PMP22 and MPZ

Number of citations of the paper that reports this interaction (PMID 10212299)
8

Data Source:
HPRD (in vitro, in vivo)

		PMP22	MPZ
Gene Name		peripheral myelin protein 22	myelin protein zero
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Tight Junction Integral Component Of Membrane Compact Myelin	Plasma Membrane Integral Component Of Plasma Membrane Myelin Sheath
	Molecular Function	Protein Binding	Structural Molecule Activity
	Biological Process	Synaptic Transmission Peripheral Nervous System Development Cell Death Negative Regulation Of Cell Proliferation Negative Regulation Of Neuron Projection Development Bleb Assembly Myelin Assembly	Synaptic Transmission Cell-cell Junction Maintenance
Pathways
Drugs
Diseases
GWAS		Corneal structure ( 23291589)	Visceral adipose tissue adjusted for BMI ( 22589738)
Protein-Protein Interactions		6 interactors: CANX DDX52 KLRC1 MPZ PEX19 SMIM3	3 interactors: PINX1 PMP22 PSMB3
Entrez ID		5376	4359
HPRD ID		03059	01159
Ensembl ID		ENSG00000109099	ENSG00000158887
Uniprot IDs		Q01453 Q6FH25	P25189
PDB IDs			1N2P 3OAI
Enriched GO Terms of Interacting Partners?		Chaperone-mediated Protein Folding Negative Regulation Of Lipid Binding Peroxisome Membrane Biogenesis Protein Folding Chaperone-mediated Protein Transport Protein Import Into Peroxisome Membrane Peroxisomal Membrane Transport Cell-cell Junction Maintenance Peroxisome Fission Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Cellular Component Maintenance Membrane Biogenesis Synaptic Transmission Synaptic Vesicle Endocytosis Clathrin-mediated Endocytosis Synaptic Vesicle Recycling	Negative Regulation Of Transferase Activity Bleb Assembly Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Negative Regulation Of Cell Proliferation Mitotic Cell Cycle Process RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Mitotic Cell Cycle Negative Regulation Of Catalytic Activity Mitotic Metaphase Plate Congression Telomere Maintenance Via Telomere Lengthening Myelin Assembly Metaphase Plate Congression Establishment Of Chromosome Localization Cell Cycle Process Cell Death Death Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Cell Cycle Positive Regulation Of Ligase Activity Telomere Maintenance Mitotic Sister Chromatid Segregation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Sister Chromatid Segregation Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Proliferation Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Negative Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint
Tagcloud ?		17q acrocentric anchor backcross centromeric cfa9 cryba1 distally dog galk1 gh1 giemsa hsa17 hsa17p hsa17q interbreed lie loosely mmu11 myl4 nf1 p4hb paint painting spanning syntenic thirds thra1 tk1	1p35 1q 3q 7p axonal charcot cmt cmt1b cmt2 cmt2a cmt2b cmt2d dejerine demyelinating genetically hereditary hmsn hypomyelination inherited marie missense myelin neuropathies neuropathy sardinian ser44phe sottas tooth zero
Tagcloud (Difference) ?		17q acrocentric anchor backcross centromeric cfa9 cryba1 distally dog galk1 gh1 giemsa hsa17 hsa17p hsa17q interbreed lie loosely mmu11 myl4 nf1 p4hb paint painting spanning syntenic thirds thra1 tk1	1p35 1q 3q 7p axonal charcot cmt cmt1b cmt2 cmt2a cmt2b cmt2d dejerine demyelinating genetically hereditary hmsn hypomyelination inherited marie missense myelin neuropathies neuropathy sardinian ser44phe sottas tooth zero
Tagcloud (Intersection) ?