KMT2C and SMARCB1

Number of citations of the paper that reports this interaction (PMID 19221051)
17

Data Source:
BioGRID (pull down, two hybrid)

		KMT2C	SMARCB1
Gene Name		lysine (K)-specific methyltransferase 2C	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex	Nuclear Chromatin XY Body Nucleus Nucleoplasm Nucleolus SWI/SNF Complex Protein Complex NpBAF Complex NBAF Complex
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Poly(A) RNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding P53 Binding Transcription Coactivator Activity Protein Binding Tat Protein Binding Nucleosomal DNA Binding
	Biological Process	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Intracellular Signal Transduction Histone H3-K4 Methylation	Blastocyst Hatching DNA Repair Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Nervous System Development Negative Regulation Of Cell Proliferation DNA Integration Cell Differentiation Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate ATP-dependent Chromatin Remodeling Positive Regulation By Host Of Viral Transcription Mitotic Cell Cycle Phase Transition Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines	Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS			IgG glycosylation ( 23382691)
Protein-Protein Interactions		7 interactors: HIST1H3A HIST2H3C JUN MAPK14 SMARCB1 TSC22D1 WDR5	40 interactors: AKT1 APP BCL2L11 CALR CDX2 CEBPB DPF2 DPF3 GADD45G GATA1 KLF1 KMT2B KMT2C MAP1LC3B MAPK8IP2 MCPH1 MECP2 MYC NONO NR0B2 NR3C1 PDPK1 PPP1CC PPP1R15A PRMT5 RAN RB1 RELB RPS6KA5 SIN3B SMARCA4 SRC TACC2 TAF1D TP53 UBQLN4 XPO1 YEATS4 ZAK ZDHHC17
Entrez ID		58508	6598
HPRD ID		06016	03364
Ensembl ID		ENSG00000055609	ENSG00000099956
Uniprot IDs		Q8NEZ4	G5E975 Q12824 Q9H836
PDB IDs		2YSM 2YUK 3UVL 4ERY
Enriched GO Terms of Interacting Partners?		Gene Expression Positive Regulation By Host Of Viral Transcription DNA Methylation On Cytosine Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Silencing At RDNA Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Wounding Interaction With Symbiont Nitrogen Compound Metabolic Process Chromatin Silencing Positive Regulation Of Viral Transcription Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway DNA Methylation TRIF-dependent Toll-like Receptor Signaling Pathway Transcription, DNA-templated MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Viral Transcription Methylation RNA Biosynthetic Process Blood Coagulation MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Viral Process Hemostasis Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Myeloid Cell Differentiation Toll-like Receptor 4 Signaling Pathway DNA Modification Positive Regulation Of Transcription, DNA-templated P38MAPK Cascade Cellular Response To Potassium Ion Starvation Regulation Of Metabolic Process Gene Silencing Toll-like Receptor Signaling Pathway Regulation Of Body Fluid Levels	Regulation Of Metabolic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Chromatin Organization Positive Regulation Of Metabolic Process Organelle Organization Transcription, DNA-templated Negative Regulation Of Biosynthetic Process RNA Biosynthetic Process Chromatin Modification Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Chromosome Organization Regulation Of Cellular Process RNA Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Organ Development Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation System Development Regulation Of Signaling Developmental Process Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Multicellular Organismal Development Negative Regulation Of Signal Transduction Regulation Of Phosphorylation Anatomical Structure Development Regulation Of Organelle Organization Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Phosphorus Metabolic Process
Tagcloud ?		aacr aggressive ajuba candidate casp8 cdkn2a clin cscc disfiguring dominated drive driver drivers exome fat1 foundation hras inactivating lethal links mll3 mutational mutsig notch1 notch2 pard3 rasa1 res suppressors	abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating
Tagcloud (Difference) ?		aacr aggressive ajuba candidate casp8 cdkn2a clin cscc disfiguring dominated drive driver drivers exome fat1 foundation hras inactivating lethal links mll3 mutational mutsig notch1 notch2 pard3 rasa1 res suppressors	abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating
Tagcloud (Intersection) ?