KMT2C and TSC22D1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		KMT2C	TSC22D1
Gene Name		lysine (K)-specific methyltransferase 2C	TSC22 domain family, member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex	Nucleus Cytoplasm
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Poly(A) RNA Binding	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Intracellular Signal Transduction Histone H3-K4 Methylation	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS			Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956)
Protein-Protein Interactions		7 interactors: HIST1H3A HIST2H3C JUN MAPK14 SMARCB1 TSC22D1 WDR5	49 interactors: A2M APLP1 ASAH1 C14orf1 C9orf9 CACNA1A CARHSP1 CCDC90B CHD3 CORO2B CRMP1 DDAH2 DNMT3B EED FAF1 FAM20C FBN3 GNB2 GNB5 HMGXB4 KMT2B KMT2C LRIF1 MAP3K12 MCM3AP NCOA5 OTUB1 PDHB PRKCI PTN QARS RGS1 RPL5 SETDB1 SP110 SPRED1 TAF5L TGFBR1 TLE1 TP53 TSC22D4 UBE2D1 UNC119 VIM WDR73 WDYHV1 WIZ WNK1 ZC3HC1
Entrez ID		58508	8848
HPRD ID		06016	07414
Ensembl ID		ENSG00000055609
Uniprot IDs		Q8NEZ4	A8K3Y6 Q15714
PDB IDs		2YSM 2YUK 3UVL 4ERY
Enriched GO Terms of Interacting Partners?		Gene Expression Positive Regulation By Host Of Viral Transcription DNA Methylation On Cytosine Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Silencing At RDNA Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Wounding Interaction With Symbiont Nitrogen Compound Metabolic Process Chromatin Silencing Positive Regulation Of Viral Transcription Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway DNA Methylation TRIF-dependent Toll-like Receptor Signaling Pathway Transcription, DNA-templated MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Viral Transcription Methylation RNA Biosynthetic Process Blood Coagulation MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Viral Process Hemostasis Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Myeloid Cell Differentiation Toll-like Receptor 4 Signaling Pathway DNA Modification Positive Regulation Of Transcription, DNA-templated P38MAPK Cascade Cellular Response To Potassium Ion Starvation Regulation Of Metabolic Process Gene Silencing Toll-like Receptor Signaling Pathway Regulation Of Body Fluid Levels	Regulation Of Metabolic Process Chromatin Organization Chromatin Modification Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cellular Process Regulation Of Cellular Protein Metabolic Process Chromosome Organization Regulation Of Chromosome Organization Regulation Of Histone Modification Regulation Of Protein Metabolic Process Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Histone Methylation Histone Modification Gene Expression Cellular Nitrogen Compound Metabolic Process Peptidyl-threonine Phosphorylation RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Signal Transduction Heterocycle Metabolic Process Regulation Of Histone Methylation Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Component Organization Signal Transduction Transcription, DNA-templated Cellular Response To Stimulus Negative Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Response To Stimulus Protein Methylation Positive Regulation Of Histone Modification Regulation Of Transcription, DNA-templated Organelle Organization Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Signaling Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Cell Communication Histone Lysine Methylation Negative Regulation Of Chromosome Organization Negative Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		aacr aggressive ajuba candidate casp8 cdkn2a clin cscc disfiguring dominated drive driver drivers exome fat1 foundation hras inactivating lethal links mll3 mutational mutsig notch1 notch2 pard3 rasa1 res suppressors	beadchip capn13 cards cic collect conjunctival cxcl6 cytology drb5 dry entire eye ht illumina impression investigates lysozyme mini optimally optimization psca qiagen qrt qualifying rneasy severities steps taqman transcriptome
Tagcloud (Difference) ?		aacr aggressive ajuba candidate casp8 cdkn2a clin cscc disfiguring dominated drive driver drivers exome fat1 foundation hras inactivating lethal links mll3 mutational mutsig notch1 notch2 pard3 rasa1 res suppressors	beadchip capn13 cards cic collect conjunctival cxcl6 cytology drb5 dry entire eye ht illumina impression investigates lysozyme mini optimally optimization psca qiagen qrt qualifying rneasy severities steps taqman transcriptome
Tagcloud (Intersection) ?