RPA2 and PRC1

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		RPA2	PRC1
Description		replication protein A2	protein regulator of cytokinesis 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm DNA Replication Factor A Complex Nuclear Body PML Body Site Of Double-strand Break	Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Plasma Membrane Microtubule Cytoskeleton Midbody Intercellular Bridge Contractile Ring Mitotic Spindle Midzone
	Molecular Function	DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Telomeric DNA Binding G-rich Strand Telomeric DNA Binding	Protein Binding Microtubule Binding Kinesin Binding Protein Kinase Binding Identical Protein Binding
	Biological Process	DNA Damage Checkpoint Signaling Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Base-excision Repair Nucleotide-excision Repair Mismatch Repair DNA Recombination DNA Damage Response Regulation Of Double-strand Break Repair Via Homologous Recombination Mitotic G1 DNA Damage Checkpoint Signaling Protein Localization To Chromosome Regulation Of DNA Damage Checkpoint	Mitotic Spindle Elongation Microtubule Cytoskeleton Organization Positive Regulation Of Cell Population Proliferation Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly Cell Division
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Removal of the Flap Intermediate from the C-strand Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HSF1 activation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Activation of the pre-replicative complex Removal of the Flap Intermediate G2/M DNA damage checkpoint Meiotic recombination Impaired BRCA2 binding to RAD51	RHO GTPases activate CIT
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)	Breast cancer ( 25038754 29059683) Mean platelet volume ( 27863252 32888494) Multisite chronic pain ( 31194737 33830993) Red cell distribution width ( 32888494) Type 2 diabetes ( 20581827 22885922 24509480 26818947 28869590 30054458 30297969 30718926 32499647)
Interacting Genes		69 interacting genes: ACP5 AKAP9 APP ATM CALCOCO2 CASK CCNC CCNO CDK1 CEBPA CEP126 CFB COPS6 CRMP1 DMRTB1 EEF1A1 ERCC1 ERCC4 EXOSC7 GAPDH GOLM1 HERPUD1 HIRA HNRNPUL1 HUS1 LNX2 LRIF1 MARK2 MCM2 MCM5 MED31 MEN1 NDEL1 ORC1 ORC2 ORC5 PCM1 PIAS1 PIAS4 PRC1 PRKDC RAD1 RAD51 RAD52 RAD9A RBM14 RBM48 RNF20 RNF40 RPA1 RPA3 RPLP1 SDF4 SERTAD3 SF1 SLC17A9 SMARCAL1 STAT3 TLE1 TP53 TUBB2A UNC119 UNG UTP14A WAS WRN XPA YWHAE ZBTB14	43 interacting genes: AKAP9 BICD2 CASK CCDC85B CCNA2 CCNB1 CCNE1 CDK1 CDK2 CEBPA CINP EMG1 EXOSC7 EXOSC8 FXR2 KIF3B KIF4A KLC2 KLC4 KRT20 LARP4 MAT2A NDEL1 NUDT16 OGT PBK PCM1 PKIA PLK1 PPIE RACGAP1 RBM10 RBM17 RBM22 RPA2 SF3B2 SLAIN1 SUMO2 TFIP11 THOC1 TRIM37 USHBP1 YWHAE
Entrez ID		6118	9055
HPRD ID		01566	17899
Ensembl ID		ENSG00000117748	ENSG00000198901
Uniprot IDs		B4DUL2 P15927	O43663
PDB IDs		1DPU 1L1O 1QUQ 1Z1D 2PI2 2PQA 2Z6K 3KDF 4MQV 4OU0 8RK2 9MJ5	3NRX 3NRY 4L3I 4L6Y 5KMG 7VBG
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Repair Chromosome, Telomeric Region Double-strand Break Repair Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoplasm DNA Damage Response Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Recombination Macromolecule Metabolic Process Response To Radiation Nucleus Telomere Maintenance Response To Ionizing Radiation Cellular Response To Stress Cellular Response To Radiation Nucleotide-excision Repair Telomere Organization DNA Replication Origin Binding Site Of Double-strand Break DNA Replication Regulation Of DNA Metabolic Process Damaged DNA Binding Chromosome Organization Single-stranded DNA Binding Mitotic DNA Integrity Checkpoint Signaling Nuclear Origin Of Replication Recognition Complex Cellular Response To Ionizing Radiation Regulation Of Cell Cycle Response To Light Stimulus Nucleotide-excision Repair Factor 1 Complex Response To Gamma Radiation DNA Replication Initiation Response To Stress Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process UV Protection Negative Regulation Of Cell Cycle DNA Damage Checkpoint Signaling DNA Replication Factor A Complex Regulation Of Cellular Response To Stress Response To UV PML Body Replicative Senescence Mitotic DNA Damage Checkpoint Signaling Base-excision Repair Checkpoint Clamp Complex Regulation Of Macromolecule Metabolic Process	Microtubule-based Process Nucleic Acid Metabolic Process Organelle Organization Microtubule Cytoskeleton Organization G2/M Transition Of Mitotic Cell Cycle Cytoskeleton Cell Cycle G2/M Phase Transition Cytoskeleton Organization Nucleobase-containing Compound Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Cell Cycle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Mitotic Cell Cycle Phase Transition Cytoplasm G1/S Transition Of Mitotic Cell Cycle Regulation Of Intracellular Protein Transport MRNA Metabolic Process Cell Cycle G1/S Phase Transition Nucleoplasm Nucleus Cell Cycle Phase Transition Centrosome Separation Centrosome Spindle Microtubule Microtubule Organizing Center RNA Metabolic Process Regulation Of Intracellular Transport Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Kinesin Complex Cyclin A2-CDK1 Complex Cyclin B1-CDK1 Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle MRNA Splicing, Via Spliceosome Regulation Of Proteasomal Protein Catabolic Process RNA Binding Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Nucleocytoplasmic Transport RNA Splicing, Via Transesterification Reactions Cell Division Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Cyclin-dependent Protein Kinase Activity U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Regulation Of Mitotic Cell Cycle Phase Transition Protein Localization To Organelle Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic DNA Damage Checkpoint Signaling
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