RGL2 and KPNA2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RGL2	KPNA2
Gene Name		ral guanine nucleotide dissociation stimulator-like 2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Intracellular	Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Ras Guanyl-nucleotide Exchange Factor Activity	Protein Binding Nuclear Localization Sequence Binding Protein Transporter Activity Histone Deacetylase Binding Poly(A) RNA Binding
	Biological Process	Ras Protein Signal Transduction Positive Regulation Of Ras GTPase Activity	Regulation Of DNA Recombination DNA Metabolic Process NLS-bearing Protein Import Into Nucleus Viral Process Cytokine-mediated Signaling Pathway
Pathways			ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: CCDC90B CRMP1 EEF1G HRAS KAT5 KAT7 KPNA2 KRAS NOTCH2NL NRAS RAC1 RALA RAP1B UNC119	104 interactors: ACTN1 ACTN4 ANKIB1 AP2B1 APOBEC1 APP ARL4A ARL5A BRCA1 BTBD2 CASP2 CCDC107 CDA CDK5RAP3 CHD3 CHEK2 CORO1B CREB3L3 CREBBP CSE1L CSNK1A1 CUL4B DCTN2 DDIT3 EP300 EPB41 FEZ2 FN1 FTH1 GART GMCL1 GRB2 H1F0 HAP1 HMG20A HNRNPC HOMER2 HOMEZ HSPA4 IFT20 IMMT INO80E ITK JUN KLC4 KPNB1 KRT18 KRT40 KRT8 LAMB2 LEF1 LZTS2 MAGED1 MAGEH1 MDFI MLH1 MORC3 MVP MYC NECAB2 NFKBIB NMNAT1 NR3C1 NUP153 NUP50 NUP62 NUTM1 PAX5 PLAG1 PNMA5 PRKD3 PTMA RAG1 RAN RANBP2 RBM48 RBPMS RECQL RELA RELB RGL2 RILP RNMT SART3 SERTAD3 SGK1 SLC2A2 SPRY1 SRPK1 TADA2A TAF3 TAF8 TANK TBPL2 TP53 TRAF1 TRIM54 TSC22D4 TXNIP UBR5 USHBP1 ZBTB7B ZC3H12A ZNF131
Entrez ID		5863	3838
HPRD ID		03810	02818
Ensembl ID		ENSG00000237441	ENSG00000182481
Uniprot IDs		O15211	P52292 Q7Z726
PDB IDs			1EFX 1QGK 1QGR 3FEX 3FEY 4E4V
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Rac Protein Signal Transduction Neurotrophin Signaling Pathway Positive Regulation Of Ras Protein Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Positive Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Chemotaxis Response To Growth Factor Small GTPase Mediated Signal Transduction Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Synaptic Transmission, GABAergic Regulation Of Rac Protein Signal Transduction Response To External Stimulus Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Axon Guidance Cellular Response To Organic Substance Regulation Of Kinase Activity Blood Coagulation Hemostasis Epithelial Tube Branching Involved In Lung Morphogenesis Response To Radiation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Kinase Activity Regulation Of Neuronal Synaptic Plasticity Visual Learning Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Activation Of MAPKK Activity Lung Morphogenesis Visual Behavior Axonogenesis Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Protein Phosphorylation Fc Receptor Signaling Pathway Wound Healing Actin Cytoskeleton Organization Response To Abiotic Stimulus Associative Learning Positive Regulation Of Cell Projection Organization Response To Organic Substance Neuron Projection Morphogenesis	Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Cellular Process RNA Biosynthetic Process Gene Expression Response To Stimulus Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Cell Death Death Apoptotic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process Programmed Cell Death Viral Process Organelle Organization Regulation Of Nucleic Acid-templated Transcription Signal Transduction Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Developmental Process Regulation Of Transcription, DNA-templated Signaling Positive Regulation Of Transcription, DNA-templated Protein Localization To Nucleus Macromolecule Biosynthetic Process Cellular Localization Cell Cycle Negative Regulation Of Biosynthetic Process Cell Communication Negative Regulation Of Nucleic Acid-templated Transcription Cellular Process Negative Regulation Of RNA Biosynthetic Process Cell Cycle Process Response To Stress Positive Regulation Of Gene Expression Nucleocytoplasmic Transport Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Nuclear Transport Positive Regulation Of Macromolecule Biosynthetic Process Multicellular Organismal Development
Tagcloud ?		21d abi3 abscisic aco4 albeit alternating biosynthetic della disparate domesticated dormancy dormant ethylene germinate germinating germination gibberellin hub hy5 imbibed imbibition leafy phenylpropanoid seeds spurge surge temperate temporary transcriptome	aggressive aggressiveness assembled attempt carcinomas curable diagnostics disregarding eic emgd endometrial entities figo immunoreactivity interplay introducing malignancy mediator mfe microarrays nucleocytoplasmic precancerous regimens surgically tmas trp53 tumour untreatable uterus
Tagcloud (Difference) ?		21d abi3 abscisic aco4 albeit alternating biosynthetic della disparate domesticated dormancy dormant ethylene germinate germinating germination gibberellin hub hy5 imbibed imbibition leafy phenylpropanoid seeds spurge surge temperate temporary transcriptome	aggressive aggressiveness assembled attempt carcinomas curable diagnostics disregarding eic emgd endometrial entities figo immunoreactivity interplay introducing malignancy mediator mfe microarrays nucleocytoplasmic precancerous regimens surgically tmas trp53 tumour untreatable uterus
Tagcloud (Intersection) ?