RYR2 and HOMER1

Number of citations of the paper that reports this interaction (PMID 12887973)
12

Data Source:
HPRD (in vivo, in vitro)

		RYR2	HOMER1
Gene Name		ryanodine receptor 2 (cardiac)	homer homolog 1 (Drosophila)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Smooth Endoplasmic Reticulum Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Z Disc Sarcoplasmic Reticulum Membrane Calcium Channel Complex Protein Complex Extracellular Vesicular Exosome	Z Disc Cell Junction Axon Neuronal Cell Body Costamere Dendritic Shaft Apical Part Of Cell Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density
	Molecular Function	Intracellular Ligand-gated Calcium Channel Activity Ryanodine-sensitive Calcium-release Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-release Channel Activity Enzyme Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Identical Protein Binding Protein Self-association Suramin Binding Ion Channel Binding Calcium-induced Calcium Release Activity	Type 5 Metabotropic Glutamate Receptor Binding Protein Complex Scaffold G-protein Coupled Glutamate Receptor Binding Signaling Adaptor Activity Identical Protein Binding Ion Channel Binding Protein Heterodimerization Activity Scaffold Protein Binding
	Biological Process	Response To Hypoxia Regulation Of Heart Rate Embryonic Heart Tube Morphogenesis Left Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Hypertrophy Detection Of Calcium Ion Calcium Ion Transport Cellular Calcium Ion Homeostasis Positive Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling BMP Signaling Pathway Response To Caffeine Ion Transmembrane Transport Calcium-mediated Signaling Using Intracellular Calcium Source Response To Muscle Stretch Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Sequestering Of Calcium Ion Cytosolic Calcium Ion Homeostasis Response To Redox State Transmembrane Transport Regulation Of Cardiac Muscle Contraction Cardiac Muscle Contraction Canonical Wnt Signaling Pathway Calcium Ion Transport Into Cytosol Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Transmembrane Transport Cellular Response To Caffeine Cellular Response To Epinephrine Stimulus Establishment Of Protein Localization To Endoplasmic Reticulum Ventricular Cardiac Muscle Cell Action Potential Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity By Adrenergic Receptor Signaling Pathway Involved In Positive Regulation Of Cardiac Muscle Contraction Type B Pancreatic Cell Apoptotic Process Positive Regulation Of The Force Of Heart Contraction Positive Regulation Of Calcium-transporting ATPase Activity	Skeletal Muscle Contraction Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Circadian Rhythm Positive Regulation Of Signal Transduction Response To Nicotine Protein Localization To Synapse Behavioral Response To Cocaine Skeletal Muscle Fiber Development Chemical Homeostasis Within A Tissue Response To Calcium Ion Positive Regulation Of Calcium Ion Transport Regulation Of Calcium Ion Import Regulation Of Store-operated Calcium Entry Regulation Of Cation Channel Activity
Pathways		Ion channel transport Stimuli-sensing channels
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603) Exercise treadmill test traits ( 17903301) Hypertension ( 17554300) Obesity-related traits ( 23251661) Response to cerivastatin ( 21386754) Response to taxane treatment (docetaxel) ( 23006423)	Height ( 18193045) Major depressive disorder ( 20673876)
Protein-Protein Interactions		14 interactors: AKAP6 ALB CACNA1C CALM1 FKBP1B HOMER1 ITPR1 MDM2 PRKACA PRKAR2A RYR1 RYR3 SMAD5 SRI	19 interactors: ABI3 AGAP2 C19orf57 C1orf116 DNM3 EFNB2 FAT1 GRIA1 GRIK1 GRM1 GRM5 HOMER3 ITPR1 RYR1 RYR2 SHANK1 STX12 TANC1 TRPC1
Entrez ID		6262	9456
HPRD ID		01619	09211
Ensembl ID		ENSG00000198626
Uniprot IDs		Q92736	Q5U5K4 Q86YM7
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Ion Homeostasis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Calcium Ion Transport Homeostatic Process Muscle Contraction Regulation Of Ion Transmembrane Transport Muscle System Process Second-messenger-mediated Signaling Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Organic Substance Chemical Homeostasis Response To Organic Cyclic Compound Regulation Of Ion Transport Cytosolic Calcium Ion Homeostasis Regulation Of Cardiac Muscle Contraction Regulation Of Protein Transport Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Cellular Localization Regulation Of Insulin Secretion Regulation Of Establishment Of Protein Localization Regulation Of Striated Muscle Contraction Cellular Metal Ion Homeostasis Regulation Of Peptide Hormone Secretion Regulation Of Intracellular Transport Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Protein Localization Regulation Of Hormone Secretion Response To Organonitrogen Compound Cellular Chemical Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Transport Calcium Ion Transport Into Cytosol Calcium Ion Homeostasis Energy Reserve Metabolic Process Ion Homeostasis Cytosolic Calcium Ion Transport Activation Of Phospholipase C Activity Cellular Response To Stimulus Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Muscle Contraction	Glutamate Receptor Signaling Pathway Cell-cell Signaling Cytosolic Calcium Ion Homeostasis G-protein Coupled Glutamate Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol Calcium Ion Homeostasis Regulation Of Sequestering Of Calcium Ion Behavior Regulation Of Ion Transport Calcium Ion Transport Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Transport Regulation Of Ion Homeostasis Cellular Metal Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Synaptic Transmission, Glutamatergic Cellular Cation Homeostasis Calcium Ion Transmembrane Transport Cellular Ion Homeostasis Single-organism Behavior Metal Ion Homeostasis Developmental Process Sarcoplasmic Reticulum Calcium Ion Transport Cellular Response To Caffeine Cellular Chemical Homeostasis Learning Or Memory Ion Homeostasis Cognition Synaptic Transmission Regulation Of Synaptic Transmission Calcium Ion Transport Dendritic Spine Organization Cellular Homeostasis Learning Cell Projection Organization Response To Caffeine Multicellular Organismal Development Anatomical Structure Morphogenesis Ion Transmembrane Transport Anatomical Structure Development Chemical Homeostasis Regulation Of Calcium Ion Transport Ionotropic Glutamate Receptor Signaling Pathway Cellular Response To Alkaloid Positive Regulation Of Ion Transport Synaptic Transmission, Glutamatergic Long-term Memory Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Determination Of Affect
Tagcloud ?		12kda atlantic bedford biphenyls congener congeners creek dioxin exceed f2 fk506 fkbp12 fundulus generations heritable heteroclitus hydrocarbon killifish nbh ndl pcb pcbs ryanodine ryr1 scorton serca2 thrive vastly	accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 kat2b kat3a kat3b kat5 multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1
Tagcloud (Difference) ?		12kda atlantic bedford biphenyls congener congeners creek dioxin exceed f2 fk506 fkbp12 fundulus generations heritable heteroclitus hydrocarbon killifish nbh ndl pcb pcbs ryanodine ryr1 scorton serca2 thrive vastly	accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 kat2b kat3a kat3b kat5 multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1
Tagcloud (Intersection) ?