RPA2 and RAD52

Number of citations of the paper that reports this interaction (PMID 11081631)
71

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		RPA2	RAD52
Gene Name		replication protein A2, 32kDa	RAD52 homolog (S. cerevisiae)
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm DNA Replication Factor A Complex PML Body Site Of Double-strand Break	Nucleus Nucleoplasm
	Molecular Function	Damaged DNA Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Protein N-terminus Binding	DNA Binding Protein Binding Identical Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Double-strand Break Repair Regulation Of Double-strand Break Repair Via Homologous Recombination Mitotic G1 DNA Damage Checkpoint Telomere Maintenance Via Semi-conservative Replication Cellular Response To Heat Regulation Of Cellular Response To Heat Regulation Of DNA Damage Checkpoint	Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Repair Double-strand Break Repair DNA Recombination
Pathways		HSF1 activation Gap-filling DNA repair synthesis and ligation in TC-NER G2/M Checkpoints Repair synthesis for gap-filling by DNA polymerase in TC-NER Activation of the pre-replicative complex DNA strand elongation Mismatch Repair G1/S Transition Homologous recombination repair of replication-independent double-strand breaks Mitotic G1-G1/S phases Removal of the Flap Intermediate from the C-strand Chromosome Maintenance DNA Replication Pre-Initiation S Phase Removal of the Flap Intermediate Global Genomic NER (GG-NER) Nucleotide Excision Repair Activation of the pre-replicative complex Extension of Telomeres Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Assembly of the RAD51-ssDNA nucleoprotein complex Telomere Maintenance Activation of ATR in response to replication stress Processing of DNA double-strand break ends Double-Strand Break Repair Dual incision reaction in GG-NER Meiotic recombination Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand M/G1 Transition Cellular response to heat stress Regulation of HSF1-mediated heat shock response Telomere C-strand (Lagging Strand) Synthesis Presynaptic phase of homologous DNA pairing and strand exchange Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Homologous DNA pairing and strand exchange Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Transcription-coupled NER (TC-NER) Homologous Recombination Repair Formation of incision complex in GG-NER Cell Cycle Checkpoints	Assembly of the RAD51-ssDNA nucleoprotein complex Homologous DNA pairing and strand exchange Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair Presynaptic phase of homologous DNA pairing and strand exchange
Drugs
Diseases
GWAS			Lung cancer ( 22899653)
Protein-Protein Interactions		49 interactors: ACP5 APP ATM CALCOCO2 CCNO CDC5L CDK1 CFB COPS6 CRMP1 EEF1A1 EIF4G2 GAPDH GOLM1 HERPUD1 HNRNPUL1 HUS1 KIAA1377 LRIF1 MCM2 MCM3 MCM4 MCM5 MED31 MEN1 ORC1 ORC2 ORC4 ORC5 PRKDC PRPF19 RAD1 RAD52 RAD9A RBM48 RFWD3 RPA1 RPA3 RPLP1 SDF4 SERTAD3 SLC17A9 STAT3 TLE1 TUBB2A UNC119 UNG UTP14A XPA	12 interactors: ABL1 ERCC2 ERCC3 ERCC4 MCM2 MCM3 RAD51 RPA1 RPA2 SUMO1 UBE2I WRN
Entrez ID		6118	5893
HPRD ID		01566	11855
Ensembl ID		ENSG00000117748	ENSG00000002016
Uniprot IDs		P15927	F5GX32 P43351 Q3MI84 Q5DR82
PDB IDs		1DPU 1L1O 1QUQ 1Z1D 2PI2 2PQA 2Z6K 3KDF	1H2I 1KN0
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process Cell Cycle Process Cell Cycle DNA Replication Heterocycle Metabolic Process DNA Replication Initiation Mitotic Cell Cycle Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Cellular Aromatic Compound Metabolic Process DNA-dependent DNA Replication DNA Repair G1/S Transition Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Damage Checkpoint DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Response To Stress Cell Cycle Checkpoint Response To Radiation Cellular Metabolic Process Negative Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Response To Stress Biosynthetic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Ionizing Radiation Double-strand Break Repair Regulation Of Cell Cycle DNA Recombinase Assembly Response To Abiotic Stimulus DNA Recombination DNA Catabolic Process Cellular Macromolecule Catabolic Process Mitotic Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Aromatic Compound Catabolic Process Negative Regulation Of Mitotic Cell Cycle Cellular Response To Ionizing Radiation Regulation Of Cell Cycle Phase Transition Signal Transduction Involved In DNA Damage Checkpoint Metabolic Process	DNA Metabolic Process Nucleotide-excision Repair, DNA Damage Removal Cellular Response To DNA Damage Stimulus DNA Duplex Unwinding DNA Geometric Change DNA Repair DNA-dependent DNA Replication Transcription-coupled Nucleotide-excision Repair Organelle Organization Cellular Response To Stress Chromosome Organization Nucleotide-excision Repair DNA Strand Elongation Involved In DNA Replication DNA Recombinase Assembly DNA Strand Elongation DNA Conformation Change DNA Replication Nucleotide-excision Repair, DNA Incision DNA Catabolic Process Cell Cycle Process Double-strand Break Repair UV Protection Cell Cycle Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Recombination Nucleobase-containing Compound Metabolic Process Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Abiotic Stimulus Mitotic Recombination Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Process Response To UV Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Protein-DNA Complex Assembly Nitrogen Compound Metabolic Process Cellular Macromolecule Catabolic Process Response To Radiation Aromatic Compound Catabolic Process Mismatch Repair Base-excision Repair Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Catabolic Process DNA Unwinding Involved In DNA Replication Nucleic Acid Phosphodiester Bond Hydrolysis
Tagcloud ?		53bp1 accurately atm azd2281 brca1 brca2 characterizing cyclina2 ddr deficiencies distngiushed etoposide functionality genotoxins h2ax haploinsuffiency hrr joining mechanistically muted nhej normalize parpi pkcs predisposition proficient readouts scnp temozolomide	analogous bait biol chem conjugate conjugated conjugating epf gly gst hhr6b insert interact kamitani mercaptoethanol nguyen placenta precipitated rad51 rangap1 sentrin sentrinization tnfr1 translated ubc9 ubch5b ubch6 weakly yeh
Tagcloud (Difference) ?		53bp1 accurately atm azd2281 brca1 brca2 characterizing cyclina2 ddr deficiencies distngiushed etoposide functionality genotoxins h2ax haploinsuffiency hrr joining mechanistically muted nhej normalize parpi pkcs predisposition proficient readouts scnp temozolomide	analogous bait biol chem conjugate conjugated conjugating epf gly gst hhr6b insert interact kamitani mercaptoethanol nguyen placenta precipitated rad51 rangap1 sentrin sentrinization tnfr1 translated ubc9 ubch5b ubch6 weakly yeh
Tagcloud (Intersection) ?