SMAD5 and BMP6

Number of citations of the paper that reports this interaction (PMID 10504300)
42

Data Source:
HPRD (in vivo)

		SMAD5	BMP6
Gene Name		SMAD family member 5	bone morphogenetic protein 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Integral Component Of Membrane Protein Complex	Extracellular Space Cytoplasm Membrane-bounded Vesicle
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Receptor Signaling Protein Activity Protein Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Ubiquitin Protein Ligase Binding Metal Ion Binding	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Growth Factor Activity Protein Heterodimerization Activity BMP Receptor Binding
	Biological Process	Ureteric Bud Development Mullerian Duct Regression Osteoblast Fate Commitment Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Embryonic Pattern Specification Erythrocyte Differentiation BMP Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Cartilage Development Cardiac Muscle Contraction Bone Development Cellular Response To Organic Cyclic Compound Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus	Skeletal System Development Osteoblast Differentiation Eye Development Kidney Development Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Type B Pancreatic Cell Development Cellular Iron Ion Homeostasis Inflammatory Response Immune Response Response To Iron Ion Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Response To Activity Positive Regulation Of Bone Mineralization BMP Signaling Pathway Male Genitalia Development Response To Magnesium Ion Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Aldosterone Biosynthetic Process Response To Retinoic Acid Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Cartilage Development Response To Glucocorticoid SMAD Protein Signal Transduction Cellular Response To Mechanical Stimulus Positive Regulation Of DNA-dependent DNA Replication Positive Regulation Of Aldosterone Secretion
Pathways		Signaling by BMP
Drugs
Diseases
GWAS			Height ( 20881960 23563607 18391951) Myopia (pathological) ( 23049088) Orofacial clefts ( 22419666)
Protein-Protein Interactions		44 interactors: ACVR1 ANKRD13A BCAT1 BMP6 CHMP3 COPS5 CXXC5 EP300 FLNA GDF6 HBG2 HGS HOXA13 HOXD13 MBD1 MEN1 MTMR10 NEDD4 PLEKHO1 PNKP PPIL4 PSMD11 PTPN12 RBM4 RYR2 SF3B1 SF3B3 SFPQ SMAD1 SMAD4 SMURF1 SMURF2 SNRNP70 SNRPA SOX5 SOX7 SUV39H1 SUV39H2 TOB1 U2AF2 UBA1 WWP1 ZEB2 ZNF8	9 interactors: ACVR2A BMPER BMPR1A BMPR1B BMPR2 CHRDL2 NCOA3 SMAD5 SOSTDC1
Entrez ID		4090	654
HPRD ID		04381	00211
Ensembl ID		ENSG00000113658	ENSG00000153162
Uniprot IDs		Q68DB7 Q99717	B4DUF7 P22004 Q4VBA3
PDB IDs			2QCW 2R52 2R53
Enriched GO Terms of Interacting Partners?		BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Gene Expression Positive Regulation Of Gene Expression RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Transforming Growth Factor Beta RNA Biosynthetic Process Regulation Of Signal Transduction Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Signal Transduction Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Tissue Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Ossification Embryonic Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation	Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Regulation Of BMP Signaling Pathway Tissue Development Positive Regulation Of Ossification Regulation Of Osteoblast Differentiation Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cartilage Development Regulation Of Ossification Pattern Specification Process Organ Development Regulation Of Bone Mineralization Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Skeletal System Development Sex Differentiation Tube Development Anatomical Structure Morphogenesis Negative Regulation Of Chondrocyte Proliferation Positive Regulation Of Cell Differentiation System Development Regulation Of Cell Differentiation Regulation Of Signal Transduction Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Multicellular Organismal Development Epithelium Development Regulation Of Signaling Anatomical Structure Development Mullerian Duct Regression Developmental Process Signal Transduction By Phosphorylation Developmental Process Involved In Reproduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Organ Morphogenesis Anatomical Structure Regression Mesoderm Development Embryo Development Cellular Response To BMP Stimulus Single Organism Reproductive Process Male Sex Differentiation Gastrulation Positive Regulation Of Signal Transduction Limb Development Reproductive Process Protein Phosphorylation
Tagcloud ?		1beta affecting alkaloid anticancer bcl caspases cdk1 compound cytokines cytotoxicity g0 g1 inducing k562 lamd lamellarin leukemia marine p27 panel poorly pronounced smad3 stgc3 survivin tgf thinking understood way	anpep bmp2 bsp col il10 il6 itga6 ligament mcam mineralized mitf mmp2 msc mscs ocn orthodontic pdl predictability predictable premolar premolars prom1 regenerative rpl13a runt runx2 sialoprotein sox9 stemness
Tagcloud (Difference) ?		1beta affecting alkaloid anticancer bcl caspases cdk1 compound cytokines cytotoxicity g0 g1 inducing k562 lamd lamellarin leukemia marine p27 panel poorly pronounced smad3 stgc3 survivin tgf thinking understood way	anpep bmp2 bsp col il10 il6 itga6 ligament mcam mineralized mitf mmp2 msc mscs ocn orthodontic pdl predictability predictable premolar premolars prom1 regenerative rpl13a runt runx2 sialoprotein sox9 stemness
Tagcloud (Intersection) ?