PIP5K1A and MIR34B

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		PIP5K1A	MIR34B
Description		phosphatidylinositol-4-phosphate 5-kinase type 1 alpha	microRNA 34b
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Plasma Membrane Focal Adhesion Membrane Nuclear Speck Lamellipodium Ruffle Membrane Cell Projection
	Molecular Function	Nucleotide Binding 1-phosphatidylinositol-3-phosphate 5-kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-4-phosphate 5-kinase Activity Transferase Activity Kinase Binding Phosphatidylinositol Kinase Activity 1-phosphatidylinositol-5-kinase Activity	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Lipid Metabolic Process Glycerophospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phagocytosis Signal Transduction Phospholipid Biosynthetic Process Fibroblast Migration Cell Migration Actin Cytoskeleton Organization Keratinocyte Differentiation Phosphatidylinositol Metabolic Process Phosphatidylinositol Phosphate Biosynthetic Process Focal Adhesion Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Chemotaxis Protein Localization To Plasma Membrane Activation Of GTPase Activity Ruffle Assembly	Negative Regulation Of Cell Population Proliferation MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Connective Tissue Replacement Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways		Synthesis of PIPs at the plasma membrane PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756)
Interacting Genes		16 interacting genes: APP ARF1 ARF5 ARF6 BTK CADPS CASP3 KRAS MIR140 MIR34B NEDD4 PIP5KL1 PLD1 PLD2 RHOU TEC	109 interacting genes: ADARB1 AIMP1 AIMP2 APOBEC3B AQR ATXN2 ATXN2L C1QBP CDC5L CELF1 CELF2 CPSF1 CPSF7 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FIP1L1 FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MTERF3 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PDCD11 PIP5K1A PLOD1 PTBP1 PTBP3 PTCD3 PUF60 PURA PURB QARS1 QKI RARS1 RBFOX2 RBM14 RBM4 RBM45 RBM4B RTCA RTCB SART3 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TENT2 TRA2A TRA2B TRIM56 U2SURP UPF1 USP36 UTP20 WDR33 XAB2 YBX1 YBX2 YBX3 ZFR ZNF346
Entrez ID		8394	407041
HPRD ID		04470
Ensembl ID		ENSG00000143398	ENSG00000207811
Uniprot IDs		A6PW57 Q99755
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Vesicle-mediated Transport Regulation Of Transport Regulation Of Biological Quality Vesicle-mediated Transport Intracellular Signal Transduction GTPase Activity Phospholipase D Activity GTP Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of Focal Adhesion Disassembly Establishment Of Localization In Cell Endocytosis Presynapse Plasma Membrane Nucleotide Binding Intracellular Signaling Cassette Response To External Biotic Stimulus Intracellular Copper Ion Homeostasis Golgi Apparatus Regulation Of Synaptic Vesicle Cycle Small GTPase-mediated Signal Transduction Negative Regulation Of B Cell Proliferation Copper Ion Homeostasis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Endocytosis Response To Light Stimulus Regulation Of Receptor-mediated Endocytosis Import Into Cell Response To Molecule Of Bacterial Origin Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Regulation Of Cell Communication Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Signaling Rac Protein Signal Transduction Phosphatidic Acid Biosynthetic Process Perinuclear Region Of Cytoplasm Regulation Of Interleukin-6 Production Negative Regulation Of Cell Population Proliferation Phosphatidic Acid Metabolic Process Regulation Of Rac Protein Signal Transduction Negative Regulation Of B Cell Activation Positive Regulation Of Inflammatory Response Glycerophospholipid Biosynthetic Process Regulation Of Tumor Necrosis Factor Production Focal Adhesion Regulation Of Signal Transduction MiRNA-mediated Gene Silencing By MRNA Destabilization Response To Radiation	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process RNA Splicing Nucleobase-containing Compound Metabolic Process MRNA Binding Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing RNA Splicing, Via Transesterification Reactions Nucleus Regulation Of MRNA Metabolic Process Nucleoplasm Post-transcriptional Regulation Of Gene Expression Aminoacyl-tRNA Synthetase Multienzyme Complex Ribonucleoprotein Complex Catalytic Step 2 Spliceosome Spliceosomal Complex Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Translation Cytoplasmic Stress Granule Negative Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding MiRNA Binding Negative Regulation Of RNA Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Translation TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Negative Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Metabolic Process RNA Stabilization TRNA Aminoacylation MRNA Stabilization Regulation Of Primary Metabolic Process Regulation Of RNA Stability RNA Transport Regulation Of MRNA Stability U2 SnRNP Positive Regulation Of Gene Expression Regulation Of Metabolic Process Ligase Activity Protein-RNA Complex Assembly
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