RGL2 and CRMP1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		RGL2	CRMP1
Description		ral guanine nucleotide dissociation stimulator like 2	collapsin response mediator protein 1
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GO Annotations	Cellular Component	Cytosol	Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Actin Cytoskeleton Dendrite Growth Cone Midbody Cell Projection Neuronal Cell Body Perikaryon Presynapse Postsynapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Dihydropyrimidinase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Filamin Binding Identical Protein Binding Phosphoprotein Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Ral Protein Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Nervous System Development Negative Regulation Of Neuron Projection Development Semaphorin-plexin Signaling Pathway Regulation Of Postsynapse Assembly
Pathways		RAF/MAP kinase cascade	CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)	Blood trace element (Zn levels) ( 23720494) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Metabolite levels ( 23823483) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		19 interacting genes: ADAMTSL4 CCDC90B CRMP1 CYSRT1 EEF1G GORASP2 HRAS KAT5 KAT7 KPNA2 KPRP KRAS KRTAP10-8 NOTCH2NLA NRAS RAC1 RALA RAP1B UNC119	81 interacting genes: AGR2 ALDH2 AMFR ANXA7 AP3M1 ARL15 AXIN1 BID BTBD2 CACNA1A CCDC106 CCL18 CCT7 CDK5RAP2 CDK5RAP3 DDX18 DISC1 DNAJB11 DPYSL2 DUSP4 EEF1D EIF2S2 EPN1 EXOSC8 FAS FTH1 FUBP1 FXR1 GNE GOLGA2 HDHD2 HGS HMGB1 HNRNPH1 HNRNPH3 HNRNPUL1 HSPE1 HTT IL33 KLHL20 LRRC1 LRRK2 LSM2 MAP3K20 MAPK8IP2 MCM3AP MOB4 MRPS12 NAT9 NDUFV2 NVL PAFAH1B3 PFN1 PLA2G2A PMF1 PPP1R8 PSMD11 RACK1 RGL2 RGS2 ROCK1 RPA2 RPS6KA5 RSPH1 RTN4 SAT1 SEPHS1 SERPINB9 SNRPG SPRY2 SRC TFG TK1 TRIP13 TSC22D1 UBE2A UBE2B VCP VIM YAE1 ZNF24
Entrez ID		5863	1400
HPRD ID		03810	03913
Ensembl ID		ENSG00000237441	ENSG00000072832
Uniprot IDs		A0A024RCS9 O15211	B3KT07 B3KV96 E9PD68 Q14194 Q96I11 X5DNI1
PDB IDs		8AU4 8B69	4B3Z
Enriched GO Terms of Interacting Partners?		G Protein Activity GDP Binding Small GTPase-mediated Signal Transduction GTPase Activity GTP Binding Ras Protein Signal Transduction Intracellular Signaling Cassette Regulation Of Neuronal Synaptic Plasticity Histone H4K16 Acetyltransferase Activity Intracellular Signal Transduction Histone H4 Acetyltransferase Activity Developmental Process Peptidyl-lysine Acetylation Positive Regulation Of Ruffle Assembly Cell Development Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Rac Protein Signal Transduction Regulation Of Receptor-mediated Endocytosis Histone Acetyltransferase Complex Regulation Of Long-term Neuronal Synaptic Plasticity Signal Transduction Golgi Membrane Regulation Of Ruffle Assembly Protein-containing Complex Binding Negative Regulation Of Receptor-mediated Endocytosis Histone Acetyltransferase Activity Protein Acetylation Protein-membrane Adaptor Activity Endoplasmic Reticulum Membrane Establishment Of Skin Barrier Homeostasis Of Number Of Cells Within A Tissue Semaphorin-plexin Signaling Pathway Regulation Of Postsynapse Assembly Histone H2AK5 Acetyltransferase Activity Histone H3K23 Acetyltransferase Activity Histone H3K4 Acetyltransferase Activity Pigment Cell Development Skin Epidermis Development Hydrolase Activity Response To Radiation Endocytosis Regulation Of Cell Projection Assembly Regulation Of Synaptic Plasticity Positive Regulation Of Cellular Component Biogenesis Cellular Developmental Process GTPase Complex Cellular Senescence Modulation Of Chemical Synaptic Transmission MAPK Cascade Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin	Cytoplasm Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cytosol Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Identical Protein Binding RNA Binding Positive Regulation Of Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteolysis Protein Binding Protein-containing Complex Organization Organelle Organization Regulation Of Signal Transduction Cytoskeleton Organization Regulation Of Proteolysis Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Programmed Cell Death Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Mitochondrial Membrane Potential Cellular Component Assembly Nucleus Regulation Of Programmed Cell Death Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Regulation Of Protein Binding Regulation Of MAPK Cascade Protein-containing Complex Assembly Regulation Of Apoptotic Process Perinuclear Region Of Cytoplasm BAT3 Complex Binding Regulation Of Wnt Signaling Pathway Regulation Of Mitochondrial Depolarization Catabolic Process Positive Regulation Of Autophagy Regulation Of Cellular Response To Stress Regulation Of Protein Metabolic Process Regulation Of CAMKK-AMPK Signaling Cascade Negative Regulation Of Hippo Signaling HULC Complex Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Branching Morphogenesis Of A Nerve Ubiquitin-like Protein Ligase Binding Macromolecule Metabolic Process Microtubule Cytoskeleton Organization
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