RBL1 and FN1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RBL1	FN1
Description		RB transcriptional corepressor like 1	fibronectin 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex	Extracellular Region Fibrinogen Complex Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Apical Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Promoter-specific Chromatin Binding	Protease Binding Signaling Receptor Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Heparin Binding Peptidase Activator Activity Identical Protein Binding Proteoglycan Binding Receptor Ligand Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Cell Differentiation Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cellular Senescence	Angiogenesis Regulation Of Protein Phosphorylation Acute-phase Response Cell-substrate Junction Assembly Cell Adhesion Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Integrin-mediated Signaling Pathway Nervous System Development Heart Development Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Response To Wounding Positive Regulation Of Gene Expression Response To Muscle Activity Integrin Activation Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Wound Healing Endothelial Cell Migration Positive Regulation Of Axon Extension Positive Regulation Of Fibroblast Proliferation Biological Process Involved In Interaction With Symbiont Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Transforming Growth Factor Beta Production Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Monocyte Activation Neural Crest Cell Migration Involved In Autonomic Nervous System Development Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest G1/S-Specific Transcription Cyclin D associated events in G1	Platelet degranulation Degradation of the extracellular matrix Degradation of the extracellular matrix Fibronectin matrix formation Cell surface interactions at the vascular wall Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MAP2K and MAPK activation Interleukin-4 and Interleukin-13 signaling Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates PTK2 signaling Post-translational protein phosphorylation GPER1 signaling Attachment of bacteria to epithelial cells Signaling downstream of RAS mutants Signaling by RAF1 mutants ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Developmental Lineage of Pancreatic Ductal Cells
Drugs			Zinc Lanoteplase Ocriplasmin Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Height ( 25429064) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 28957414 32888494)	Apolipoprotein B levels ( 32203549) Cholesterol, total ( 26780889) Coronary artery disease ( 33020668 32469254 29212778 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 30578418) Iron status biomarkers (ferritin levels) ( 33536631) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899 32203549) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Myocardial infarction ( 33532862) Negative urgency ( 30718321) Pulse pressure ( 30578418 28135244 27841878) Systolic blood pressure ( 30578418 27841878) Total cholesterol levels ( 28334899) White blood cell count ( 32888494)
Interacting Genes		55 interacting genes: AOX1 BEGAIN BRCA1 BRF1 CCNA1 CCNA2 CCND1 CCNE1 CDK2 CDK4 CDK6 CEBPA CREG1 DGKZ DHX30 DYRK1A E2F1 E2F4 E2F5 EPHA2 FN1 GOLGA2 HDAC1 ID2 IRF3 KDM5A KMT5C LAMB2 MAPK6 MCM7 MYBL2 MYC NR2E3 NR4A1 NUCB1 PHB1 PLSCR1 PPP1R9B PPP2R3A RBBP8 RBBP9 RINT1 SMAD2 SMAD3 SMAD4 SMARCA4 SNRPD3 SNW1 SP1 SUV39H1 TAF1 TOP1 TP53BP1 TSC22D2 USP4	111 interacting genes: ADAMTS4 AMBP ANOS1 APCS ATXN10 ATXN7 C1QA CCN3 CD44 CDKN2A COL13A1 COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL6A2 COL7A1 COL9A1 COMP CRP CTSD CXCL12 DCN DSCR9 DUSP10 EGFR F13A1 FAM86B3P FASLG FBLN1 FBLN2 FST FSTL3 GALNT6 GRB2 GSN HGF HOXA1 HRG HSP90AA1 HSPG2 IGFBP3 IGFBP5 ITGA2B ITGA3 ITGA4 ITGA5 ITGA8 ITGB1 ITGB3 ITGB6 ITGB7 KLK3 KPNA2 LACRT LGALS3BP LPA LRG1 LTBP1 MAG MATN2 MEP1A MEP1B MIA MMP9 MTDH MTNR1A MYOC NR0B2 NT5E PELI2 PKD1 PLAT PLG PRELP PRPF40A RARA RBL1 REG3A RPS6KA5 RSPH1 SCGB1A1 SDC2 SGCA SH3GLB1 SKIL SMAD4 SMAD9 SPARC STAT5A TAB1 TAB2 TAC1 TGFBI TGM2 THBS1 TIMD4 TLR4 TMPRSS6 TNC TNFRSF11B TSHR TTN UBQLN1 VEGFA VHL
Entrez ID		5933	2335
HPRD ID		00312	00626
Ensembl ID		ENSG00000080839	ENSG00000115414
Uniprot IDs		P28749	B7ZLE5 P02751 Q9UQS6
PDB IDs		1H28 4YOO 4YOS 4YOZ 5TUV 7SMC 7SMD 7SME 7SMF	1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2MNU 2N1K 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG 4LXO 4MMX 4MMY 4MMZ 4PZ5 5DC0 5DC4 5DC9 5DFT 5J6Z 5J7C 5M0A 5N47 5N48 6HNF 6MFA 6MSV 6NAJ 6XAX 6XAY 7NWL 8PEQ
Enriched GO Terms of Interacting Partners?		Nucleoplasm Transcription Regulator Complex Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Phase Transition Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process DNA Damage Response Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Intracellular Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleus Cellular Response To Stress Mitotic Cell Cycle Phase Transition Response To Stress Cell Cycle Phase Transition Response To Growth Factor Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex DNA Binding	Extracellular Matrix Extracellular Region Extracellular Space Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Fibronectin Binding Extracellular Matrix Organization Extracellular Structure Organization Basement Membrane Collagen Trimer Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Integrin Binding Cell Adhesion Endoplasmic Reticulum Lumen Cell Surface Developmental Process Negative Regulation Of Multicellular Organismal Process Collagen Type IV Trimer Integrin Complex Signal Transduction Negative Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Response To Growth Factor Cell-matrix Adhesion Regulation Of Cell Adhesion Extracellular Matrix Binding Anatomical Structure Morphogenesis Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Regulation Of Vasculature Development Cell-cell Adhesion Positive Regulation Of Cell Migration Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Positive Regulation Of Locomotion Regulation Of Apoptotic Process Collagen-activated Signaling Pathway Regulation Of Angiogenesis Regulation Of Cell Motility Collagen Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cell-substrate Adhesion Cell Adhesion Mediated By Integrin Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Programmed Cell Death Regulation Of Cell Population Proliferation Regulation Of Locomotion Integrin-mediated Signaling Pathway
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