OTUD6A and MYCL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OTUD6A	MYCL
Description		OTU deubiquitinase 6A	MYCL proto-oncogene, bHLH transcription factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Chromatin Nucleus Nucleoplasm Chromosome
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity
	Biological Process	Proteolysis Protein Deubiquitination Protein K29-linked Deubiquitination Protein K11-linked Deubiquitination Protein K27-linked Deubiquitination Protein K33-linked Deubiquitination	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Inner Ear Auditory Receptor Cell Differentiation
Pathways
Drugs
Diseases
GWAS
Interacting Genes		19 interacting genes: CBLC CFTR DPYSL3 DYNLL1 DYNLL2 EMX2 MYCL NUP62 PDLIM7 POM121 RBCK1 RNF2 SSBP1 TRIM39 TRIM46 TRIM5 TRIM7 UBC VPS52	6 interacting genes: CATSPER1 CCNK MAX MXD1 OTUD6A PRKAA2
Entrez ID		139562	4610
HPRD ID		13681	01279
Ensembl ID		ENSG00000189401	ENSG00000116990
Uniprot IDs		Q7L8S5	P12524
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Cytoplasmic Dynein Complex Structural Constituent Of Nuclear Pore Filamentous Actin Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Stereocilium Bundle Organization Regulation Of DNA-binding Transcription Factor Activity Embryonic Ectodermal Digestive Tract Development Dynein Intermediate Chain Binding Dynein Complex Microtubule Associated Complex Negative Regulation Of ERBB Signaling Pathway Myosin V Complex Protein Modification Process Ciliary Tip Positive Regulation Of Anion Channel Activity Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Identical Protein Binding Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Helicase Activity Positive Regulation Of Mitochondrial DNA Replication Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Axon Cytoplasm Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Anterograde Dense Core Granule Transport Omegasome Cholesterol Transport Sterol Transport Regulation Of Protein Localization Positive Regulation Of Monoatomic Anion Transport RING-like Zinc Finger Domain Binding Zinc Ion Binding Regulation Of Mitochondrial DNA Replication Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Scaffold Protein Binding Nitric-oxide Synthase Inhibitor Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway PTB Domain Binding Proximal Neuron Projection	Mad-Max Complex Myc-Max Complex [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Histone H2BS36 Kinase Activity Cyclin K-CDK13 Complex Cyclin K-CDK12 Complex
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