RPA2 and CFB

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RPA2	CFB
Description		replication protein A2	complement factor B
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm DNA Replication Factor A Complex Nuclear Body PML Body Site Of Double-strand Break	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Extracellular Exosome Blood Microparticle Symbiont Cell Surface
	Molecular Function	DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Telomeric DNA Binding G-rich Strand Telomeric DNA Binding	Complement Binding Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	DNA Damage Checkpoint Signaling Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Base-excision Repair Nucleotide-excision Repair Mismatch Repair DNA Recombination DNA Damage Response Regulation Of Double-strand Break Repair Via Homologous Recombination Mitotic G1 DNA Damage Checkpoint Signaling Protein Localization To Chromosome Regulation Of DNA Damage Checkpoint	Activation Of Membrane Attack Complex Pre-B Cell Differentiation Immune System Process Proteolysis Complement Activation Complement Activation, Alternative Pathway Response To Bacterium Killing Of Cells Of Another Organism Innate Immune Response Protein Maturation
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Removal of the Flap Intermediate from the C-strand Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HSF1 activation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Activation of the pre-replicative complex Removal of the Flap Intermediate G2/M DNA damage checkpoint Meiotic recombination Impaired BRCA2 binding to RAD51	Alternative complement activation Activation of C3 and C5 Regulation of Complement cascade
Drugs			Zinc 4-guanidinobenzoic acid Diisopropylphosphono Group MLN2222 Zinc acetate
Diseases			Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency
GWAS		HDL cholesterol levels ( 32203549) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)	A body shape index ( 34021172) Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385826 23577725 23455636 20385819 22694956 21665990) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (geographic atrophy) ( 22705344) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Chronic hepatitis B infection ( 25802187) Coronary artery disease ( 29212778) Disease progression in age-related macular degeneration ( 29346644) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Hematology traits ( 23263863) Inflammatory bowel disease ( 28067908) Neutrophil percentage of white cells ( 32888494) Prostate cancer ( 23535732) Rosacea symptom severity ( 29771307) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908 24837172)
Interacting Genes		69 interacting genes: ACP5 AKAP9 APP ATM CALCOCO2 CASK CCNC CCNO CDK1 CEBPA CEP126 CFB COPS6 CRMP1 DMRTB1 EEF1A1 ERCC1 ERCC4 EXOSC7 GAPDH GOLM1 HERPUD1 HIRA HNRNPUL1 HUS1 LNX2 LRIF1 MARK2 MCM2 MCM5 MED31 MEN1 NDEL1 ORC1 ORC2 ORC5 PCM1 PIAS1 PIAS4 PRC1 PRKDC RAD1 RAD51 RAD52 RAD9A RBM14 RBM48 RNF20 RNF40 RPA1 RPA3 RPLP1 SDF4 SERTAD3 SF1 SLC17A9 SMARCAL1 STAT3 TLE1 TP53 TUBB2A UNC119 UNG UTP14A WAS WRN XPA YWHAE ZBTB14	6 interacting genes: C3 CFP HSP90AA1 LAMC3 LAMTOR5 RPA2
Entrez ID		6118	629
HPRD ID		01566	00718
Ensembl ID		ENSG00000117748	ENSG00000243649
Uniprot IDs		B4DUL2 P15927	A0A1U9X7H8 P00751
PDB IDs		1DPU 1L1O 1QUQ 1Z1D 2PI2 2PQA 2Z6K 3KDF 4MQV 4OU0 8RK2 9MJ5	1DLE 1Q0P 1RRK 1RS0 1RTK 2OK5 2WIN 2XWB 2XWJ 3HRZ 3HS0 6QSW 6QSX 6RAV 6RUR 6RUV 6T8U 6T8V 6T8W 7JTN 7JTQ 7NOZ 8ENU 8EOK 8UIN
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Repair Chromosome, Telomeric Region Double-strand Break Repair Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoplasm DNA Damage Response Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Recombination Macromolecule Metabolic Process Response To Radiation Nucleus Telomere Maintenance Response To Ionizing Radiation Cellular Response To Stress Cellular Response To Radiation Nucleotide-excision Repair Telomere Organization DNA Replication Origin Binding Site Of Double-strand Break DNA Replication Regulation Of DNA Metabolic Process Damaged DNA Binding Chromosome Organization Single-stranded DNA Binding Mitotic DNA Integrity Checkpoint Signaling Nuclear Origin Of Replication Recognition Complex Cellular Response To Ionizing Radiation Regulation Of Cell Cycle Response To Light Stimulus Nucleotide-excision Repair Factor 1 Complex Response To Gamma Radiation DNA Replication Initiation Response To Stress Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process UV Protection Negative Regulation Of Cell Cycle DNA Damage Checkpoint Signaling DNA Replication Factor A Complex Regulation Of Cellular Response To Stress Response To UV PML Body Replicative Senescence Mitotic DNA Damage Checkpoint Signaling Base-excision Repair Checkpoint Clamp Complex Regulation Of Macromolecule Metabolic Process	Positive Regulation Of Complement Activation Complement Activation, Alternative Pathway Regulation Of Complement Activation Positive Regulation Of Humoral Immune Response Regulation Of Humoral Immune Response Positive Regulation Of Cytokine Production Positive Regulation Of Phagocytosis Positive Regulation Of Activation Of Membrane Attack Complex Response To Other Organism Complement Activation C5L2 Anaphylatoxin Chemotactic Receptor Binding Regulation Of Phagocytosis Positive Regulation Of Defense Response Activation Of Immune Response Telomere Maintenance Protein Phosphatase Binding CTP Binding Regulation Of Cell Size DATP Binding Neurofibrillary Tangle Assembly UTP Binding Positive Regulation Of Protein Localization To Nucleus Sulfonylurea Receptor Binding Positive Regulation Of Complement Activation, Alternative Pathway Cytoplasmic Side Of Golgi Membrane Response To External Biotic Stimulus Secretory Granule Lumen Complement-dependent Cytotoxicity Classical-complement-pathway C3/C5 Convertase Complex Vertebrate Eye-specific Patterning Rho GDP-dissociation Inhibitor Binding Telomere Organization Oviduct Epithelium Development Positive Regulation Of Type IIa Hypersensitivity Complement-mediated Synapse Pruning Protein Localization To Organelle Negative Regulation Of Nodal Signaling Pathway Regulation Of Protein Localization To Nucleus Positive Regulation Of Immune Response Positive Regulation Of Endocytosis Sperm Mitochondrial Sheath Regulation Of Complement Activation, Alternative Pathway Ragulator Complex Telomerase Holoenzyme Complex Assembly Regulation Of Cytokine Production Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Protein-containing Complex Positive Regulation Of Apoptotic Cell Clearance Chaperone-mediated Autophagy
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?