KMT2C

Description		lysine methyltransferase 2C
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Histone Methyltransferase Complex MLL3/4 Complex
	Molecular Function	DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Acyltransferase Activity Histone Methyltransferase Activity Histone H3K4 Methyltransferase Activity Metal Ion Binding Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Methylation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS
Interacting Genes		14 interacting genes: APPL2 DPY30 H2AC4 H2BC3 H3-4 H3C1 H3C14 H4C1 JUN MAPK14 MTNR1B RNF10 SMARCB1 TSC22D1
Entrez ID		58508
HPRD ID		06016
Ensembl ID		ENSG00000055609
Uniprot IDs		Q8NEZ4
PDB IDs		2YSM 2YUK 3UVL 4ERY 5F59 5F6K 6KIW 6MLC 7W6L
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Chromatin Nucleosome Nucleosome Organization Protein-DNA Complex Assembly Chromatin Remodeling Nucleosome Assembly Chromatin Organization Protein Heterodimerization Activity Protein-containing Complex Assembly Protein-containing Complex Organization DNA Binding Chromosome Negative Regulation Of Cell Population Proliferation Nucleus Regulation Of Cell Development Epigenetic Regulation Of Gene Expression Regulation Of Cell Differentiation Host-mediated Activation Of Viral Transcription CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Regulation Of Cell Population Proliferation Response To Muscle Stretch Cellular Component Assembly Host-mediated Perturbation Of Viral Transcription Nuclear Chromosome Regulation Of Hemopoiesis Chromosome, Telomeric Region Host-mediated Activation Of Viral Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Localization To Chromosome, Centromeric Region Regulation Of Multicellular Organismal Development Positive Regulation Of Myoblast Differentiation Regulation Of Gene Expression Transcription Initiation-coupled Chromatin Remodeling Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Protein Localization To Chromatin Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Multicellular Organismal Process Positive Regulation Of Gene Expression, Epigenetic Regulation Of Macromolecule Biosynthetic Process Regulation Of D-glucose Import Nucleoplasm Negative Regulation Of Cell Development Regulation Of Developmental Process Leading Edge Cell Differentiation Positive Regulation Of Macropinocytosis Regulation Of D-glucose Transmembrane Transport Regulation Of Myoblast Differentiation Host-mediated Perturbation Of Viral Process Negative Regulation Of Cell Differentiation
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