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RPA2 and RAD9A
Number of citations of the paper that reports this interaction (PubMedID
15897895
)
50
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
RPA2
RAD9A
Description
replication protein A2
RAD9 checkpoint clamp component A
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Nuclear Body
PML Body
Site Of Double-strand Break
Nucleus
Nucleoplasm
Cytoplasm
Checkpoint Clamp Complex
Molecular Function
DNA Binding
Damaged DNA Binding
Single-stranded DNA Binding
Protein Binding
Enzyme Binding
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
Telomeric DNA Binding
G-rich Strand Telomeric DNA Binding
Nuclease Activity
Exonuclease Activity
Protein Binding
Double-stranded DNA 3'-5' DNA Exonuclease Activity
3'-5' Exonuclease Activity
Hydrolase Activity
SH3 Domain Binding
Enzyme Binding
Protein Kinase Binding
Histone Deacetylase Binding
Biological Process
DNA Damage Checkpoint Signaling
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Replication
DNA Repair
Base-excision Repair
Nucleotide-excision Repair
Mismatch Repair
DNA Recombination
DNA Damage Response
Regulation Of Double-strand Break Repair Via Homologous Recombination
Mitotic G1 DNA Damage Checkpoint Signaling
Protein Localization To Chromosome
Regulation Of DNA Damage Checkpoint
DNA Replication Checkpoint Signaling
DNA Damage Checkpoint Signaling
DNA Repair
DNA Damage Response
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Mitotic Intra-S DNA Damage Checkpoint Signaling
Cellular Response To Ionizing Radiation
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Removal of the Flap Intermediate from the C-strand
Activation of ATR in response to replication stress
Regulation of HSF1-mediated heat shock response
HSF1 activation
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
Activation of the pre-replicative complex
Removal of the Flap Intermediate
G2/M DNA damage checkpoint
Meiotic recombination
Impaired BRCA2 binding to RAD51
Activation of ATR in response to replication stress
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS
HDL cholesterol levels (
32203549
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
White blood cell count (
32888494
)
Body fat distribution (arm fat ratio) (
30664634
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Interacting Genes
69 interacting genes:
ACP5
AKAP9
APP
ATM
CALCOCO2
CASK
CCNC
CCNO
CDK1
CEBPA
CEP126
CFB
COPS6
CRMP1
DMRTB1
EEF1A1
ERCC1
ERCC4
EXOSC7
GAPDH
GOLM1
HERPUD1
HIRA
HNRNPUL1
HUS1
LNX2
LRIF1
MARK2
MCM2
MCM5
MED31
MEN1
NDEL1
ORC1
ORC2
ORC5
PCM1
PIAS1
PIAS4
PRC1
PRKDC
RAD1
RAD51
RAD52
RAD9A
RBM14
RBM48
RNF20
RNF40
RPA1
RPA3
RPLP1
SDF4
SERTAD3
SF1
SLC17A9
SMARCAL1
STAT3
TLE1
TP53
TUBB2A
UNC119
UNG
UTP14A
WAS
WRN
XPA
YWHAE
ZBTB14
39 interacting genes:
ABL1
AR
ATAD5
ATM
BCL2
BCL2L1
CAD
CDK1
CHEK2
CLSPN
COPS5
CSNK2A1
CSNK2A2
DNAJC7
FEM1B
FEN1
HDAC1
HUS1
HUS1B
ITSN2
MLH1
MSH2
MSH3
MSH6
NR3C1
OGG1
PCNA
POLB
PRKCE
RAD17
RAD9B
RHNO1
RPA1
RPA2
SF3B3
TDG
TLK1
TOPBP1
WRN
Entrez ID
6118
5883
HPRD ID
01566
04788
Ensembl ID
ENSG00000117748
ENSG00000172613
Uniprot IDs
B4DUL2
P15927
Q99638
PDB IDs
1DPU
1L1O
1QUQ
1Z1D
2PI2
2PQA
2Z6K
3KDF
4MQV
4OU0
8RK2
9MJ5
3A1J
3G65
3GGR
6HM5
6J8Y
7Z6H
8GNN
8JZY
8WU8
Enriched GO Terms of Interacting Partners
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DNA Metabolic Process
DNA Repair
Chromosome, Telomeric Region
Double-strand Break Repair
Nucleic Acid Metabolic Process
Nucleobase-containing Compound Metabolic Process
Nucleoplasm
DNA Damage Response
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
DNA Recombination
Macromolecule Metabolic Process
Response To Radiation
Nucleus
Telomere Maintenance
Response To Ionizing Radiation
Cellular Response To Stress
Cellular Response To Radiation
Nucleotide-excision Repair
Telomere Organization
DNA Replication Origin Binding
Site Of Double-strand Break
DNA Replication
Regulation Of DNA Metabolic Process
Damaged DNA Binding
Chromosome Organization
Single-stranded DNA Binding
Mitotic DNA Integrity Checkpoint Signaling
Nuclear Origin Of Replication Recognition Complex
Cellular Response To Ionizing Radiation
Regulation Of Cell Cycle
Response To Light Stimulus
Nucleotide-excision Repair Factor 1 Complex
Response To Gamma Radiation
DNA Replication Initiation
Response To Stress
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
UV Protection
Negative Regulation Of Cell Cycle
DNA Damage Checkpoint Signaling
DNA Replication Factor A Complex
Regulation Of Cellular Response To Stress
Response To UV
PML Body
Replicative Senescence
Mitotic DNA Damage Checkpoint Signaling
Base-excision Repair
Checkpoint Clamp Complex
Regulation Of Macromolecule Metabolic Process
DNA Damage Response
DNA Repair
DNA Metabolic Process
Cellular Response To Stress
Signal Transduction In Response To DNA Damage
DNA Damage Checkpoint Signaling
DNA Recombination
Double-strand Break Repair
Mitotic DNA Damage Checkpoint Signaling
Nucleic Acid Metabolic Process
Mitotic DNA Integrity Checkpoint Signaling
Mismatch Repair
Response To Stress
Regulation Of Cell Cycle Process
Regulation Of Cell Cycle
Negative Regulation Of Cell Cycle Phase Transition
Nucleobase-containing Compound Metabolic Process
Chromosome Organization
Negative Regulation Of Cell Cycle
Negative Regulation Of Cell Cycle Process
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Phase Transition
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Macromolecule Metabolic Process
Nucleoplasm
Intracellular Signal Transduction
Response To Ionizing Radiation
Response To Radiation
Damaged DNA Binding
Nucleus
Regulation Of DNA Metabolic Process
Protein Localization To Site Of Double-strand Break
Recombinational Repair
Mitotic Intra-S DNA Damage Checkpoint Signaling
Base-excision Repair
Enzyme Binding
Regulation Of Mitotic Cell Cycle
DNA Replication Checkpoint Signaling
Intrinsic Apoptotic Signaling Pathway
Regulation Of Cellular Response To Stress
Chromosome, Telomeric Region
Somatic Cell DNA Recombination
Mitotic DNA Replication Checkpoint Signaling
Negative Regulation Of DNA Metabolic Process
Double-strand Break Repair Via Homologous Recombination
Negative Regulation Of DNA Recombination
Mismatched DNA Binding
Regulation Of DNA Recombination
Guanine/thymine Mispair Binding
Mitotic G2/M Transition Checkpoint
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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