RPA2 and SMARCAL1

Number of citations of the paper that reports this interaction (PubMedID 37827155)
181

Data Source:
BioGRID (pull down, x-ray crystallography, proximity labelling technology)

		RPA2	SMARCAL1
Description		replication protein A2	SNF2 related chromatin remodeling annealing helicase 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm DNA Replication Factor A Complex Nuclear Body PML Body Site Of Double-strand Break	Nucleus Nucleoplasm DNA Replication Factor A Complex Site Of Double-strand Break Nuclear Replication Fork
	Molecular Function	DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Telomeric DNA Binding G-rich Strand Telomeric DNA Binding	Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity ATP-dependent DNA/DNA Annealing Activity
	Biological Process	DNA Damage Checkpoint Signaling Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Base-excision Repair Nucleotide-excision Repair Mismatch Repair DNA Recombination DNA Damage Response Regulation Of Double-strand Break Repair Via Homologous Recombination Mitotic G1 DNA Damage Checkpoint Signaling Protein Localization To Chromosome Regulation Of DNA Damage Checkpoint	DNA Repair Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Transcription By RNA Polymerase II DNA Damage Response Replication Fork Processing T-circle Formation
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Removal of the Flap Intermediate from the C-strand Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HSF1 activation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Activation of the pre-replicative complex Removal of the Flap Intermediate G2/M DNA damage checkpoint Meiotic recombination Impaired BRCA2 binding to RAD51
Drugs
Diseases			Schimke immunoosseous dysplasia
GWAS		HDL cholesterol levels ( 32203549) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness ( 32963231) Cortical thickness (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter integrity (fractional anisotropy) ( 32358547)
Interacting Genes		69 interacting genes: ACP5 AKAP9 APP ATM CALCOCO2 CASK CCNC CCNO CDK1 CEBPA CEP126 CFB COPS6 CRMP1 DMRTB1 EEF1A1 ERCC1 ERCC4 EXOSC7 GAPDH GOLM1 HERPUD1 HIRA HNRNPUL1 HUS1 LNX2 LRIF1 MARK2 MCM2 MCM5 MED31 MEN1 NDEL1 ORC1 ORC2 ORC5 PCM1 PIAS1 PIAS4 PRC1 PRKDC RAD1 RAD51 RAD52 RAD9A RBM14 RBM48 RNF20 RNF40 RPA1 RPA3 RPLP1 SDF4 SERTAD3 SF1 SLC17A9 SMARCAL1 STAT3 TLE1 TP53 TUBB2A UNC119 UNG UTP14A WAS WRN XPA YWHAE ZBTB14	1 interacting genes: RPA2
Entrez ID		6118	50485
HPRD ID		01566	05969
Ensembl ID		ENSG00000117748	ENSG00000138375
Uniprot IDs		B4DUL2 P15927	Q9NZC9
PDB IDs		1DPU 1L1O 1QUQ 1Z1D 2PI2 2PQA 2Z6K 3KDF 4MQV 4OU0 8RK2 9MJ5	4MQV
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Repair Chromosome, Telomeric Region Double-strand Break Repair Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoplasm DNA Damage Response Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Recombination Macromolecule Metabolic Process Response To Radiation Nucleus Telomere Maintenance Response To Ionizing Radiation Cellular Response To Stress Cellular Response To Radiation Nucleotide-excision Repair Telomere Organization DNA Replication Origin Binding Site Of Double-strand Break DNA Replication Regulation Of DNA Metabolic Process Damaged DNA Binding Chromosome Organization Single-stranded DNA Binding Mitotic DNA Integrity Checkpoint Signaling Nuclear Origin Of Replication Recognition Complex Cellular Response To Ionizing Radiation Regulation Of Cell Cycle Response To Light Stimulus Nucleotide-excision Repair Factor 1 Complex Response To Gamma Radiation DNA Replication Initiation Response To Stress Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process UV Protection Negative Regulation Of Cell Cycle DNA Damage Checkpoint Signaling DNA Replication Factor A Complex Regulation Of Cellular Response To Stress Response To UV PML Body Replicative Senescence Mitotic DNA Damage Checkpoint Signaling Base-excision Repair Checkpoint Clamp Complex Regulation Of Macromolecule Metabolic Process	Positive Regulation Of Phosphatidylcholine Biosynthetic Process Medium-chain Fatty Acid-CoA Ligase Activity Regulation Of Phosphatidylcholine Metabolic Process Positive Regulation Of Golgi To Plasma Membrane Protein Transport Very-low-density Lipoprotein Particle Assembly Arachidonate-CoA Ligase Activity Regulation Of Golgi To Plasma Membrane Protein Transport Regulation Of Phosphatidylcholine Biosynthetic Process Long-chain Fatty Acid Import Into Cell Palmitoyl-CoA Ligase Activity Positive Regulation Of Phospholipid Biosynthetic Process Fatty Acid-CoA Ligase Activity G-rich Strand Telomeric DNA Binding Long-chain Fatty Acid-CoA Ligase Activity Lipid Import Into Cell DNA Replication Factor A Complex Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling Regulation Of Phospholipid Biosynthetic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Plasma Lipoprotein Particle Assembly Regulation Of DNA Damage Checkpoint Protein-lipid Complex Assembly Long-chain Fatty-acyl-CoA Metabolic Process Fatty-acyl-CoA Biosynthetic Process Telomeric DNA Binding Mismatch Repair Regulation Of Phospholipid Metabolic Process Base-excision Repair Fatty Acid Derivative Biosynthetic Process Long-chain Fatty Acid Transport Nucleotide-excision Repair Peroxisomal Membrane Positive Regulation Of Protein Localization To Plasma Membrane Damaged DNA Binding Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Positive Regulation Of Protein Localization To Cell Periphery Fatty Acid Derivative Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Sulfur Compound Biosynthetic Process Lipid Droplet Long-chain Fatty Acid Metabolic Process Fatty Acid Transport Acyl-CoA Metabolic Process Positive Regulation Of Protein Localization To Membrane Telomere Maintenance Protein Phosphatase Binding
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