PMP22 and FCGRT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PMP22	FCGRT
Description		peripheral myelin protein 22	Fc gamma receptor and transporter
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Bicellular Tight Junction Membrane Compact Myelin Synapse	Extracellular Space Endosome Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding IgG Binding Beta-2-microglobulin Binding Peptide Antigen Binding
	Biological Process	Apoptotic Process Chemical Synaptic Transmission Nervous System Development Peripheral Nervous System Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Projection Development Cell Differentiation Bleb Assembly Myelin Assembly Myelination	IgG Immunoglobulin Transcytosis In Epithelial Cells Mediated By FcRn Immunoglobulin Receptor Immune Response
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs			Efgartigimod alfa
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Allergic rhinitis ( 25085501) Amyotrophic lateral sclerosis ( 29566793) Corneal structure ( 23291589) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Preterm birth (maternal effect) ( 28877031) Resting heart rate ( 27798624)	Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 29403010) Hematocrit ( 32888494) Hematological and biochemical traits ( 20139978) Hemoglobin ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Serum albumin levels ( 23022100 29403010) Serum total protein levels ( 23022100) Total cholesterol levels ( 29403010) Triglyceride levels ( 32203549)
Interacting Genes		64 interacting genes: APOL3 AQP6 ARL13B ASGR2 ATP6AP2 BIK C16orf54 CANX CD3G CD53 CD69 CEACAM3 CLDN18 CLDN5 CLDN6 CLEC12B CLEC14A CREB3 CREB3L1 DDX52 EBP EDA EMP1 ERGIC3 FAM209A FCGRT FFAR2 GJA8 GPR42 GPR61 GPRC5D GPX8 IFNGR2 KCNJ6 KCNN4 KLRC1 LMNA MPZ MS4A7 OPRM1 PDZK1IP1 PEX19 PGRMC2 REEP4 SAR1A SCN3B SDC4 SHISAL1 SLC10A1 SLC18A1 SLC38A1 SMIM3 SPACA1 STOM SYT2 TLCD4 TM4SF18 TM4SF19 TMEM139 TMEM14B TMEM30B TMEM31 TMX1 TSPAN12	9 interacting genes: ALB B2M CA6 CLDN19 FAM3C MTDH NINJ2 PMP22 UPK2
Entrez ID		5376	2217
HPRD ID		03059	03257
Ensembl ID		ENSG00000109099	ENSG00000104870
Uniprot IDs		A0A2R8Y5L5 A8MU75 Q01453 Q6FH25	A0A024QZI2 M0R0A9 P55899
PDB IDs			1EXU 3M17 3M1B 4K71 4N0F 4N0U 5BJT 5BXF 5WHK 6C97 6C98 6C99 6FGB 6ILM 6LA6 6LA7 6NHA 6QIO 6QIP 6WNA 6WOL 7B5F 7C9V 7Q15 7XXA 9MI6
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Protein Binding Carbohydrate Binding External Side Of Plasma Membrane Natural Killer Cell Inhibitory Signaling Pathway Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Endoplasmic Reticulum Membrane Endoplasmic Reticulum	Bicellular Tight Junction
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