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RPA2 and XPA
Number of citations of the paper that reports this interaction (PubMedID
11081631
)
0
Data Source:
HPRD
(in vitro)
RPA2
XPA
Description
replication protein A2
XPA, DNA damage recognition and repair factor
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Nuclear Body
PML Body
Site Of Double-strand Break
Nucleotide-excision Repair Factor 1 Complex
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Cytosol
Nuclear Body
Molecular Function
DNA Binding
Damaged DNA Binding
Single-stranded DNA Binding
Protein Binding
Enzyme Binding
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
Telomeric DNA Binding
G-rich Strand Telomeric DNA Binding
DNA Binding
Damaged DNA Binding
Protein Binding
Zinc Ion Binding
Protein Domain Specific Binding
Protein Homodimerization Activity
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
DNA Damage Checkpoint Signaling
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Replication
DNA Repair
Base-excision Repair
Nucleotide-excision Repair
Mismatch Repair
DNA Recombination
DNA Damage Response
Regulation Of Double-strand Break Repair Via Homologous Recombination
Mitotic G1 DNA Damage Checkpoint Signaling
Protein Localization To Chromosome
Regulation Of DNA Damage Checkpoint
Nucleotide-excision Repair, DNA Damage Recognition
DNA Repair
Base-excision Repair
Nucleotide-excision Repair
DNA Damage Response
Response To Oxidative Stress
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To UV
Response To Toxic Substance
UV Protection
Regulation Of Autophagy
Protein Localization To Nucleus
Multicellular Organism Growth
Positive Regulation Of Transcription Initiation By RNA Polymerase II
UV-damage Excision Repair
Nucleotide-excision Repair Involved In Interstrand Cross-link Repair
Pathways
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Removal of the Flap Intermediate from the C-strand
Activation of ATR in response to replication stress
Regulation of HSF1-mediated heat shock response
HSF1 activation
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
Activation of the pre-replicative complex
Removal of the Flap Intermediate
G2/M DNA damage checkpoint
Meiotic recombination
Impaired BRCA2 binding to RAD51
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Drugs
Diseases
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS
HDL cholesterol levels (
32203549
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
White blood cell count (
32888494
)
Hypothyroidism (
27182965
)
Obesity-related traits (
23251661
)
Serum thyroid-stimulating hormone levels (
24852370
)
Thyroid cancer (Papillary, radiation-related) (
20350937
)
Interacting Genes
69 interacting genes:
ACP5
AKAP9
APP
ATM
CALCOCO2
CASK
CCNC
CCNO
CDK1
CEBPA
CEP126
CFB
COPS6
CRMP1
DMRTB1
EEF1A1
ERCC1
ERCC4
EXOSC7
GAPDH
GOLM1
HERPUD1
HIRA
HNRNPUL1
HUS1
LNX2
LRIF1
MARK2
MCM2
MCM5
MED31
MEN1
NDEL1
ORC1
ORC2
ORC5
PCM1
PIAS1
PIAS4
PRC1
PRKDC
RAD1
RAD51
RAD52
RAD9A
RBM14
RBM48
RNF20
RNF40
RPA1
RPA3
RPLP1
SDF4
SERTAD3
SF1
SLC17A9
SMARCAL1
STAT3
TLE1
TP53
TUBB2A
UNC119
UNG
UTP14A
WAS
WRN
XPA
YWHAE
ZBTB14
51 interacting genes:
ARID3A
ATM
ATR
AURKA
BMPR1A
BUB1
CEP164
DDB1
DDB2
DLC1
DVL3
ERCC1
ERCC6
FBXW7
GPN1
GTF2E2
GTF2H1
HERC2
MEOX2
MLH1
MLH3
MSH2
MSH3
MUTYH
NDEL1
NRAS
PCNA
PDGFRL
PICK1
PMS2
POLR1C
PRDM16
PRKDC
PSMB1
RASSF1
RB1
RHOU
RPA1
RPA2
RPA4
SKIL
SMAD2
SNPH
SRC
STK11
TBC1D7
TRIM27
VPS26C
XAB2
XPC
ZNF655
Entrez ID
6118
7507
HPRD ID
01566
02045
Ensembl ID
ENSG00000117748
ENSG00000136936
Uniprot IDs
B4DUL2
P15927
P23025
PDB IDs
1DPU
1L1O
1QUQ
1Z1D
2PI2
2PQA
2Z6K
3KDF
4MQV
4OU0
8RK2
9MJ5
1D4U
1XPA
2JNW
6J44
6LAE
6RO4
7AD8
8EBT
8EBU
8EBX
8EBY
Enriched GO Terms of Interacting Partners
?
