KMT2C and HIST1H3A

Number of citations of the paper that reports this interaction (PMID 23870121)
8

Data Source:
BioGRID (enzymatic study)

		KMT2C	HIST1H3A
Gene Name		lysine (K)-specific methyltransferase 2C	histone cluster 1, H3a
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex	Nuclear Chromosome Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein Complex Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Poly(A) RNA Binding	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Intracellular Signal Transduction Histone H3-K4 Methylation	Chromatin Silencing At RDNA Chromatin Organization DNA Replication-dependent Nucleosome Assembly Blood Coagulation Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Silencing
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: HIST1H3A HIST2H3C JUN MAPK14 SMARCB1 TSC22D1 WDR5	117 interactors: AIRE AKT2 ALL1 ANP32A ASH1L ASH2L ATRX ATXN1 ATXN7 AURKB AURKC BAZ1B CALCOCO1 CARM1 CBX1 CBX3 CHD4 COPS2 CREBBP CTCFL CUL4A DDB1 DNMT3A DPF2 DYRK1A EED EHMT1 EHMT2 EID1 EP300 ERCC6 ESCO1 EZH2 FBLIM1 GATAD2A GATAD2B GRIP1 GSG2 HDAC2 HDAC8 HIST1H4A HIST2H2AC HIST2H4A HNF1B ING4 KAT2A KAT2B KAT5 KAT6A KAT7 KDM1A KDM2B KDM4A KDM4C KDM6A KDM6B KMT2A KMT2B KMT2C L3MBTL2 LBR LOXL2 MEN1 MSL3 MYOD1 NCOR1 NPM1 NR1H4 PAF1 PAK1 PARP10 PAXIP1 PBRM1 PHF1 PHF20 PHF8 PRDM2 PRKCA PRKCB PRMT1 PRMT5 PRMT7 RAD51B RAG1 RCC1 RPS6KA3 SET SETD1A SETD1B SETD2 SETD7 SETDB1 SIRT1 SIRT2 SIRT7 SMARCA2 SMARCA4 SMARCA5 SNAI1 SSRP1 SUV39H1 TAF1 TAF15 TAF1A TAF1B THAP7 TRIM24 TRIM33 TSSK6 UHRF1 UHRF2 VPRBP WHSC1 WWC1 YWHAB YWHAG YWHAZ
Entrez ID		58508	8350
HPRD ID		06016	04155
Ensembl ID		ENSG00000055609	ENSG00000198366
Uniprot IDs		Q8NEZ4	P68431
PDB IDs		2YSM 2YUK 3UVL 4ERY	1CS9 1CT6 1Q3L 2B2T 2B2U 2B2V 2B2W 2C1J 2C1N 2CV5 2KWJ 2KWK 2L75 2LBM 2M0O 2RI7 2UXN 3A1B 3AFA 3AVR 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3B95 3KMT 3KQI 3LQI 3LQJ 3O34 3O35 3O37 3RIG 3RIY 3U4S 3U5N 3U5O 3U5P 3UEE 3UEF 3UIG 3UII 3UIK 3V43 3W96 3W97 3W98 3W99 3ZG6 3ZVY 4A0J 4A0N 4A7J 4BD3 4F4U 4F56 4FWF 4HON 4I51
Enriched GO Terms of Interacting Partners?		Gene Expression Positive Regulation By Host Of Viral Transcription DNA Methylation On Cytosine Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Silencing At RDNA Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Wounding Interaction With Symbiont Nitrogen Compound Metabolic Process Chromatin Silencing Positive Regulation Of Viral Transcription Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway DNA Methylation TRIF-dependent Toll-like Receptor Signaling Pathway Transcription, DNA-templated MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Viral Transcription Methylation RNA Biosynthetic Process Blood Coagulation MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Viral Process Hemostasis Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Myeloid Cell Differentiation Toll-like Receptor 4 Signaling Pathway DNA Modification Positive Regulation Of Transcription, DNA-templated P38MAPK Cascade Cellular Response To Potassium Ion Starvation Regulation Of Metabolic Process Gene Silencing Toll-like Receptor Signaling Pathway Regulation Of Body Fluid Levels	Chromatin Modification Chromatin Organization Histone Modification Chromosome Organization Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Organelle Organization Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Macromolecule Biosynthetic Process Peptidyl-lysine Modification Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Cellular Protein Modification Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Peptidyl-amino Acid Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Histone Methylation Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Protein Methylation Cellular Metabolic Process Methylation Regulation Of Cellular Process Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic Histone Lysine Methylation Peptidyl-lysine Methylation Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression
Tagcloud ?		aacr aggressive ajuba candidate casp8 cdkn2a clin cscc disfiguring dominated drive driver drivers exome fat1 foundation hras inactivating lethal links mll3 mutational mutsig notch1 notch2 pard3 rasa1 res suppressors	1st affymetrix barcoding capn6 comprehensively corneal corneas dystrophies dystrophy fecd fecd4 fuchs genechip hcenc hspa2 hybridized itgbl1 nalcn partek polymorphous ppcd ppcd1 prex2 scientists suite tac1 tmod1 xecd
Tagcloud (Difference) ?		aacr aggressive ajuba candidate casp8 cdkn2a clin cscc disfiguring dominated drive driver drivers exome fat1 foundation hras inactivating lethal links mll3 mutational mutsig notch1 notch2 pard3 rasa1 res suppressors	1st affymetrix barcoding capn6 comprehensively corneal corneas dystrophies dystrophy fecd fecd4 fuchs genechip hcenc hspa2 hybridized itgbl1 nalcn partek polymorphous ppcd ppcd1 prex2 scientists suite tac1 tmod1 xecd
Tagcloud (Intersection) ?