RBL1 and NR2E3

Number of citations of the paper that reports this interaction (PMID 17255935)
27

Data Source:
HPRD (in vivo)

		RBL1	NR2E3
Gene Name		retinoblastoma-like 1	nuclear receptor subfamily 2, group E, member 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex	Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	Protein Binding Transcription Factor Binding	Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Viral Process Chromatin Modification Regulation Of Lipid Kinase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Visual Perception Phototransduction Negative Regulation Of Cell Proliferation Gene Expression Intracellular Receptor Signaling Pathway Eye Photoreceptor Cell Development Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Rhodopsin Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Retina Development In Camera-type Eye
Pathways		Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Mitotic G1-G1/S phases TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer G0 and Early G1 Loss of Function of TGFBR1 in Cancer Cell Cycle, Mitotic Cyclin D associated events in G1 Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Metabolite levels (HVA/MHPG ratio) ( 23319000)
Protein-Protein Interactions		51 interactors: AOX1 BEGAIN BRCA1 BRF1 CCNA1 CCNA2 CCND1 CCNE1 CDK2 CDK4 CDK6 CEBPA CREG1 DGKZ DHX30 DYRK1A E2F4 E2F5 EPHA2 FN1 GOLGA2 HDAC1 ID2 IRF3 KDM5A LAMB2 MAPK6 MCM7 MYBL2 MYC NR2E3 NR4A1 NUCB1 PHB PLSCR1 PPP2R3A RBBP8 RBBP9 RINT1 SMAD2 SMAD3 SMAD4 SMARCA4 SNRPD3 SNW1 SP1 SUV39H1 SUV420H2 TAF1 TOP1 USP4	27 interactors: BCL11A CDK9 CRX DEDD2 DHX30 ELAVL2 HDAC1 HDAC3 HOXC13 IRF9 MYBBP1A NCOR1 NR1D1 NR3C1 POLR3D PPARG RARA RBBP4 RBBP7 RBFOX2 RBL1 RXRA RXRB SIN3A SNAPC1 TBL3 ZNF232
Entrez ID		5933	10002
HPRD ID		00312	05132
Ensembl ID		ENSG00000080839
Uniprot IDs		P28749	B6ZGU0 F1D8Q9 Q9Y5X4
PDB IDs		1H28
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Cell Cycle Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription, Initiation Positive Regulation Of Cellular Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Metabolic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Proliferation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Cell Cycle Process Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Mitotic Cell Cycle Process Negative Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Multicellular Organismal Development	RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA-templated Transcription, Initiation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Steroid Hormone Mediated Signaling Pathway Intracellular Receptor Signaling Pathway Cellular Metabolic Process Hormone-mediated Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Circadian Regulation Of Gene Expression Circadian Rhythm Rhythmic Process Cellular Response To Steroid Hormone Stimulus Chromatin Modification Positive Regulation Of Metabolic Process Chromatin Organization Regulation Of Receptor Biosynthetic Process Response To Organic Substance
Tagcloud ?		accounts adenocarcinoma applicable assist deaths diagnostics e2f6 effort expended facilitate gold hmga1 hnrpd interactome irf1 lung mirna nsclc qpcr screen silico sub suitable suv39h1 tf tfdp1 transcriptomics vital worldwide	11a causing compound correlates cytotoxic cytotoxicity eralpha excluding facilitate favorable hct116 hela implying isogenic mediator mutated nci null orphan p53 photoreceptor pleiotropic pnr responsive retain retinal systematic tamoxifen varying
Tagcloud (Difference) ?		accounts adenocarcinoma applicable assist deaths diagnostics e2f6 effort expended gold hmga1 hnrpd interactome irf1 lung mirna nsclc qpcr screen silico sub suitable suv39h1 tf tfdp1 transcriptomics vital worldwide	11a causing compound correlates cytotoxic cytotoxicity eralpha excluding favorable hct116 hela implying isogenic mediator mutated nci null orphan p53 photoreceptor pleiotropic pnr responsive retain retinal systematic tamoxifen varying
Tagcloud (Intersection) ?		facilitate