OTUD6A and POM121

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OTUD6A	POM121
Description		OTU deubiquitinase 6A	POM121 transmembrane nucleoporin
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Membrane
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore
	Biological Process	Proteolysis Protein Deubiquitination Protein K29-linked Deubiquitination Protein K11-linked Deubiquitination Protein K27-linked Deubiquitination Protein K33-linked Deubiquitination	RNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Protein Transport MRNA Transport
Pathways			ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS			Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Subcutaneous adipose tissue ( 22589738) Triglyceride levels ( 32203549)
Interacting Genes		19 interacting genes: CBLC CFTR DPYSL3 DYNLL1 DYNLL2 EMX2 MYCL NUP62 PDLIM7 POM121 RBCK1 RNF2 SSBP1 TRIM39 TRIM46 TRIM5 TRIM7 UBC VPS52	42 interacting genes: AGR2 AP1B1 AP2B1 APC ATXN1 BOLL BRCA1 CCDC57 CEACAM6 CEP55 CEP76 CERT1 CLDN3 COG6 FAM168B FXR2 GFAP GOLGA2 GYG1 HOMER3 JMJD7 KPNA6 LPXN MAGED1 MORN5 NFKBIA OTUD6A PAXIP1 RBPMS SPAG5 STAT3 TEX11 TFIP11 TOX3 TRAF2 TRAF3 TRIM23 TRIM27 TRIM49 TRIP6 UBQLN2 ZMYND12
Entrez ID		139562	9883
HPRD ID		13681	11448
Ensembl ID		ENSG00000189401	ENSG00000196313
Uniprot IDs		Q7L8S5	Q96HA1
PDB IDs			5T6W
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Cytoplasmic Dynein Complex Structural Constituent Of Nuclear Pore Filamentous Actin Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Stereocilium Bundle Organization Regulation Of DNA-binding Transcription Factor Activity Embryonic Ectodermal Digestive Tract Development Dynein Intermediate Chain Binding Dynein Complex Microtubule Associated Complex Negative Regulation Of ERBB Signaling Pathway Myosin V Complex Protein Modification Process Ciliary Tip Positive Regulation Of Anion Channel Activity Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Identical Protein Binding Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Helicase Activity Positive Regulation Of Mitochondrial DNA Replication Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Axon Cytoplasm Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Anterograde Dense Core Granule Transport Omegasome Cholesterol Transport Sterol Transport Regulation Of Protein Localization Positive Regulation Of Monoatomic Anion Transport RING-like Zinc Finger Domain Binding Zinc Ion Binding Regulation Of Mitochondrial DNA Replication Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Scaffold Protein Binding Nitric-oxide Synthase Inhibitor Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway PTB Domain Binding Proximal Neuron Projection	Identical Protein Binding Protein Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Cytoplasm Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Transport Protein Kinase Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Signal Transduction Involved In Regulation Of Gene Expression Establishment Of Protein Localization Establishment Of Localization In Cell Ubiquitin Protein Ligase Activity Intracellular Protein Transport Regulation Of Autophagy Thioesterase Binding CD40 Receptor Complex Clathrin Adaptor Complex Ubiquitin-protein Transferase Activity Tumor Necrosis Factor-mediated Signaling Pathway Cytosol Positive Regulation Of Multicellular Organismal Process Negative Regulation Of DNA-binding Transcription Factor Activity Response To Stress Transcription Coactivator Activity Regulation Of Cytokine Production Cellular Localization Ubiquitin Protein Ligase Binding Protein Transport Regulation Of DNA-binding Transcription Factor Activity Protein Localization To Nucleus Signaling Adaptor Activity Microtubule Organizing Center Organization Regulation Of Cytokine Production Involved In Inflammatory Response
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