PIP5K1A and ARF1

Number of citations of the paper that reports this interaction (PubMedID 10589680)
0

Data Source:
HPRD (in vitro)

		PIP5K1A	ARF1
Description		phosphatidylinositol-4-phosphate 5-kinase type 1 alpha	ARF GTPase 1
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Plasma Membrane Focal Adhesion Membrane Nuclear Speck Lamellipodium Ruffle Membrane Cell Projection	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endomembrane System Postsynaptic Density Membrane Sarcomere Cell Leading Edge Protein-containing Complex Neuron Projection Synapse Extracellular Exosome
	Molecular Function	Nucleotide Binding 1-phosphatidylinositol-3-phosphate 5-kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-4-phosphate 5-kinase Activity Transferase Activity Kinase Binding Phosphatidylinositol Kinase Activity 1-phosphatidylinositol-5-kinase Activity	Nucleotide Binding Magnesium Ion Binding RNA Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein Domain Specific Binding
	Biological Process	Lipid Metabolic Process Glycerophospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phagocytosis Signal Transduction Phospholipid Biosynthetic Process Fibroblast Migration Cell Migration Actin Cytoskeleton Organization Keratinocyte Differentiation Phosphatidylinositol Metabolic Process Phosphatidylinositol Phosphate Biosynthetic Process Focal Adhesion Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Chemotaxis Protein Localization To Plasma Membrane Activation Of GTPase Activity Ruffle Assembly	Regulation Of Receptor Internalization Intracellular Copper Ion Homeostasis Intracellular Protein Transport Protein Transport Vesicle-mediated Transport Regulation Of Arp2/3 Complex-mediated Actin Nucleation Long-term Synaptic Depression Dendritic Spine Organization Cellular Response To Virus Mitotic Cleavage Furrow Ingression
Pathways		Synthesis of PIPs at the plasma membrane PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Nef Mediated CD4 Down-regulation trans-Golgi Network Vesicle Budding MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Glycosphingolipid transport
Drugs			1,3-Propanediol Guanosine-3'-monophosphate-5'-diphosphate Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate Brefeldin A Myristic acid Chlortetracycline Glycerin
Diseases
GWAS		Body mass index ( 26426971)	Adolescent idiopathic scoliosis ( 31417091)
Interacting Genes		16 interacting genes: APP ARF1 ARF5 ARF6 BTK CADPS CASP3 KRAS MIR140 MIR34B NEDD4 PIP5KL1 PLD1 PLD2 RHOU TEC	50 interacting genes: AGAP1 AGAP2 AP1B1 AP1G1 AP3B1 AP3D1 AP3S2 AP4E1 AP4M1 ARFGAP1 ARFIP1 ARFIP2 ARHGAP21 ASAP1 ASAP2 CHRM3 COPB1 COPE COPG1 CYTH1 CYTH2 DENND1A DENND1B DUX4 EEF1G ERBB2 GGA1 GGA2 GGA3 GORAB GOSR2 HTR2A INSR KDELR1 MDM4 NOA1 NPM1 PICK1 PIP5K1A PLD1 PLD2 PLEKHA8 PLIN2 RALA SCYL1 SNCA TMED10 TMED2 TMEM106A WBP11
Entrez ID		8394	375
HPRD ID		04470	00054
Ensembl ID		ENSG00000143398	ENSG00000143761
Uniprot IDs		A6PW57 Q99755	P84077
PDB IDs			1HUR 1RE0 1U81 3O47 4HMY 6CM9 6CRI 6D83 6D84 6DFF 6FAE 7DN8 7DN9 7MGE 7R4H 7UX3 8D4C 8D4D 8D4E 8D4F 8D4G 8D9R 8D9S 8D9U 8D9W 8SDW 9C58 9C59 9C5A 9C5B
Enriched GO Terms of Interacting Partners?		Regulation Of Vesicle-mediated Transport Regulation Of Transport Regulation Of Biological Quality Vesicle-mediated Transport Intracellular Signal Transduction GTPase Activity Phospholipase D Activity GTP Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of Focal Adhesion Disassembly Establishment Of Localization In Cell Endocytosis Presynapse Plasma Membrane Nucleotide Binding Intracellular Signaling Cassette Response To External Biotic Stimulus Intracellular Copper Ion Homeostasis Golgi Apparatus Regulation Of Synaptic Vesicle Cycle Small GTPase-mediated Signal Transduction Negative Regulation Of B Cell Proliferation Copper Ion Homeostasis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Endocytosis Response To Light Stimulus Regulation Of Receptor-mediated Endocytosis Import Into Cell Response To Molecule Of Bacterial Origin Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Regulation Of Cell Communication Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Signaling Rac Protein Signal Transduction Phosphatidic Acid Biosynthetic Process Perinuclear Region Of Cytoplasm Regulation Of Interleukin-6 Production Negative Regulation Of Cell Population Proliferation Phosphatidic Acid Metabolic Process Regulation Of Rac Protein Signal Transduction Negative Regulation Of B Cell Activation Positive Regulation Of Inflammatory Response Glycerophospholipid Biosynthetic Process Regulation Of Tumor Necrosis Factor Production Focal Adhesion Regulation Of Signal Transduction MiRNA-mediated Gene Silencing By MRNA Destabilization Response To Radiation	Vesicle-mediated Transport Intracellular Protein Localization Golgi Apparatus Protein Transport Establishment Of Protein Localization Cellular Localization Intracellular Transport Establishment Of Localization In Cell Golgi Vesicle Transport Intracellular Protein Transport Membrane Coat Golgi Membrane Cytoplasmic Vesicle Membrane COPI-coated Vesicle Membrane Trans-Golgi Network Membrane Melanosome Assembly Localization Within Membrane Platelet Dense Granule Organization Post-Golgi Vesicle-mediated Transport Vesicle Cargo Loading COPI Vesicle Coat COPI-coated Vesicle Melanosome Organization Pigment Granule Organization Endoplasmic Reticulum-Golgi Intermediate Compartment Protein Localization To Membrane Golgi To Vacuole Transport Early Endosome Transport Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Trans-Golgi Network Secretory Granule Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Localization To Cell Surface Intra-Golgi Vesicle-mediated Transport Organelle Organization Vesicle Organization Clathrin-coated Vesicle Membrane Synaptic Vesicle Transport Vesicle Coating AP-3 Adaptor Complex Protein Localization To Cell Periphery Endocytosis Clathrin Adaptor Complex Organelle Transport Along Microtubule Cytosol Synaptic Vesicle Budding From Endosome Vacuolar Transport
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