RBL1 and AOX1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RBL1	AOX1
Gene Name		retinoblastoma-like 1	aldehyde oxidase 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex	Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Transcription Factor Binding	Aldehyde Oxidase Activity Xanthine Dehydrogenase Activity Iron Ion Binding UDP-N-acetylmuramate Dehydrogenase Activity Electron Carrier Activity Molybdopterin Cofactor Binding Flavin Adenine Dinucleotide Binding NAD Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Viral Process Chromatin Modification Regulation Of Lipid Kinase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Inflammatory Response Vitamin B6 Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process Reactive Oxygen Species Metabolic Process
Pathways		Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Mitotic G1-G1/S phases TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer G0 and Early G1 Loss of Function of TGFBR1 in Cancer Cell Cycle, Mitotic Cyclin D associated events in G1 Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer	Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Vitamins B6 activation to pyridoxal phosphate Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism
Drugs
Diseases
GWAS			Intelligence ( 22449649)
Protein-Protein Interactions		51 interactors: AOX1 BEGAIN BRCA1 BRF1 CCNA1 CCNA2 CCND1 CCNE1 CDK2 CDK4 CDK6 CEBPA CREG1 DGKZ DHX30 DYRK1A E2F4 E2F5 EPHA2 FN1 GOLGA2 HDAC1 ID2 IRF3 KDM5A LAMB2 MAPK6 MCM7 MYBL2 MYC NR2E3 NR4A1 NUCB1 PHB PLSCR1 PPP2R3A RBBP8 RBBP9 RINT1 SMAD2 SMAD3 SMAD4 SMARCA4 SNRPD3 SNW1 SP1 SUV39H1 SUV420H2 TAF1 TOP1 USP4	5 interactors: ABCA1 CRKL GK RBL1 RCHY1
Entrez ID		5933	316
HPRD ID		00312	07537
Ensembl ID		ENSG00000080839	ENSG00000138356
Uniprot IDs		P28749	B4DNI5 Q06278
PDB IDs		1H28
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Cell Cycle Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription, Initiation Positive Regulation Of Cellular Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Metabolic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Proliferation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Cell Cycle Process Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Mitotic Cell Cycle Process Negative Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Multicellular Organismal Development	Glycerol-3-phosphate Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Interleukin-1 Beta Secretion Glycerol Catabolic Process Apolipoprotein A-I-mediated Signaling Pathway Interleukin-1 Secretion Negative Regulation Of Cholesterol Storage High-density Lipoprotein Particle Assembly Intracellular Cholesterol Transport Intracellular Sterol Transport Phospholipid Homeostasis Positive Regulation Of Metabolic Process Alcohol Metabolic Process Parathyroid Gland Development Platelet Dense Granule Organization Regulation Of Phosphorus Metabolic Process Phospholipid Efflux Glycerol-3-phosphate Metabolic Process Phagocytosis, Engulfment Response To Low-density Lipoprotein Particle Interleukin-1 Beta Production Cellular Response To Cholesterol Negative Regulation Of Macrophage Derived Foam Cell Differentiation Reverse Cholesterol Transport Response To Laminar Fluid Shear Stress Membrane Invagination Protein-lipid Complex Assembly Response To Lipoprotein Particle Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Storage Positive Regulation Of Cholesterol Transport Cellular Response To Organic Substance Regulation Of Cholesterol Efflux Response To Cholesterol Cholesterol Efflux Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cdc42 Protein Signal Transduction Cellular Carbohydrate Catabolic Process Glycerol Metabolic Process Cytokine Secretion Response To Fluid Shear Stress Regulation Of Cholesterol Transport Secretory Granule Organization Protein Autoubiquitination Triglyceride Biosynthetic Process Regulation Of Macrophage Derived Foam Cell Differentiation Anion Homeostasis
Tagcloud ?		accounts adenocarcinoma applicable assist deaths diagnostics e2f6 effort expended facilitate gold hmga1 hnrpd interactome irf1 lung mirna nsclc qpcr screen silico sub suitable suv39h1 tf tfdp1 transcriptomics vital worldwide	autophagosomes backgroundthe compromised conclusionshigh cultivation eliminated factory g3 glycosylation heterologous immature inverted leakage mark methanol pastoris pichia popular processed prolonged quickly resultsa retention rhil rhil10 shortened unfolded varies yield
Tagcloud (Difference) ?		accounts adenocarcinoma applicable assist deaths diagnostics e2f6 effort expended facilitate gold hmga1 hnrpd interactome irf1 lung mirna nsclc qpcr screen silico sub suitable suv39h1 tf tfdp1 transcriptomics vital worldwide	autophagosomes backgroundthe compromised conclusionshigh cultivation eliminated factory g3 glycosylation heterologous immature inverted leakage mark methanol pastoris pichia popular processed prolonged quickly resultsa retention rhil rhil10 shortened unfolded varies yield
Tagcloud (Intersection) ?