RYR2 and CACNA1C

Number of citations of the paper that reports this interaction (PubMedID 11576544)
0

Data Source:
HPRD (in vitro)

		RYR2	CACNA1C
Description		ryanodine receptor 2	calcium voltage-gated channel subunit alpha1 C
Image
GO Annotations	Cellular Component	Smooth Endoplasmic Reticulum Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Sarcomere Z Disc Protein-containing Complex Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma	Nucleoplasm Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Cilium Postsynaptic Density Membrane Z Disc T-tubule Dendrite Monoatomic Ion Channel Complex Sarcolemma Cell Projection Perikaryon Synapse Postsynaptic Membrane Postsynaptic Density Membrane L-type Voltage-gated Calcium Channel Complex
	Molecular Function	Monoatomic Ion Channel Activity Ryanodine-sensitive Calcium-release Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Intracellularly Gated Calcium Channel Activity Enzyme Binding Protein Kinase Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Identical Protein Binding Suramin Binding Transmembrane Transporter Binding Calcium-induced Calcium Release Activity	Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding Calmodulin Binding High Voltage-gated Calcium Channel Activity Metal Ion Binding Alpha-actinin Binding Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential
	Biological Process	Response To Hypoxia Regulation Of Heart Rate Embryonic Heart Tube Morphogenesis Left Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Hypertrophy Detection Of Calcium Ion Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Striated Muscle Contraction Positive Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Muscle Activity Calcium-mediated Signaling Response To Caffeine Monoatomic Ion Transmembrane Transport Response To Muscle Stretch Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Cytosolic Calcium Ion Concentration Establishment Of Localization In Cell Response To Redox State Transmembrane Transport Regulation Of Cardiac Muscle Contraction Cardiac Muscle Contraction Calcium Ion Transport Into Cytosol Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Transmembrane Transport Cellular Response To Caffeine Cellular Response To Epinephrine Stimulus Establishment Of Protein Localization To Endoplasmic Reticulum Ventricular Cardiac Muscle Cell Action Potential Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Type B Pancreatic Cell Apoptotic Process Calcium Ion Transmembrane Import Into Cytosol Positive Regulation Of The Force Of Heart Contraction Regulation Of AV Node Cell Action Potential Regulation Of SA Node Cell Action Potential Regulation Of Atrial Cardiac Muscle Cell Action Potential Regulation Of Ventricular Cardiac Muscle Cell Action Potential	Immune System Development Monoatomic Ion Transport Calcium Ion Transport Muscle Contraction Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Monoatomic Ion Transmembrane Transport Embryonic Forelimb Morphogenesis Camera-type Eye Development Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Muscle Contraction Transmembrane Transport Calcium Ion Transport Into Cytosol Cardiac Conduction Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Calcium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During AV Node Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Heart Rate By Cardiac Conduction Calcium Ion Import Across Plasma Membrane Regulation Of Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential
Pathways		Stimuli-sensing channels Ion homeostasis	Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion Phase 0 - rapid depolarisation Phase 2 - plateau phase
Drugs		Flecainide Tetracaine	Ergocalciferol Enflurane Ranolazine Phenytoin Isradipine Topiramate Ibutilide Diltiazem Amlodipine Nimodipine Nisoldipine Spironolactone Cinnarizine Nicardipine Nicardipine Magnesium sulfate Verapamil Verapamil Levomenthol Ethanol Felodipine Nitrendipine Nitrendipine Miconazole Nifedipine Amiodarone Calcium Mibefradil Dronedarone Clevidipine Nilvadipine Nilvadipine Drotaverine Trimebutine Barnidipine Aranidipine Benidipine Cilnidipine Efonidipine Efonidipine Efonidipine Lacidipine Levamlodipine Manidipine Butamben Isavuconazole Propiverine Bioallethrin Bioallethrin Fish oil
Diseases		Catecholaminergic polymorphic ventricular tachycardia Arrhythmogenic right ventricular cardiomyopathy (ARVC)	Brugada syndrome (BRS) Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603) Bipolar disorder and eating disorder ( 26433762) Cerivastatin-induced rhabdomyolysis ( 21386754) cognitive impairment (MMSE score) in Parkinson’s disease ( 33613413) Exercise treadmill test traits ( 17903301) General risk tolerance (MTAG) ( 30643258) Hippocampal volume ( 31530798) Hypertension ( 17554300) Lipid traits ( 24386095 30576415) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Postoperative stroke after cardiac surgery ( 30678657) PR interval ( 32439900) Response to taxane treatment (docetaxel) ( 23006423) Smoking initiation (ever regular vs never regular) ( 30679032)	Acoustic startle blink response ( 25387708) Adult body size ( 32376654) Adventurousness ( 30643258) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Aortic root size ( 28394258) Appendicular lean mass ( 33097823) Atypical femoral fracture in phosphonate treatment ( 31006051) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 