OTUD6A and EMX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OTUD6A	EMX2
Description		OTU deubiquitinase 6A	empty spiracles homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Chromatin Nucleus Axon Cell Projection
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Proteolysis Protein Deubiquitination Protein K29-linked Deubiquitination Protein K11-linked Deubiquitination Protein K27-linked Deubiquitination Protein K33-linked Deubiquitination	Neuron Migration Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Brain Development Response To Xenobiotic Stimulus Anterior/posterior Pattern Specification Regulation Of Gene Expression Dentate Gyrus Development Cerebral Cortex Regionalization Cell Proliferation In Forebrain Forebrain Cell Migration Cerebral Cortex Development Neuron Differentiation Forebrain Development Ureter Morphogenesis Stereocilium Bundle Organization
Pathways			Formation of the nephric duct
Drugs
Diseases
GWAS			Airflow obstruction ( 22837378) Celiac disease ( 23936387) Chronotype ( 30696823) Double-edged eyelids ( 29895819) Early cardiac repolarization ( 22683750) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Liver fibrosis (total hepatic collagen content) ( 32953199) Low tan response ( 29739929) Neuroticism ( 29255261) Obesity-related traits ( 23251661) Ovarian disease with few adhesions ( 28333195) Photic sneeze reflex ( 27182965) Pulmonary function in asthmatics ( 23541324) Response to quetiapine in schizophrenia ( 29503163) Serum uric acid levels ( 29403010 30993211) Skin pigmentation ( 30664655) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Urate levels ( 31578528)
Interacting Genes		19 interacting genes: CBLC CFTR DPYSL3 DYNLL1 DYNLL2 EMX2 MYCL NUP62 PDLIM7 POM121 RBCK1 RNF2 SSBP1 TRIM39 TRIM46 TRIM5 TRIM7 UBC VPS52	5 interacting genes: EIF4E GTF2A1L MEIS1 OTUD6A TLE2
Entrez ID		139562	2018
HPRD ID		13681	02495
Ensembl ID		ENSG00000189401	ENSG00000170370
Uniprot IDs		Q7L8S5	Q04743
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Cytoplasmic Dynein Complex Structural Constituent Of Nuclear Pore Filamentous Actin Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Stereocilium Bundle Organization Regulation Of DNA-binding Transcription Factor Activity Embryonic Ectodermal Digestive Tract Development Dynein Intermediate Chain Binding Dynein Complex Microtubule Associated Complex Negative Regulation Of ERBB Signaling Pathway Myosin V Complex Protein Modification Process Ciliary Tip Positive Regulation Of Anion Channel Activity Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Identical Protein Binding Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Helicase Activity Positive Regulation Of Mitochondrial DNA Replication Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Axon Cytoplasm Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Anterograde Dense Core Granule Transport Omegasome Cholesterol Transport Sterol Transport Regulation Of Protein Localization Positive Regulation Of Monoatomic Anion Transport RING-like Zinc Finger Domain Binding Zinc Ion Binding Regulation Of Mitochondrial DNA Replication Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Scaffold Protein Binding Nitric-oxide Synthase Inhibitor Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway PTB Domain Binding Proximal Neuron Projection	Eukaryotic Initiation Factor 4G Binding MRNA Cap Binding Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Neuron Differentiation Regulation Of Translation At Postsynapse Negative Regulation Of Neuron Differentiation Transcription Factor TFIIA Complex Protein K33-linked Deubiquitination Protein K27-linked Deubiquitination Protein K29-linked Deubiquitination Transcription Regulator Complex Cell Growth Involved In Cardiac Muscle Cell Development
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?