DNA Metabolic Process
DNA Repair
Chromosome, Telomeric Region
Double-strand Break Repair
Nucleic Acid Metabolic Process
Nucleobase-containing Compound Metabolic Process
Nucleoplasm
DNA Damage Response
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
DNA Recombination
Macromolecule Metabolic Process
Response To Radiation
Nucleus
Telomere Maintenance
Response To Ionizing Radiation
Cellular Response To Stress
Cellular Response To Radiation
Nucleotide-excision Repair
Telomere Organization
DNA Replication Origin Binding
Site Of Double-strand Break
DNA Replication
Regulation Of DNA Metabolic Process
Damaged DNA Binding
Chromosome Organization
Single-stranded DNA Binding
Mitotic DNA Integrity Checkpoint Signaling
Nuclear Origin Of Replication Recognition Complex
Cellular Response To Ionizing Radiation
Regulation Of Cell Cycle
Response To Light Stimulus
Nucleotide-excision Repair Factor 1 Complex
Response To Gamma Radiation
DNA Replication Initiation
Response To Stress
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
UV Protection
Negative Regulation Of Cell Cycle
DNA Damage Checkpoint Signaling
DNA Replication Factor A Complex
Regulation Of Cellular Response To Stress
Response To UV
PML Body
Replicative Senescence
Mitotic DNA Damage Checkpoint Signaling
Base-excision Repair
Checkpoint Clamp Complex
Regulation Of Macromolecule Metabolic Process
DNA Damage Response
DNA Repair
Mismatch Repair
DNA Metabolic Process
Cellular Response To Stress
Nucleotide-excision Repair
Chromosome Organization
Nucleoplasm
Nucleic Acid Metabolic Process
Regulation Of Cell Cycle Phase Transition
ATP-dependent DNA Damage Sensor Activity
Damaged DNA Binding
Response To UV
Single-stranded DNA Binding
Response To Stress
Negative Regulation Of Cell Cycle Phase Transition
Somatic Cell DNA Recombination
Mismatched DNA Binding
DNA Recombination
Chromosome, Telomeric Region
Nucleus
DNA Binding
Cellular Response To UV
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Cell Cycle Process
DNA Damage Checkpoint Signaling
Somatic Recombination Of Immunoglobulin Gene Segments
Double-strand Break Repair
Cellular Response To Light Stimulus
Cellular Response To Radiation
Regulation Of Cell Cycle Process
MutSalpha Complex Binding
MutLalpha Complex Binding
Somatic Diversification Of Immunoglobulins
Response To Radiation
Negative Regulation Of Cell Cycle
Negative Regulation Of DNA Metabolic Process
Regulation Of Cell Cycle
Pyrimidine Dimer Repair
Negative Regulation Of Mitotic Cell Cycle
Signal Transduction In Response To DNA Damage
Regulation Of DNA Metabolic Process
Telomere Maintenance
UV-damage Excision Repair
Histone H2AXS139 Kinase Activity
Dinucleotide Insertion Or Deletion Binding
Regulation Of Mitotic Cell Cycle
Protein Localization To Chromosome
Response To Light Stimulus
Regulation Of Mitotic Cell Cycle Phase Transition
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Tagcloud (Difference)
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Tagcloud (Intersection)
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