RGL2 and RAP1B

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		RGL2	RAP1B
Gene Name		ral guanine nucleotide dissociation stimulator-like 2	RAP1B, member of RAS oncogene family
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Intracellular	Intracellular Lipid Particle Cytosol Plasma Membrane Cell-cell Junction Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Ras Guanyl-nucleotide Exchange Factor Activity	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Complex Binding
	Biological Process	Ras Protein Signal Transduction Positive Regulation Of Ras GTPase Activity	Blood Coagulation Cell Proliferation Microvillus Assembly Platelet Activation Rap Protein Signal Transduction Negative Regulation Of Calcium Ion-dependent Exocytosis Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Regulation Of Cell Junction Assembly Regulation Of Establishment Of Cell Polarity Negative Regulation Of Synaptic Vesicle Exocytosis
Pathways			Rap1 signalling p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) Adaptive Immune System
Drugs
Diseases
GWAS			White blood cell count ( 20139978)
Protein-Protein Interactions		14 interactors: CCDC90B CRMP1 EEF1G HRAS KAT5 KAT7 KPNA2 KRAS NOTCH2NL NRAS RAC1 RALA RAP1B UNC119	29 interactors: A2M ALAS1 APLP1 APP CCT7 CHGB CSAD DDAH2 FAF1 HRAS KMT2B LRIF1 PDHB PKM PRKACA RAB7B RALGDS RAPGEF1 RASSF5 RGL2 RGS2 RPTOR SDF4 SMURF2 TLE1 TP53 UNC119 ZDHHC17 ZNF135
Entrez ID		5863	5908
HPRD ID		03810	01546
Ensembl ID		ENSG00000237441	ENSG00000127314
Uniprot IDs		O15211	B7ZAY2 P61224
PDB IDs			3BRW 3CF6 4DXA 4HDO 4HDQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Rac Protein Signal Transduction Neurotrophin Signaling Pathway Positive Regulation Of Ras Protein Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Positive Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Chemotaxis Response To Growth Factor Small GTPase Mediated Signal Transduction Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Synaptic Transmission, GABAergic Regulation Of Rac Protein Signal Transduction Response To External Stimulus Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Axon Guidance Cellular Response To Organic Substance Regulation Of Kinase Activity Blood Coagulation Hemostasis Epithelial Tube Branching Involved In Lung Morphogenesis Response To Radiation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Kinase Activity Regulation Of Neuronal Synaptic Plasticity Visual Learning Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Activation Of MAPKK Activity Lung Morphogenesis Visual Behavior Axonogenesis Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Protein Phosphorylation Fc Receptor Signaling Pathway Wound Healing Actin Cytoskeleton Organization Response To Abiotic Stimulus Associative Learning Positive Regulation Of Cell Projection Organization Response To Organic Substance Neuron Projection Morphogenesis	Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Response To Light Stimulus Regulation Of Kinase Activity Intracellular Signal Transduction Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Phosphorylation Response To Radiation Programmed Cell Death Cell Death Death Negative Regulation Of Signal Transduction Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Component Biogenesis Cell Communication Positive Regulation Of Catalytic Activity Negative Regulation Of Signaling Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Negative Regulation Of Hydrolase Activity Apoptotic Process Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Blood Coagulation Hemostasis Neurotrophin Signaling Pathway Positive Regulation Of Hydrolase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Response To Abiotic Stimulus Positive Regulation Of Kinase Activity Regulation Of Cellular Component Organization
Tagcloud ?		21d abi3 abscisic aco4 albeit alternating biosynthetic della disparate domesticated dormancy dormant ethylene germinate germinating germination gibberellin hub hy5 imbibed imbibition leafy phenylpropanoid seeds spurge surge temperate temporary transcriptome	adp alphaiibbeta3 alzheimer apyrase atherothrombotic autocrine besides ca2 cerebrovascular collectively complement dense discovered discoveries fibrinogen granule gtpase integrin manage marginal p2y peptides platelet platelets signalling stimulant stimulates syk thrombus
Tagcloud (Difference) ?		21d abi3 abscisic aco4 albeit alternating biosynthetic della disparate domesticated dormancy dormant ethylene germinate germinating germination gibberellin hub hy5 imbibed imbibition leafy phenylpropanoid seeds spurge surge temperate temporary transcriptome	adp alphaiibbeta3 alzheimer apyrase atherothrombotic autocrine besides ca2 cerebrovascular collectively complement dense discovered discoveries fibrinogen granule gtpase integrin manage marginal p2y peptides platelet platelets signalling stimulant stimulates syk thrombus
Tagcloud (Intersection) ?