18711365 34002096 33263727 31043756 28072414 20351715) Bipolar disorder or major depressive disorder ( 20351715) Bipolar I disorder ( 31043756) Broad depression or bipolar disorder ( 30626913) Broad depression or schizophrenia ( 30626913) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Exploratory eye movement dysfunction in schizophrenia (cognitive search score) ( 26242244) Fractional exhaled nitric oxide (childhood) ( 24315451) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 28869591 30598549) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Major depressive disorder and major depressive episode treated with electroconvulsive therapy ( 33483693) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Perceived intensity of aspartame ( 31005972) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale) ( 28525603) Red blood cell count ( 27863252 32888494 29403010) Red blood cell traits ( 23222517) Response to olanzapine in schizophrenia ( 29503163) Resting heart rate ( 27798624 29769521) Schizophrenia ( 23974872 25056061 28991256 29483656 21926974 22688191 30285260) Schizophrenia or bipolar disorder ( 24280982) Sensorimotor dexterity ( 31596458) Short-term memory (digit-span task) ( 30741946) Sleep quality ( 23728906) Warfarin maintenance dose ( 18535201)
Interacting Genes		21 interacting genes: AKAP6 ALB CACNA1C CACNA1D FKBP1B HOMER1 HSPB2 ITPR1 JPH3 JPH4 KCNN4 LINC00839 MDM2 PRKACA PRKAR2A PSEN1 RYR1 RYR3 SMAD5 SRI UBE2C	25 interacting genes: ACTN2 ANKRD35 BSG C18orf32 CABP1 CACNB3 COPS5 DNAJA3 EFEMP1 FHL2 GNB1 HDAC4 IFT88 NUP133 PCBD1 PICK1 PPM1A PRKACA RIC3 RIMS1 RYR2 SRI SRRT TNIP2 VCP
Entrez ID		6262	775
HPRD ID		01619	00246
Ensembl ID		ENSG00000198626	ENSG00000151067
Uniprot IDs		Q92736	A0A0A0MR67 A0A0A0MSA1 A0A804HI37 A0A804HIJ8 A0A804HJB6 A0A804HKC4 E9PDI6 F5H522 Q13936 Q59GU3 Q5V9X9
PDB IDs		4JKQ 6Y4O 6Y4P 7KL5 7U9Q 7U9R 7U9T 7U9X 7U9Z 7UA1 7UA3 7UA4 7UA5 7UA9 8UQ2 8UQ3 8UQ4 8UQ5 8UXC 8UXE 8UXF 8UXG 8UXH 8UXI 8UXL 8UXM	1T0J 2BE6 2F3Y 2F3Z 2LQC 3G43 3OXQ 5V2P 5V2Q 6C0A 6DAD 6DAE 6DAF 6U39 6U3A 6U3B 6U3D 7L8V 8EOG 8EOI 8FD7 8FHS 8HLP 8HMA 8HMB 8UKO 8UKP 8WE6 8WE7 8WE8 8WE9 8WEA
Enriched GO Terms of Interacting Partners?		Regulation Of Sequestering Of Calcium Ion Calcium Ion Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Transmembrane Transport Regulation Of Metal Ion Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Calcium Ion Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Calcium-mediated Signaling Regulation Of Monoatomic Ion Transport Metal Ion Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Heart Contraction Calcium Channel Complex Z Disc Sarcoplasmic Reticulum Monoatomic Cation Transport Junctional Sarcoplasmic Reticulum Membrane Regulation Of Blood Circulation Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Cardiac Muscle Contraction Calcium Channel Activity Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport System Process Regulation Of Striated Muscle Contraction Monoatomic Ion Transport Regulation Of Heart Rate Inorganic Ion Transmembrane Transport Muscle Contraction Regulation Of Transport Monoatomic Ion Transmembrane Transport Regulation Of System Process Smooth Endoplasmic Reticulum Regulation Of Muscle System Process Muscle System Process Regulation Of Muscle Contraction Protein Tetramerization Sarcoplasmic Reticulum Membrane Intracellularly Gated Calcium Channel Activity Intracellular Signal Transduction T-tubule Positive Regulation Of Transport Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Intracellular Signaling Cassette Calcium Ion Transport Into Cytosol Regulation Of Protein Transport	Synapse Intracellular Protein Localization Regulation Of Protein Localization Cellular Localization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Channel Activator Activity Z Disc Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Protein Transport Calcium Channel Regulator Activity Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Transport Protein Localization To Membrane Cellular Response To Epinephrine Stimulus Regulation Of Establishment Of Protein Localization Calcium Ion Transport Into Cytosol Intracellular Protein Transport Regulation Of ATP Metabolic Process Response To Epinephrine Positive Regulation Of Transport Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Purine Nucleotide Metabolic Process Response To Heat Regulation Of Biological Quality Protein Domain Specific Binding Positive Regulation Of Protein Export From Nucleus Negative Regulation Of Glycolytic Process Regulation Of Monoatomic Ion Transport Establishment Of Localization In Cell Cell Communication By Electrical Coupling Regulation Of Striated Muscle Contraction Cell Communication Involved In Cardiac Conduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Membrane Potential Regulation Of Heart Rate Regulation Of Post-translational Protein Modification Positive Regulation Of Cation Channel Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Cardiac Muscle Hypertrophy Negative Regulation Of ATP Metabolic Process Protein Kinase A Regulatory Subunit Binding Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cation Transmembrane Transport Regulation Of Intracellular Transport Regulation Of Protein Secretion Regulation Of Cardiac Conduction Calcium Channel Complex Muscle Hypertrophy
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