OTUD6A and TRIM46

Number of citations of the paper that reports this interaction (PMID 23105109)
4

Data Source:
BioGRID (two hybrid)

		OTUD6A	TRIM46
Gene Name		OTU deubiquitinase 6A	tripartite motif containing 46
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Intracellular
	Molecular Function	Ubiquitin-specific Protease Activity	Zinc Ion Binding
	Biological Process	Proteolysis Protein K29-linked Deubiquitination Protein K11-linked Deubiquitination Protein K27-linked Deubiquitination Protein K33-linked Deubiquitination
Pathways			Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS			Urate levels ( 23263486)
Protein-Protein Interactions		7 interactors: CBLC RBCK1 RNF2 TRIM39 TRIM46 TRIM5 UBC	17 interactors: AK5 BRCA1 CBLC MDM4 OTUD6A RNF125 RNF7 TK1 TRIM9 TSG101 UBE2U UBE2Z UCHL5 USP1 USP15 USP2 USP32
Entrez ID		139562	80128
HPRD ID		13681	15563
Ensembl ID		ENSG00000189401	ENSG00000163462
Uniprot IDs		Q7L8S5	B7Z3S2 B7Z4F9 F5GYK0 Q7Z4K8
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Protein Modification Process Protein Polyubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Metabolic Process Regulation Of ERBB Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Signaling Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death T Cell Receptor Signaling Pathway Protein Catabolic Process Positive Regulation Of Cell Death Regulation Of MAPK Cascade Positive Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Histone H2A-K119 Monoubiquitination Antigen Receptor-mediated Signaling Pathway Activation Of Innate Immune Response Protein Linear Polyubiquitination Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Innate Immune Response Regulation Of Immune Response Negative Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process Regulation Of Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Protein Deubiquitination Protein Modification By Small Protein Removal Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Metabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Protein Metabolic Process Catabolic Process Cellular Metabolic Process Monoubiquitinated Protein Deubiquitination Regulation Of Protein Metabolic Process Regulation Of Proteolysis Cellular Response To DNA Damage Stimulus Regulation Of Cellular Protein Metabolic Process Protein Polyubiquitination Cellular Response To Stress DNA Metabolic Process DNA Repair Positive Regulation Of Histone H4-K20 Methylation Fetal Process Involved In Parturition DADP Biosynthetic Process Positive Regulation Of Histone H4-K16 Acetylation Regulation Of DNA Repair Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Metabolic Process G0 To G1 Transition Skeletal Muscle Cell Proliferation Positive Regulation Of Histone H3-K9 Acetylation Histone H2B Conserved C-terminal Lysine Deubiquitination Protein K27-linked Deubiquitination Negative Regulation Of SNARE Complex Assembly DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Stabilization Signal Transduction In Response To DNA Damage Regulation Of Cell Cycle Arrest Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Protein K33-linked Deubiquitination Protein K29-linked Deubiquitination
Tagcloud ?			a1cf activins acvr1b acvrl1 ancestry atxn2 b3gnt4 baz1b consortium excretion fractional gout gugc hlf hnf4g implicate inhbb inhibins maf nfat5 painful prkag2 replicated sfmbt1 stc1 tmem171 ube2q2 urate vegfa
Tagcloud (Difference) ?			a1cf activins acvr1b acvrl1 ancestry atxn2 b3gnt4 baz1b consortium excretion fractional gout gugc hlf hnf4g implicate inhbb inhibins maf nfat5 painful prkag2 replicated sfmbt1 stc1 tmem171 ube2q2 urate vegfa
Tagcloud (Intersection) ?