OTUD6A and CBLC

Number of citations of the paper that reports this interaction (PMID 23105109)
4

Data Source:
BioGRID (two hybrid)

		OTUD6A	CBLC
Gene Name		OTU deubiquitinase 6A	Cbl proto-oncogene C, E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-specific Protease Activity	Phosphotyrosine Binding Signal Transducer Activity Epidermal Growth Factor Receptor Binding Calcium Ion Binding Zinc Ion Binding Ligase Activity SH3 Domain Binding Ubiquitin Protein Ligase Activity
	Biological Process	Proteolysis Protein K29-linked Deubiquitination Protein K11-linked Deubiquitination Protein K27-linked Deubiquitination Protein K33-linked Deubiquitination	Cell Surface Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Ubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CBLC RBCK1 RNF2 TRIM39 TRIM46 TRIM5 UBC	33 interactors: BIRC2 CHFR CKM CRK EGFR FYN GRB2 ITCH LYN NACAD OTUD6A OXA1L SH3GL3 SHC1 SPRY2 SRC TGFB1I1 TRAF4 TRIM46 TRIP6 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBE2I UBE2K UBE2L3 UBE2L6 UBE2R2 USP2 USP21 ZAP70
Entrez ID		139562	23624
HPRD ID		13681	09765
Ensembl ID		ENSG00000189401	ENSG00000142273
Uniprot IDs		Q7L8S5	Q9ULV8
PDB IDs			3OP0 3VRN 3VRO 3VRP 3VRQ 3VRR
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Protein Modification Process Protein Polyubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Metabolic Process Regulation Of ERBB Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Signaling Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death T Cell Receptor Signaling Pathway Protein Catabolic Process Positive Regulation Of Cell Death Regulation Of MAPK Cascade Positive Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Histone H2A-K119 Monoubiquitination Antigen Receptor-mediated Signaling Pathway Activation Of Innate Immune Response Protein Linear Polyubiquitination Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Innate Immune Response Regulation Of Immune Response Negative Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process Regulation Of Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway	Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Immune Response-regulating Signaling Pathway Cellular Macromolecule Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Innate Immune Response Protein K48-linked Ubiquitination Cellular Protein Modification Process Proteolysis Regulation Of Immune Response Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Immune Response Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Defense Response Proteasomal Protein Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Transferase Activity Catabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune System Process Protein Metabolic Process Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Protein Metabolic Process Response To Growth Factor Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Abiotic Stimulus Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Intracellular Signal Transduction Neurotrophin Signaling Pathway Pattern Recognition Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction
Tagcloud ?			adenosylcobalamin autosomal az0348 cobalamin congenital consequently convert create distortion embryos giant gt heterozygous homocysteine homozygous inherited insertion intron matings methylcobalamin methylmalonic midgestation mmachc modeled outgrowth recessive requirement unable wtsi
Tagcloud (Difference) ?			adenosylcobalamin autosomal az0348 cobalamin congenital consequently convert create distortion embryos giant gt heterozygous homocysteine homozygous inherited insertion intron matings methylcobalamin methylmalonic midgestation mmachc modeled outgrowth recessive requirement unable wtsi
Tagcloud (Intersection) ?