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KMT2C and HIST2H3C
Number of citations of the paper that reports this interaction (PMID
12482968
)
73
Data Source:
BioGRID
(pull down, enzymatic study)
KMT2C
HIST2H3C
Gene Name
lysine (K)-specific methyltransferase 2C
histone cluster 2, H3c
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Histone Methyltransferase Complex
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Extracellular Vesicular Exosome
Molecular Function
DNA Binding
Protein Binding
Zinc Ion Binding
Histone Methyltransferase Activity (H3-K4 Specific)
Poly(A) RNA Binding
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Biological Process
Chromatin Organization
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Intracellular Signal Transduction
Histone H3-K4 Methylation
Chromatin Silencing At RDNA
Blood Coagulation
Gene Expression
DNA Methylation On Cytosine
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Gene Expression, Epigenetic
Pathways
Chromatin modifying enzymes
Chromatin organization
PKMTs methylate histone lysines
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
Factors involved in megakaryocyte development and platelet production
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions
7 interactors:
HIST1H3A
HIST2H3C
JUN
MAPK14
SMARCB1
TSC22D1
WDR5
61 interactors:
ARID4A
ATRX
AURKB
BIRC5
BRD1
BRD4
BRD7
BRPF1
CDCA8
CDK8
CHUK
COPRS
DDB2
DNMT3L
EHMT2
ELP3
EP300
HDGFRP2
INCENP
ING1
JADE1
KAT2A
KAT2B
KAT5
KAT6A
KDM1A
KDM2A
KDM3A
KDM4C
KDM6A
KMT2A
KMT2B
KMT2C
KMT2D
MSL2
MUM1
NAP1L4
NASP
NCOA6
NRD1
PHF21A
PIM1
PKN1
PRMT6
PTMA
RBBP4
RBBP5
RERE
RNF20
RNF4
RPS6KA5
SETD1A
SETD1B
SETD7
SMARCA4
SMYD2
STAT6
TBL1X
UHRF1
VRK1
WHSC1
Entrez ID
58508
126961
HPRD ID
06016
11822
Ensembl ID
ENSG00000055609
Uniprot IDs
Q8NEZ4
Q71DI3
PDB IDs
2YSM
2YUK
3UVL
4ERY
2IIJ
2X4W
2X4X
2X4Y
3AV1
3DB3
3MO8
3QO2
3R93
Enriched GO Terms of Interacting Partners
?
Gene Expression
Positive Regulation By Host Of Viral Transcription
DNA Methylation On Cytosine
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Chromatin Silencing At RDNA
Regulation Of RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Response To Wounding
Interaction With Symbiont
Nitrogen Compound Metabolic Process
Chromatin Silencing
Positive Regulation Of Viral Transcription
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
DNA Methylation
TRIF-dependent Toll-like Receptor Signaling Pathway
Transcription, DNA-templated
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Regulation Of Viral Transcription
Methylation
RNA Biosynthetic Process
Blood Coagulation
MyD88-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Viral Process
Hemostasis
Negative Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Myeloid Cell Differentiation
Toll-like Receptor 4 Signaling Pathway
DNA Modification
Positive Regulation Of Transcription, DNA-templated
P38MAPK Cascade
Cellular Response To Potassium Ion Starvation
Regulation Of Metabolic Process
Gene Silencing
Toll-like Receptor Signaling Pathway
Regulation Of Body Fluid Levels
Chromatin Modification
Chromatin Organization
Histone Modification
Chromosome Organization
Peptidyl-lysine Modification
Organelle Organization
Peptidyl-amino Acid Modification
Transcription, DNA-templated
RNA Biosynthetic Process
Cellular Protein Modification Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
RNA Metabolic Process
Histone Methylation
Gene Expression
Peptidyl-lysine Methylation
Methylation
Cellular Macromolecule Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Protein Methylation
Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Histone Lysine Methylation
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Protein Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Histone Acetylation
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Protein Acetylation
Regulation Of Transcription From RNA Polymerase II Promoter
Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Protein Metabolic Process
Histone H3 Acetylation
Positive Regulation Of Cellular Biosynthetic Process
Histone H3-K4 Methylation
Regulation Of Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Cellular Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Gene Expression
Tagcloud
?
aacr
aggressive
ajuba
candidate
casp8
cdkn2a
clin
cscc
disfiguring
dominated
drive
driver
drivers
exome
fat1
foundation
hras
inactivating
lethal
links
mll3
mutational
mutsig
notch1
notch2
pard3
rasa1
res
suppressors
Tagcloud (Difference)
?
aacr
aggressive
ajuba
candidate
casp8
cdkn2a
clin
cscc
disfiguring
dominated
drive
driver
drivers
exome
fat1
foundation
hras
inactivating
lethal
links
mll3
mutational
mutsig
notch1
notch2
pard3
rasa1
res
suppressors
Tagcloud (Intersection)
?