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RPA2 and RAD52
Number of citations of the paper that reports this interaction (PubMedID
24126761
)
21
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro)
RPA2
RAD52
Description
replication protein A2
RAD52 DNA repair protein
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Nuclear Body
PML Body
Site Of Double-strand Break
Nucleus
Nucleoplasm
Protein-containing Complex
Protein-DNA Complex
Molecular Function
DNA Binding
Damaged DNA Binding
Single-stranded DNA Binding
Protein Binding
Enzyme Binding
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
Telomeric DNA Binding
G-rich Strand Telomeric DNA Binding
DNA Binding
Single-stranded DNA Binding
Protein Binding
Identical Protein Binding
Biological Process
DNA Damage Checkpoint Signaling
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Replication
DNA Repair
Base-excision Repair
Nucleotide-excision Repair
Mismatch Repair
DNA Recombination
DNA Damage Response
Regulation Of Double-strand Break Repair Via Homologous Recombination
Mitotic G1 DNA Damage Checkpoint Signaling
Protein Localization To Chromosome
Regulation Of DNA Damage Checkpoint
Double-strand Break Repair Via Homologous Recombination
DNA Recombinase Assembly
DNA Repair
Double-strand Break Repair
DNA Recombination
Mitotic Recombination
DNA Damage Response
DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing
Cellular Response To Oxidative Stress
Double-strand Break Repair Via Single-strand Annealing
Regulation Of Nucleotide-excision Repair
Pathways
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Removal of the Flap Intermediate from the C-strand
Activation of ATR in response to replication stress
Regulation of HSF1-mediated heat shock response
HSF1 activation
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
Activation of the pre-replicative complex
Removal of the Flap Intermediate
G2/M DNA damage checkpoint
Meiotic recombination
Impaired BRCA2 binding to RAD51
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through MMEJ (alt-NHEJ)
Drugs
Diseases
GWAS
HDL cholesterol levels (
32203549
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
White blood cell count (
32888494
)
Body mass index (
26426971
)
Eosinophil percentage of granulocytes (
27863252
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Immature fraction of reticulocytes (
32888494
)
Lung cancer (
22899653
)
Neutrophil percentage of granulocytes (
27863252
)
Small cell lung carcinoma (
28604730
)
Systolic blood pressure (
30224653
30578418
)
Youthful appearance (self-reported) (
32339537
)
Interacting Genes
69 interacting genes:
ACP5
AKAP9
APP
ATM
CALCOCO2
CASK
CCNC
CCNO
CDK1
CEBPA
CEP126
CFB
COPS6
CRMP1
DMRTB1
EEF1A1
ERCC1
ERCC4
EXOSC7
GAPDH
GOLM1
HERPUD1
HIRA
HNRNPUL1
HUS1
LNX2
LRIF1
MARK2
MCM2
MCM5
MED31
MEN1
NDEL1
ORC1
ORC2
ORC5
PCM1
PIAS1
PIAS4
PRC1
PRKDC
RAD1
RAD51
RAD52
RAD9A
RBM14
RBM48
RNF20
RNF40
RPA1
RPA3
RPLP1
SDF4
SERTAD3
SF1
SLC17A9
SMARCAL1
STAT3
TLE1
TP53
TUBB2A
UNC119
UNG
UTP14A
WAS
WRN
XPA
YWHAE
ZBTB14
25 interacting genes:
ABL1
AURKB
DCP1A
ERCC1
ERCC2
ERCC3
ERCC4
KPNA3
KPNA5
MCM2
MCM3
MEOX1
MEOX2
NFYC
PAX5
PLK3
RAD51
RDM1
RPA1
RPA2
SEM1
SUMO1
TTK
UBE2I
WRN
Entrez ID
6118
5893
HPRD ID
01566
11855
Ensembl ID
ENSG00000117748
ENSG00000002016
Uniprot IDs
B4DUL2
P15927
B7Z2G8
B7Z5Q6
F5GX32
P43351
Q5DR82
PDB IDs
1DPU
1L1O
1QUQ
1Z1D
2PI2
2PQA
2Z6K
3KDF
4MQV
4OU0
8RK2
9MJ5
1H2I
1KN0
5JRB
5XRZ
5XS0
8BJM
8H1P
8RIL
8RJ3
8RJW
8TKQ
Enriched GO Terms of Interacting Partners
?
DNA Metabolic Process
DNA Repair
Chromosome, Telomeric Region
Double-strand Break Repair
Nucleic Acid Metabolic Process
Nucleobase-containing Compound Metabolic Process
Nucleoplasm
DNA Damage Response
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
DNA Recombination
Macromolecule Metabolic Process
Response To Radiation
Nucleus
Telomere Maintenance
Response To Ionizing Radiation
Cellular Response To Stress
Cellular Response To Radiation
Nucleotide-excision Repair
Telomere Organization
DNA Replication Origin Binding
Site Of Double-strand Break
DNA Replication
Regulation Of DNA Metabolic Process
Damaged DNA Binding
Chromosome Organization
Single-stranded DNA Binding
Mitotic DNA Integrity Checkpoint Signaling
Nuclear Origin Of Replication Recognition Complex
Cellular Response To Ionizing Radiation
Regulation Of Cell Cycle
Response To Light Stimulus
Nucleotide-excision Repair Factor 1 Complex
Response To Gamma Radiation
DNA Replication Initiation
Response To Stress
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
UV Protection
Negative Regulation Of Cell Cycle
DNA Damage Checkpoint Signaling
DNA Replication Factor A Complex
Regulation Of Cellular Response To Stress
Response To UV
PML Body
Replicative Senescence
Mitotic DNA Damage Checkpoint Signaling
Base-excision Repair
Checkpoint Clamp Complex
Regulation Of Macromolecule Metabolic Process
DNA Repair
DNA Damage Response
DNA Metabolic Process
Nucleus
Double-strand Break Repair
Recombinational Repair
Double-strand Break Repair Via Homologous Recombination
DNA Recombination
Chromosome, Telomeric Region
Nucleotide-excision Repair
Single-stranded DNA Binding
Damaged DNA Binding
Regulation Of DNA Metabolic Process
DNA Binding
UV Protection
Nucleoplasm
Cellular Response To Stress
Telomere Maintenance
Protein Localization To Organelle
PML Body
Nucleic Acid Metabolic Process
Chromosome Organization
Telomere Organization
Mismatch Repair
Response To UV
Response To Radiation
DNA Helicase Activity
Nucleobase-containing Compound Metabolic Process
3'-5' DNA Helicase Activity
Regulation Of Nucleobase-containing Compound Metabolic Process
Telomere Maintenance Via Recombination
Helicase Activity
ATP Binding
DNA Replication
Repair Of Mitotic Kinetochore Microtubule Attachment Defect
DNA Conformation Change
Single-stranded DNA Helicase Activity
Regulation Of Cell Cycle Phase Transition
Mitotic Recombination
Cellular Response To Radiation
Regulation Of Mitotic Cell Cycle
Telomeric DNA-containing Double Minutes Formation
Nucleotide-excision Repair Factor 1 Complex
Response To Light Stimulus
Negative Regulation Of Protection From Non-homologous End Joining At Telomere
Macromolecule Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Mitotic Cell Cycle
Nucleotide Binding
Response To Oxidative Stress
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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