation Of The Force Of Heart Contraction Positive Regulation Of Calcium-transporting ATPase Activity	Calcium Ion Transport Striated Muscle Contraction Ion Transmembrane Transport Protein Homotetramerization Negative Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To Magnesium Ion Cellular Response To Caffeine Cellular Response To ATP
Pathways		Ion channel transport Stimuli-sensing channels	Ion channel transport Stimuli-sensing channels
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603) Exercise treadmill test traits ( 17903301) Hypertension ( 17554300) Obesity-related traits ( 23251661) Response to cerivastatin ( 21386754) Response to taxane treatment (docetaxel) ( 23006423)	Carotid atherosclerosis in HIV infection ( 20009918)
Protein-Protein Interactions		14 interactors: AKAP6 ALB CACNA1C CALM1 FKBP1B HOMER1 ITPR1 MDM2 PRKACA PRKAR2A RYR1 RYR3 SMAD5 SRI	3 interactors: FKBP1A HNF1A RYR2
Entrez ID		6262	6263
HPRD ID		01619	01620
Ensembl ID		ENSG00000198626	ENSG00000198838
Uniprot IDs		Q92736	Q15413
PDB IDs			4ERV
Enriched GO Terms of Interacting Partners?		Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Ion Homeostasis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Calcium Ion Transport Homeostatic Process Muscle Contraction Regulation Of Ion Transmembrane Transport Muscle System Process Second-messenger-mediated Signaling Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Organic Substance Chemical Homeostasis Response To Organic Cyclic Compound Regulation Of Ion Transport Cytosolic Calcium Ion Homeostasis Regulation Of Cardiac Muscle Contraction Regulation Of Protein Transport Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Cellular Localization Regulation Of Insulin Secretion Regulation Of Establishment Of Protein Localization Regulation Of Striated Muscle Contraction Cellular Metal Ion Homeostasis Regulation Of Peptide Hormone Secretion Regulation Of Intracellular Transport Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Protein Localization Regulation Of Hormone Secretion Response To Organonitrogen Compound Cellular Chemical Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Transport Calcium Ion Transport Into Cytosol Calcium Ion Homeostasis Energy Reserve Metabolic Process Ion Homeostasis Cytosolic Calcium Ion Transport Activation Of Phospholipase C Activity Cellular Response To Stimulus Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Muscle Contraction	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Caffeine Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Sequestering Of Calcium Ion Ventricular Cardiac Muscle Tissue Morphogenesis Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Muscle Tissue Morphogenesis Tissue Morphogenesis Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Regulation Of Cation Channel Activity Chemical Homeostasis Enzyme Linked Receptor Protein Signaling Pathway Cardiac Ventricle Development Organ Morphogenesis Cardiac Chamber Development Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Response To Alkaloid Left Ventricular Cardiac Muscle Tissue Morphogenesis Renal Glucose Absorption Positive Regulation Of Calcium-transporting ATPase Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity By Adrenergic Receptor Signaling Pathway Involved In Positive Regulation Of Cardiac Muscle Contraction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Response To Purine-containing Compound Cytosolic Calcium Ion Homeostasis Cardiac Muscle Tissue Development Regulation Of Calcium Ion Transport Homeostatic Process Positive Regulation Of Sequestering Of Calcium Ion Type B Pancreatic Cell Apoptotic Process Calcium Ion Transmembrane Transport Muscle Contraction Heart Morphogenesis Negative Regulation Of Protein Phosphatase Type 2B Activity Amyloid Fibril Formation Regulation Of Calcium-transporting ATPase Activity Adrenergic Receptor Signaling Pathway Involved In Heart Process Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Muscle System Process Tissue Development Muscle Organ Development Ion Transport
Tagcloud ?		12kda atlantic bedford biphenyls congener congeners creek dioxin exceed f2 fk506 fkbp12 fundulus generations heritable heteroclitus hydrocarbon killifish nbh ndl pcb pcbs ryanodine ryr1 scorton serca2 thrive vastly	adni aid alzheimer amyloidogenesis av cacna1c calcium cascade channels cohorts considerable datasets emission encode etiology focusing heterogeneity implicating inform initiative load neuroimaging oligogenic pet pib positron subsets tomography validation
Tagcloud (Difference) ?		12kda atlantic bedford biphenyls congener congeners creek dioxin exceed f2 fk506 fkbp12 fundulus generations heritable heteroclitus hydrocarbon killifish nbh ndl pcb pcbs ryanodine ryr1 scorton serca2 thrive vastly	adni aid alzheimer amyloidogenesis av cacna1c calcium cascade channels cohorts considerable datasets emission encode etiology focusing heterogeneity implicating inform initiative load neuroimaging oligogenic pet pib positron subsets tomography validation
Tagcloud (Intersection) ?