PIP5K1A and CADPS

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		PIP5K1A	CADPS
Gene Name		phosphatidylinositol-4-phosphate 5-kinase, type I, alpha	Ca++-dependent secretion activator
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Plasma Membrane Focal Adhesion Nuclear Speck Lamellipodium Ruffle Membrane	Cytosol Cell Junction Cytoplasmic Vesicle Membrane Synapse
	Molecular Function	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity Kinase Binding	Protein Binding Lipid Binding Protein Kinase Binding Metal Ion Binding
	Biological Process	Phospholipid Metabolic Process Glycerophospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phagocytosis Signal Transduction Phospholipid Biosynthetic Process Fibroblast Migration Cell Migration Keratinocyte Differentiation Actin Cytoskeleton Reorganization Activation Of Rac GTPase Activity Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation Focal Adhesion Assembly Cell Chemotaxis Protein Targeting To Plasma Membrane Ruffle Assembly	Exocytosis Protein Transport Vesicle Organization Synaptic Vesicle Priming Catecholamine Secretion
Pathways		Synthesis of PIPs at the plasma membrane Metabolism of lipids and lipoproteins Phospholipid metabolism PI Metabolism
Drugs
Diseases
GWAS			Breast size ( 22747683) Economic and political preferences (environmentalism) ( 22566634)
Protein-Protein Interactions		11 interactors: APP ARF1 ARF5 ARF6 BTK CADPS CASP3 PIP5KL1 PLD1 PLD2 TEC	13 interactors: C17orf67 C19orf66 DMD DRD2 FAM161A FAM9B KIAA1549 LUC7L2 PIP5K1A SDCBP TCL1A TTLL10 ZNF572
Entrez ID		8394	8618
HPRD ID		04470	05236
Ensembl ID		ENSG00000143398	ENSG00000163618
Uniprot IDs		A6PW57 Q99755	F1T0E5 Q9ULU8
PDB IDs			1WI1
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Signaling Cell Communication Glycerophospholipid Metabolic Process Phosphatidylglycerol Biosynthetic Process Glycerolipid Metabolic Process Phospholipid Metabolic Process Organelle Localization Response To Oxidative Stress Cellular Copper Ion Homeostasis Signal Transduction Copper Ion Homeostasis Phosphatidic Acid Biosynthetic Process Phosphatidic Acid Metabolic Process Phosphate-containing Compound Metabolic Process Glycerophospholipid Biosynthetic Process Establishment Of Vesicle Localization Vesicle Localization Peptidyl-tyrosine Autophosphorylation B Cell Receptor Signaling Pathway Phospholipid Biosynthetic Process Lipid Metabolic Process Regulation Of Immune System Process Immune System Process Defense Response Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Neuron Apoptotic Process Cellular Localization Innate Immune Response Establishment Of Organelle Localization Neuron Death Exocytosis Regulation Of B Cell Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Neuromuscular Process Controlling Balance Cellular Lipid Metabolic Process Apoptotic Process Programmed Cell Death Organophosphate Metabolic Process Synaptic Growth At Neuromuscular Junction Cellular Response To Molecule Of Fungal Origin Cell Death Death Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Synaptic Vesicle Transport	Cell Projection Assembly Cellular Component Assembly Cell Projection Organization Regulation Of Voltage-gated Calcium Channel Activity Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Sodium Ion Transport Cell Morphogenesis Regulation Of Heart Rate Regulation Of Cation Channel Activity Receptor Metabolic Process Positive Regulation Of Long-term Synaptic Potentiation Establishment Of Glial Blood-brain Barrier Synaptic Transmission Movement Of Cell Or Subcellular Component Regulation Of Ion Transmembrane Transporter Activity Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Peptidyl-cysteine S-nitrosylation Actin Filament-based Process Regulation Of Transmembrane Transporter Activity Regulation Of Ion Homeostasis Protein Targeting To Membrane Regulation Of Heart Contraction Positive Regulation Of Extracellular Vesicular Exosome Assembly Negative Regulation Of Dopamine Secretion Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Branching Morphogenesis Of A Nerve Positive Regulation Of Transport Anatomical Structure Development Cilium Assembly Negative Regulation Of Voltage-gated Calcium Channel Activity Orbitofrontal Cortex Development Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Establishment Of Blood-nerve Barrier Regulation Of Calcium Ion Transport Cell Development Cilium Organization Positive Regulation Of Ion Transport Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Long-term Synaptic Potentiation Regulation Of Dopamine Receptor Signaling Pathway Cell Migration Olfactory Nerve Development Positive Regulation Of Growth Hormone Secretion Protein Localization Muscle Contraction
Tagcloud ?		1q address akt3 amplified cascades copy cosmic encodes encoding enzymes evident extending iiibeta isozyme issue localize mutational neu numerically oncogenes phosphatidylinositol phosphoinositide pi3kc2b pi4kb quartet resource signalling structurally uncommon
Tagcloud (Difference) ?		1q address akt3 amplified cascades copy cosmic encodes encoding enzymes evident extending iiibeta isozyme issue localize mutational neu numerically oncogenes phosphatidylinositol phosphoinositide pi3kc2b pi4kb quartet resource signalling structurally uncommon
Tagcloud (Intersection) ?