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RBL1 and IRF3
Number of citations of the paper that reports this interaction (PubMedID
21903422
)
55
Data Source:
BioGRID
(affinity chromatography technology, pull down)
RBL1
IRF3
Description
RB transcriptional corepressor like 1
interferon regulatory factor 3
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
Protein Binding
Promoter-specific Chromatin Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Domain Specific Binding
Identical Protein Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Gene Expression
Cell Differentiation
Regulation Of Lipid Kinase Activity
Regulation Of Cell Cycle
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Cellular Senescence
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Cytokine Production
Immune System Process
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
DNA Damage Response
Cell Surface Receptor Signaling Pathway
MRNA Transcription
Response To Bacterium
Regulation Of Gene Expression
Programmed Cell Death
Signal Transduction Involved In Regulation Of Gene Expression
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Type I Interferon Production
Response To Lipopolysaccharide
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
MDA-5 Signaling Pathway
Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Response To Exogenous DsRNA
Innate Immune Response
Positive Regulation Of Innate Immune Response
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Inflammatory Response
Defense Response To Virus
Type I Interferon-mediated Signaling Pathway
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Cellular Response To Exogenous DsRNA
Macrophage Apoptotic Process
Programmed Necrotic Cell Death
Cellular Response To Virus
Antiviral Innate Immune Response
CGAS/STING Signaling Pathway
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
G1/S-Specific Transcription
Cyclin D associated events in G1
ISG15 antiviral mechanism
IRF3 mediated activation of type 1 IFN
IRF3 mediated activation of type 1 IFN
DDX58/IFIH1-mediated induction of interferon-alpha/beta
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
Regulation of innate immune responses to cytosolic DNA
IRF3-mediated induction of type I IFN
Interferon gamma signaling
TICAM1-dependent activation of IRF3/IRF7
Interferon alpha/beta signaling
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
SARS-CoV-1 activates/modulates innate immune responses
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Evasion by RSV of host interferon responses
Drugs
Diseases
GWAS
Height (
25429064
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red cell distribution width (
28957414
32888494
)
Autoimmune thyroid disease (
32581359
)
Schizophrenia (
29483656
)
Vitiligo (
27723757
)
Interacting Genes
55 interacting genes:
AOX1
BEGAIN
BRCA1
BRF1
CCNA1
CCNA2
CCND1
CCNE1
CDK2
CDK4
CDK6
CEBPA
CREG1
DGKZ
DHX30
DYRK1A
E2F1
E2F4
E2F5
EPHA2
FN1
GOLGA2
HDAC1
ID2
IRF3
KDM5A
KMT5C
LAMB2
MAPK6
MCM7
MYBL2
MYC
NR2E3
NR4A1
NUCB1
PHB1
PLSCR1
PPP1R9B
PPP2R3A
RBBP8
RBBP9
RINT1
SMAD2
SMAD3
SMAD4
SMARCA4
SNRPD3
SNW1
SP1
SUV39H1
TAF1
TOP1
TP53BP1
TSC22D2
USP4
35 interacting genes:
CREBBP
EP300
EWSR1
FBXO7
GRIP1
HERC5
HSP90AA1
IKBKE
ILF3
IRF5
IRF7
JMJD6
MAPK8
MAVS
OGT
PEX19
PIAS4
PPIB
PRDX1
PSMD14
RB1
RBL1
RELA
SERPINB2
SGTA
SMURF2
SYT1
TBK1
TICAM1
TICAM2
TOMM70
TRIM26
TRIM55
TRIM63
UFL1
Entrez ID
5933
3661
HPRD ID
00312
04769
Ensembl ID
ENSG00000080839
ENSG00000126456
Uniprot IDs
P28749
E2GIM5
E2GIM6
E2GIM7
E2GIM8
E2GIM9
M0QYT9
Q14653
Q96GL3
PDB IDs
1H28
4YOO
4YOS
4YOZ
5TUV
7SMC
7SMD
7SME
7SMF
1J2F
1QWT
1T2K
1ZOQ
2O61
2O6G
2PI0
3A77
3QU6
5JEJ
5JEK
5JEL
5JEM
5JEO
5JER
6SIV
6SJA
7JFL
Enriched GO Terms of Interacting Partners
?
Nucleoplasm
Transcription Regulator Complex
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Cycle
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle G1/S Phase Transition
Regulation Of Cell Cycle Phase Transition
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of RNA Metabolic Process
DNA Damage Response
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Metabolic Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Cycle Process
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Intracellular Signal Transduction
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Nucleus
Cellular Response To Stress
Mitotic Cell Cycle Phase Transition
Response To Stress
Cell Cycle Phase Transition
Response To Growth Factor
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Mitotic Cell Cycle
Cyclin-dependent Protein Kinase Holoenzyme Complex
DNA Binding
Activation Of Innate Immune Response
Positive Regulation Of Type I Interferon Production
Defense Response To Virus
Response To Virus
Positive Regulation Of Innate Immune Response
Positive Regulation Of Interferon-beta Production
Immune System Process
Regulation Of Type I Interferon Production
Response To Other Organism
Response To External Biotic Stimulus
Innate Immune Response
Defense Response
Activation Of Immune Response
Regulation Of Defense Response
Canonical NF-kappaB Signal Transduction
Regulation Of Interferon-beta Production
Regulation Of Innate Immune Response
Positive Regulation Of Defense Response
Innate Immune Response-activating Signaling Pathway
Defense Response To Symbiont
Response To Stress
Defense Response To Other Organism
Positive Regulation Of Immune Response
Intracellular Signal Transduction
Regulation Of Immune Response
Immune Response
Positive Regulation Of Immune System Process
Cytoplasm
Immune Response-regulating Signaling Pathway
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Regulation Of Metabolic Process
Regulation Of Immune System Process
Protein Modification Process
Regulation Of Primary Metabolic Process
Immune Response-activating Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Positive Regulation Of Multicellular Organismal Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Cytokine Production
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Cytokine-mediated Signaling Pathway
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Response To Cytokine Stimulus
Positive Regulation Of Gene Expression
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Tagcloud (Intersection)
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