PMP22 and ASGR2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		PMP22	ASGR2
Name		peripheral myelin protein 22	asialoglycoprotein receptor 2
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Bicellular Tight Junction Membrane Compact Myelin Synapse	Plasma Membrane External Side Of Plasma Membrane Membrane Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Asialoglycoprotein Receptor Activity Protein Binding D-mannose Binding Carbohydrate Binding Pattern Recognition Receptor Activity Fucose Binding
	Biological Process	Apoptotic Process Chemical Synaptic Transmission Nervous System Development Peripheral Nervous System Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Projection Development Cell Differentiation Bleb Assembly Myelin Assembly Myelination	Endocytosis Immune Response Cell Surface Receptor Signaling Pathway
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination	Asparagine N-linked glycosylation
Drugs		None	Antihemophilic factor, human recombinant Lonoctocog alfa Moroctocog alfa
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy	None
GWAS		Allergic rhinitis ( 25085501 ) Amyotrophic lateral sclerosis ( 29566793 ) Corneal structure ( 23291589 ) Metabolite levels ( 23823483 ) Night sleep phenotypes ( 27126917 ) Preterm birth (maternal effect) ( 28877031 ) Resting heart rate ( 27798624 )	Congenital heart disease (maternal effect) ( 28468790 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Total cholesterol levels ( 30275531 )
Interacting Genes		64 interacting genes: APOL3 AQP6 ARL13B ASGR2 ATP6AP2 BIK C16orf54 CANX CD3G CD53 CD69 CEACAM3 CLDN18 CLDN5 CLDN6 CLEC12B CLEC14A CREB3 CREB3L1 DDX52 EBP EDA EMP1 ERGIC3 FAM209A FCGRT FFAR2 GJA8 GPR42 GPR61 GPRC5D GPX8 IFNGR2 KCNJ6 KCNN4 KLRC1 LMNA MPZ MS4A7 OPRM1 PDZK1IP1 PEX19 PGRMC2 REEP4 SAR1A SCN3B SDC4 SHISAL1 SLC10A1 SLC18A1 SLC38A1 SMIM3 SPACA1 STOM SYT2 TLCD4 TM4SF18 TM4SF19 TMEM139 TMEM14B TMEM30B TMEM31 TMX1 TSPAN12	50 interacting genes: ADAM33 ADIPOQ AIG1 ASGR1 ATP6V0C BET1 CD53 CERS2 CLEC17A CLEC7A EMP1 F8 FA2H FATE1 GLP1R GLUD1 HES1 HMOX2 IL1RL1 LAT LNPEP MCEMP1 MMD2 MROH5 MS4A13 NRG1 ORMDL1 PLN PLP2 PMP22 RPRM SEC22A SLC35A1 SLC35B2 SMIM3 SNCA STX8 TFRC TMEM140 TMEM60 TMEM86B TMPPE TRAM1L1 TSPO2 UBIAD1 UPK2 VAMP5 VKORC1 VTI1B YIPF1
Entrez ID		5376	433
HPRD ID		03059	00152
Ensembl ID		ENSG00000109099	ENSG00000161944
Uniprot IDs		A0A2R8Y5L5 A8MU75 Q01453 Q6FH25	P07307 Q7Z4G9
PDB IDs		Not available	8URF
GO Terms Enriched among Interactors		Membrane Plasma Membrane Protein Binding Carbohydrate Binding External Side Of Plasma Membrane Natural Killer Cell Inhibitory Signaling Pathway Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Endoplasmic Reticulum Membrane Endoplasmic Reticulum	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity Protein Binding Regulation Of Mitotic Cell Cycle, Embryonic Pancreas Development Fucose Binding Regulation Of Secondary Heart Field Cardioblast Proliferation Endomembrane System Chloride Channel Inhibitor Activity Vesicle Fusion With Golgi Apparatus Plasma Membrane Pattern Recognition Receptor Activity Perinuclear Region Of Cytoplasm Regulation Of Calcium Ion Import Negative Regulation Of Gliogenesis Regulation Of Cardioblast Proliferation Bleb Assembly Positive Regulation Of Phosphate Metabolic Process SNARE Complex Organelle Membrane Identical Protein Binding Nephron Tubule Formation Negative Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Autophosphorylation Nephron Tubule Morphogenesis Cellular Response To Epinephrine Stimulus Vitamin K Metabolic Process Kidney Morphogenesis Positive Regulation Of Kinase Activity Negative Regulation Of Calcium Ion Import Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Monocyte Chemotactic Protein-1 Production